6SB0

cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases

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Welcome
RCSB PDB Mol* Viewer 2.11.1 [12/17/2024, 1:59:56 PM]
Sequence of
     ​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​     ​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​21   ​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​     ​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​41   ​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​51   ​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​SER​61   ​THR​​ARG​​PHE​​TYR​​ASP​​GLN​​LEU​​ASN​​HIS​​HIS​71   ​ILE​​PHE​​GLU​​LEU​​VAL​​SER​​SER​​SER​​ASP​​ALA​     ​ASN​​GLU​​ARG​​LYS​​GLY​​GLY​​ILE​​LEU​​ALA​​ILE​91   ​ALA​​SER​​LEU​​ILE​​GLY​​VAL​​GLU​​GLY​​GLY​​ASN​101  ​ALA​​THR​​ARG​​ILE​​GLY​​ARG​​PHE​​ALA​​ASN​​TYR​111  ​LEU​​ARG​​ASN​​LEU​​LEU​​PRO​​SER​​ASN​​ASP​​PRO​121  ​VAL​​VAL​​MET​​GLU​​MET​​ALA​​SER​​LYS​​ALA​​ILE​131  ​GLY​​ARG​​LEU​​ALA​​MET​​ALA​​GLY​​ASP​​THR​​PHE​141  ​THR​​ALA​​GLU​​TYR​​VAL​​GLU​​PHE​​GLU​​VAL​​LYS​151  ​ARG​​ALA​​LEU​​GLU​​TRP​​LEU​​GLY​​ALA​​ASP​​ARG​     ​ASN​​GLU​​GLY​​ARG​​ARG​​HIS​​ALA​​ALA​​VAL​​LEU​171  ​VAL​​LEU​​ARG​​GLU​​LEU​​ALA​​ILE​​SER​​VAL​​PRO​181  ​THR​​PHE​​PHE​​PHE​​GLN​​GLN​​VAL​​GLN​​PRO​​PHE​191  ​PHE​​ASP​​ASN​​ILE​​PHE​​VAL​​ALA​​VAL​​TRP​​ASP​201  ​PRO​​LYS​​GLN​​ALA​​ILE​​ARG​​GLU​​GLY​​ALA​​VAL​211  ​ALA​​ALA​​LEU​​ARG​​ALA​​CYS​​LEU​​ILE​​LEU​​THR​221  ​THR​​GLN​​ARG​​GLU​​PRO​​LYS​​GLU​​MET​​GLN​​LYS​     ​PRO​​GLN​​TRP​​TYR​​ARG​​HIS​​THR​​PHE​​GLU​​GLU​241  ​ALA​​GLU​​LYS​​GLY​​PHE​​ASP​​GLU​​THR​​LEU​​ALA​     ​LYS​​GLU​​LYS​​GLY​​MET​​ASN​​ARG​​ASP​​ASP​​ARG​261  ​ILE​​HIS​​GLY​​ALA​​LEU​​LEU​​ILE​​LEU​​ASN​​GLU​271  ​LEU​​VAL​​ARG​​ILE​​SER​​SER​​MET​​GLU​​GLY​​GLU​281  ​ARG​​LEU​​ARG​​GLU​​GLU​​MET​​GLU​​GLU​​ILE​​THR​     ​GLN​​GLN​​GLN​​LEU​​VAL​​HIS​​ASP​​LYS​​TYR​​CYS​     ​LYS​​ASP​​LEU​​MET​​GLY​​PHE​​GLY​​THR​​LYS​​PRO​     ​ARG​​HIS​​ILE​​THR​​PRO​​PHE​​THR​​SER​​PHE​​GLN​     ​ALA​​VAL​​GLN​​PRO​​GLN​​GLN​​SER​​ASN​​ALA​​LEU​     ​VAL​​GLY​​LEU​​LEU​​GLY​​TYR​​SER​​SER​​HIS​​GLN​     ​GLY​​LEU​​MET​​GLY​​PHE​​GLY​​THR​​SER​​PRO​​SER​     ​PRO​​ALA​​LYS​​SER​​THR​​UNK​​UNK​​UNK​​UNK​​UNK​361  ​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​371  ​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​​UNK​     ​ARG​​ASN​​SER​​LYS​​ASN​​SER​​LEU​​ILE​​GLN​​MET​391  ​THR​​ILE​​LEU​​ASN​​LEU​​LEU​​PRO​​ARG​​LEU​​ALA​401  ​ALA​​PHE​​ARG​​PRO​​SER​​ALA​​PHE​​THR​​ASP​​THR​411  ​GLN​​TYR​​LEU​​GLN​​ASP​​THR​​MET​​ASN​​HIS​​VAL​421  ​LEU​​SER​​CYS​​VAL​​LYS​​LYS​​GLU​​LYS​​GLU​​ARG​431  ​THR​​ALA​​ALA​​PHE​​GLN​​ALA​​LEU​​GLY​​LEU​​LEU​441  ​SER​​VAL​​ALA​​VAL​​ARG​​SER​​GLU​​PHE​​LYS​​VAL​451  ​TYR​​LEU​​PRO​​ARG​​VAL​​LEU​​ASP​​ILE​​ILE​​ARG​461  ​ALA​​ALA​​LEU​​PRO​​PRO​​LYS​​ASP​​PHE​​ALA​​HIS​     ​LYS​​ARG​​GLN​​LYS​​ALA​​MET​​GLN​​VAL​​ASP​​ALA​481  ​THR​​VAL​​PHE​​THR​​CYS​​ILE​​SER​​MET​​LEU​​ALA​491  ​ARG​​ALA​​MET​​GLY​​PRO​​GLY​​ILE​​GLN​​GLN​​ASP​501  ​ILE​​LYS​​GLU​​LEU​​LEU​​GLU​​PRO​​MET​​LEU​​ALA​511  ​VAL​​GLY​​LEU​​SER​​PRO​​ALA​​LEU​​THR​​ALA​​VAL​521  ​LEU​​TYR​​ASP​​LEU​​SER​​ARG​​GLN​​ILE​​PRO​​GLN​531  ​LEU​​LYS​​LYS​​ASP​​ILE​​GLN​​ASP​​GLY​​LEU​​LEU​541  ​LYS​​MET​​LEU​​SER​​LEU​​VAL​​LEU​​MET​​HIS​​LYS​     ​PRO​​LEU​​ARG​​HIS​​PRO​​GLY​​MET​​PRO​​LYS​​GLY​     ​LEU​​ALA​​HIS​​GLN​​LEU​​ALA​​SER​​PRO​​GLY​​LEU​     ​THR​​THR​​LEU​​PRO​​GLU​​ALA​​SER​​ASP​​VAL​​GLY​581  ​SER​​ILE​​THR​​LEU​​ALA​​LEU​​ARG​​THR​​LEU​​GLY​591  ​SER​​PHE​​GLU​​PHE​​GLU​​GLY​​HIS​​SER​​LEU​​THR​601  ​GLN​​PHE​​VAL​​ARG​​HIS​​CYS​​ALA​​ASP​​HIS​​PHE​611  ​LEU​​ASN​​SER​​GLU​​HIS​​LYS​​GLU​​ILE​​ARG​​MET​621  ​GLU​​ALA​​ALA​​ARG​​THR​​CYS​​SER​​ARG​​LEU​​LEU​631  ​THR​​PRO​​SER​​ILE​​HIS​​LEU​​ILE​​SER​​GLY​​HIS​     ​ALA​​HIS​​VAL​​VAL​​SER​​GLN​​THR​​ALA​​VAL​​GLN​651  ​VAL​​VAL​​ALA​​ASP​​VAL​​LEU​​SER​​LYS​​LEU​​LEU​661  ​VAL​​VAL​​GLY​​ILE​​THR​​ASP​​PRO​​ASP​​PRO​​ASP​671  ​ILE​​ARG​​TYR​​CYS​​VAL​​LEU​​ALA​​SER​​LEU​​ASP​681  ​GLU​​ARG​​PHE​​ASP​​ALA​​HIS​​LEU​​ALA​​GLN​​ALA​691  ​GLU​​ASN​​LEU​​GLN​​ALA​​LEU​​PHE​​VAL​​ALA​​LEU​701  ​ASN​​ASP​​GLN​​VAL​​PHE​​GLU​​ILE​​ARG​​GLU​​LEU​711  ​ALA​​ILE​​CYS​​THR​​VAL​​GLY​​ARG​​LEU​​SER​​SER​721  ​MET​​ASN​​PRO​​ALA​​PHE​​VAL​​MET​​PRO​​PHE​​LEU​731  ​ARG​​LYS​​MET​​LEU​​ILE​​GLN​​ILE​​LEU​​THR​​GLU​741  ​LEU​​GLU​​HIS​​SER​​GLY​​ILE​​GLY​​ARG​​ILE​​LYS​751  ​GLU​​GLN​​SER​​ALA​​ARG​​MET​​LEU​​GLY​​HIS​​LEU​761  ​VAL​​SER​​ASN​​ALA​​PRO​​ARG​​LEU​​ILE​​ARG​​PRO​771  ​TYR​​MET​​GLU​​PRO​​ILE​​LEU​​LYS​​ALA​​LEU​​ILE​781  ​LEU​​LYS​​LEU​​LYS​​ASP​​PRO​​ASP​​PRO​​ASP​​PRO​791  ​ASN​​PRO​​GLY​​VAL​​ILE​​ASN​​ASN​​VAL​​LEU​​ALA​801  ​THR​​ILE​​GLY​​GLU​​LEU​​ALA​​GLN​​VAL​​SER​​GLY​811  ​LEU​​GLU​​MET​​ARG​​LYS​​TRP​​VAL​​ASP​​GLU​​LEU​821  ​PHE​​ILE​​ILE​​ILE​​MET​​ASP​​MET​​LEU​​GLN​​ASP​831  ​SER​​SER​​LEU​​LEU​​ALA​​LYS​​ARG​​GLN​​VAL​​ALA​841  ​LEU​​TRP​​THR​​LEU​​GLY​​GLN​​LEU​​VAL​​ALA​​SER​851  ​THR​​GLY​​TYR​​VAL​​VAL​​GLU​​PRO​​TYR​​ARG​​LYS​861  ​TYR​​PRO​​THR​​LEU​​LEU​​GLU​​VAL​​LEU​​LEU​​ASN​871  ​PHE​​LEU​​LYS​​THR​​GLU​​GLN​​ASN​​GLN​​GLY​​THR​881  ​ARG​​ARG​​GLU​​ALA​​ILE​​ARG​​VAL​​LEU​​GLY​​LEU​891  ​LEU​​GLY​​ALA​​LEU​​ASP​​PRO​​TYR​​LYS​​HIS​​LYS​901  ​VAL​​ASN​​ILE​​GLY​​MET​​ILE​​ASP​​GLN​​SER​​ARG​     ​ASP​​ALA​​SER​​ALA​​VAL​​SER​​LEU​​SER​​GLU​​SER​     ​LYS​​SER​​SER​​GLN​​ASP​​SER​​SER​​ASP​​TYR​​SER​     ​THR​​SER​​GLU​​MET​​LEU​​VAL​​ASN​​MET​​GLY​​ASN​941  ​LEU​​PRO​​LEU​​ASP​​GLU​​PHE​​TYR​​PRO​​ALA​​VAL​951  ​SER​​MET​​VAL​​ALA​​LEU​​MET​​ARG​​ILE​​PHE​​ARG​961  ​ASP​​GLN​​SER​​LEU​​SER​​HIS​​HIS​​HIS​​THR​​MET​971  ​VAL​​VAL​​GLN​​ALA​​ILE​​THR​​PHE​​ILE​​PHE​​LYS​981  ​SER​​LEU​​GLY​​LEU​​LYS​​CYS​​VAL​​GLN​​PHE​​LEU​991  ​PRO​​GLN​​VAL​​MET​​PRO​​THR​​PHE​​LEU​​ASN​​VAL​1001 ​ILE​​ARG​​VAL​​CYS​​ASP​​GLY​​ALA​​ILE​​ARG​​GLU​1011 ​PHE​​LEU​​PHE​​GLN​​GLN​​LEU​​GLY​​MET​​LEU​​VAL​1021 ​SER​​PHE​​VAL​​LYS​​SER​​HIS​​ILE​​ARG​​PRO​​TYR​1031 ​MET​​ASP​​GLU​​ILE​​VAL​​THR​​LEU​​MET​​ARG​​GLU​1041 ​PHE​​TRP​​VAL​​MET​​ASN​​THR​​SER​​ILE​​GLN​​SER​1051 ​THR​​ILE​​ILE​​LEU​​LEU​​ILE​​GLU​​GLN​​ILE​​VAL​1061 ​VAL​​ALA​​LEU​​GLY​​GLY​​GLU​​PHE​​LYS​​LEU​​TYR​1071 ​LEU​​PRO​​GLN​​LEU​​ILE​​PRO​​HIS​​MET​​LEU​​ARG​1081 ​VAL​​PHE​​MET​​HIS​​ASP​​ASN​​SER​​PRO​​GLY​​ARG​1091 ​ILE​​VAL​​SER​​ILE​​LYS​​LEU​​LEU​​ALA​​ALA​​ILE​1101 ​GLN​​LEU​​PHE​​GLY​​ALA​​ASN​​LEU​​ASP​​ASP​​TYR​1111 ​LEU​​HIS​​LEU​​LEU​​LEU​​PRO​​PRO​​ILE​​VAL​​LYS​1121 ​LEU​​PHE​​ASP​​ALA​​PRO​​GLU​​ALA​​PRO​​LEU​​PRO​1131 ​SER​​ARG​​LYS​​ALA​​ALA​​LEU​​GLU​​THR​​VAL​​ASP​1141 ​ARG​​LEU​​THR​​GLU​​SER​​LEU​​ASP​​PHE​​THR​​ASP​1151 ​TYR​​ALA​​SER​​ARG​​ILE​​ILE​​HIS​​PRO​​ILE​​VAL​1161 ​ARG​​THR​​LEU​​ASP​​GLN​​SER​​PRO​​GLU​​LEU​​ARG​1171 ​SER​​THR​​ALA​​MET​​ASP​​THR​​LEU​​SER​​SER​​LEU​1181 ​VAL​​PHE​​GLN​​LEU​​GLY​​LYS​​LYS​​TYR​​GLN​​ILE​1191 ​PHE​​ILE​​PRO​​MET​​VAL​​ASN​​LYS​​VAL​​LEU​​VAL​1201 ​ARG​​HIS​​ARG​​ILE​​ASN​​HIS​​GLN​​ARG​​TYR​​ASP​1211 ​VAL​​LEU​​ILE​​CYS​​ARG​​ILE​​VAL​​LYS​​GLY​​TYR​1221 ​THR​​LEU​​ALA​​ASP​​GLU​​GLU​​GLU​​ASP​​PRO​​LEU​     ​ILE​​TYR​​GLN​​HIS​​ARG​​MET​​LEU​​ARG​​SER​​GLY​     ​GLN​​GLY​​ASP​​ALA​​LEU​​ALA​​SER​​GLY​​PRO​​VAL​     ​GLU​​THR​​GLY​​PRO​​MET​​LYS​​LYS​​LEU​​HIS​​VAL​1261 ​SER​​THR​​ILE​​ASN​​LEU​​GLN​​LYS​​ALA​​TRP​​GLY​1271 ​ALA​​ALA​​ARG​​ARG​​VAL​​SER​​LYS​​ASP​​ASP​​TRP​1281 ​LEU​​GLU​​TRP​​LEU​​ARG​​ARG​​LEU​​SER​​LEU​​GLU​1291 ​LEU​​LEU​​LYS​​ASP​​SER​​SER​​SER​​PRO​​SER​​LEU​1301 ​ARG​​SER​​CYS​​TRP​​ALA​​LEU​​ALA​​GLN​​ALA​​TYR​1311 ​ASN​​PRO​​MET​​ALA​​ARG​​ASP​​LEU​​PHE​​ASN​​ALA​1321 ​ALA​​PHE​​VAL​​SER​​CYS​​TRP​​SER​​GLU​​LEU​​ASN​1331 ​GLU​​ASP​​GLN​​GLN​​ASP​​GLU​​LEU​​ILE​​ARG​​SER​1341 ​ILE​​GLU​​LEU​​ALA​​LEU​​THR​​SER​​GLN​​ASP​​ILE​1351 ​ALA​​GLU​​VAL​​THR​​GLN​​THR​​LEU​​LEU​​ASN​​LEU​1361 ​ALA​​GLU​​PHE​​MET​​GLU​​HIS​​SER​​ASP​​LYS​​GLY​1371 ​PRO​​LEU​​PRO​​LEU​​ARG​​ASP​​ASP​​ASN​​GLY​​ILE​1381 ​VAL​​LEU​​LEU​​GLY​​GLU​​ARG​​ALA​​ALA​​LYS​​CYS​1391 ​ARG​​ALA​​TYR​​ALA​​LYS​​ALA​​LEU​​HIS​​TYR​​LYS​1401 ​GLU​​LEU​​GLU​​PHE​​GLN​​LYS​​GLY​​PRO​​THR​​PRO​1411 ​ALA​​ILE​​LEU​​GLU​​SER​​LEU​​ILE​​SER​​ILE​​ASN​1421 ​ASN​​LYS​​LEU​​GLN​​GLN​​PRO​​GLU​​ALA​​ALA​​ALA​1431 ​GLY​​VAL​​LEU​​GLU​​TYR​​ALA​​MET​​LYS​​HIS​​PHE​1441 ​GLY​​GLU​​LEU​​GLU​​ILE​​GLN​​ALA​​THR​​TRP​​TYR​1451 ​GLU​​LYS​​LEU​​HIS​​GLU​​TRP​​GLU​​ASP​​ALA​​LEU​1461 ​VAL​​ALA​​TYR​​ASP​​LYS​​LYS​​MET​​ASP​​THR​​ASN​1471 ​LYS​​ASP​​ASP​​PRO​​GLU​​LEU​​MET​​LEU​​GLY​​ARG​1481 ​MET​​ARG​​CYS​​LEU​​GLU​​ALA​​LEU​​GLY​​GLU​​TRP​1491 ​GLY​​GLN​​LEU​​HIS​​GLN​​GLN​​CYS​​CYS​​GLU​​LYS​1501 ​TRP​​THR​​LEU​​VAL​​ASN​​ASP​​GLU​​THR​​GLN​​ALA​1511 ​LYS​​MET​​ALA​​ARG​​MET​​ALA​​ALA​​ALA​​ALA​​ALA​1521 ​TRP​​GLY​​LEU​​GLY​​GLN​​TRP​​ASP​​SER​​MET​​GLU​1531 ​GLU​​TYR​​THR​​CYS​​MET​​ILE​​PRO​​ARG​​ASP​​THR​1541 ​HIS​​ASP​​GLY​​ALA​​PHE​​TYR​​ARG​​ALA​​VAL​​LEU​1551 ​ALA​​LEU​​HIS​​GLN​​ASP​​LEU​​PHE​​SER​​LEU​​ALA​1561 ​GLN​​GLN​​CYS​​ILE​​ASP​​LYS​​ALA​​ARG​​ASP​​LEU​1571 ​LEU​​ASP​​ALA​​GLU​​LEU​​THR​​ALA​​MET​​ALA​​GLY​1581 ​GLU​​SER​​TYR​​SER​​ARG​​ALA​​TYR​​GLY​​ALA​​MET​1591 ​VAL​​SER​​CYS​​HIS​​MET​​LEU​​SER​​GLU​​LEU​​GLU​1601 ​GLU​​VAL​​ILE​​GLN​​TYR​​LYS​​LEU​​VAL​​PRO​​GLU​1611 ​ARG​​ARG​​GLU​​ILE​​ILE​​ARG​​GLN​​ILE​​TRP​​TRP​1621 ​GLU​​ARG​​LEU​​GLN​​GLY​​CYS​​GLN​​ARG​​ILE​​VAL​1631 ​GLU​​ASP​​TRP​​GLN​​LYS​​ILE​​LEU​​MET​​VAL​​ARG​1641 ​SER​​LEU​​VAL​​VAL​​SER​​PRO​​HIS​​GLU​​ASP​​MET​1651 ​ARG​​THR​​TRP​​LEU​​LYS​​TYR​​ALA​​SER​​LEU​​CYS​1661 ​GLY​​LYS​​SER​​GLY​​ARG​​LEU​​ALA​​LEU​​ALA​​HIS​1671 ​LYS​​THR​​LEU​​VAL​​LEU​​LEU​​LEU​​GLY​​VAL​​ASP​1681 ​PRO​​SER​​ARG​​GLN​​LEU​​ASP​​HIS​​PRO​​LEU​​PRO​1691 ​THR​​VAL​​HIS​​PRO​​GLN​​VAL​​THR​​TYR​​ALA​​TYR​1701 ​MET​​LYS​​ASN​​MET​​TRP​​LYS​​SER​​ALA​​ARG​​LYS​1711 ​ILE​​ASP​​ALA​​PHE​​GLN​​HIS​​MET​​GLN​​HIS​​PHE​1721 ​VAL​​GLN​​THR​​MET​​GLN​​GLN​​GLN​​ALA​​GLN​​HIS​1731 ​ALA​​ILE​​ALA​​THR​​GLU​​ASP​​GLN​​GLN​​HIS​​LYS​1741 ​GLN​​GLU​​LEU​​HIS​​LYS​​LEU​​MET​​ALA​​ARG​​CYS​1751 ​PHE​​LEU​​LYS​​LEU​​GLY​​GLU​​TRP​​GLN​​LEU​​ASN​1761 ​LEU​​GLN​​GLY​​ILE​​ASN​​GLU​​SER​​THR​​ILE​​PRO​1771 ​LYS​​VAL​​LEU​​GLN​​TYR​​TYR​​SER​​ALA​​ALA​​THR​1781 ​GLU​​HIS​​ASP​​ARG​​SER​​TRP​​TYR​​LYS​​ALA​​TRP​1791 ​HIS​​ALA​​TRP​​ALA​​VAL​​MET​​ASN​​PHE​​GLU​​ALA​1801 ​VAL​​LEU​​HIS​​TYR​​LYS​​HIS​​GLN​​ASN​​GLN​​ALA​1811 ​ARG​​ASP​​GLU​​LYS​​LYS​​LYS​​LEU​​ARG​​HIS​​ALA​     ​SER​​GLY​​ALA​​ASN​​ILE​​THR​​ASN​​ALA​​THR​​THR​     ​ALA​​ALA​​THR​​THR​​ALA​​ALA​​THR​​ALA​​THR​​THR​     ​THR​​ALA​​SER​​THR​​GLU​​GLY​​SER​​ASN​​SER​​GLU​     ​SER​​GLU​​ALA​​GLU​​SER​​THR​​GLU​​ASN​​SER​​PRO​     ​THR​​PRO​​SER​​PRO​​LEU​​GLN​​LYS​​LYS​​VAL​​THR​1871 ​GLU​​ASP​​LEU​​SER​​LYS​​THR​​LEU​​LEU​​MET​​TYR​1881 ​THR​​VAL​​PRO​​ALA​​VAL​​GLN​​GLY​​PHE​​PHE​​ARG​1891 ​SER​​ILE​​SER​​LEU​​SER​​ARG​​GLY​​ASN​​ASN​​LEU​1901 ​GLN​​ASP​​THR​​LEU​​ARG​​VAL​​LEU​​THR​​LEU​​TRP​1911 ​PHE​​ASP​​TYR​​GLY​​HIS​​TRP​​PRO​​ASP​​VAL​​ASN​1921 ​GLU​​ALA​​LEU​​VAL​​GLU​​GLY​​VAL​​LYS​​ALA​​ILE​1931 ​GLN​​ILE​​ASP​​THR​​TRP​​LEU​​GLN​​VAL​​ILE​​PRO​1941 ​GLN​​LEU​​ILE​​ALA​​ARG​​ILE​​ASP​​THR​​PRO​​ARG​1951 ​PRO​​LEU​​VAL​​GLY​​ARG​​LEU​​ILE​​HIS​​GLN​​LEU​1961 ​LEU​​THR​​ASP​​ILE​​GLY​​ARG​​TYR​​HIS​​PRO​​GLN​1971 ​ALA​​LEU​​ILE​​TYR​​PRO​​LEU​​THR​​VAL​​ALA​​SER​1981 ​LYS​​SER​​THR​​THR​​THR​​ALA​​ARG​​HIS​​ASN​​ALA​1991 ​ALA​​ASN​​LYS​​ILE​​LEU​​LYS​​ASN​​MET​​CYS​​GLU​2001 ​HIS​​SER​​ASN​​THR​​LEU​​VAL​​GLN​​GLN​​ALA​​MET​2011 ​MET​​VAL​​SER​​GLU​​GLU​​LEU​​ILE​​ARG​​VAL​​ALA​2021 ​ILE​​LEU​​TRP​​HIS​​GLU​​MET​​TRP​​HIS​​GLU​​GLY​2031 ​LEU​​GLU​​GLU​​ALA​​SER​​ARG​​LEU​​TYR​​PHE​​GLY​2041 ​GLU​​ARG​​ASN​​VAL​​LYS​​GLY​​MET​​PHE​​GLU​​VAL​2051 ​LEU​​GLU​​PRO​​LEU​​HIS​​ALA​​MET​​MET​​GLU​​ARG​2061 ​GLY​​PRO​​GLN​​THR​​LEU​​LYS​​GLU​​THR​​SER​​PHE​2071 ​ASN​​GLN​​ALA​​TYR​​GLY​​ARG​​ASP​​LEU​​MET​​GLU​2081 ​ALA​​GLN​​GLU​​TRP​​CYS​​ARG​​LYS​​TYR​​MET​​LYS​2091 ​SER​​GLY​​ASN​​VAL​​LYS​​ASP​​LEU​​THR​​GLN​​ALA​2101 ​TRP​​ASP​​LEU​​TYR​​TYR​​HIS​​VAL​​PHE​​ARG​​ARG​2111 ​ILE​​SER​​LYS​​GLN​​LEU​​PRO​​GLN​​LEU​​THR​​SER​2121 ​LEU​​GLU​​LEU​​GLN​​TYR​​VAL​​SER​​PRO​​LYS​​LEU​2131 ​LEU​​MET​​CYS​​ARG​​ASP​​LEU​​GLU​​LEU​​ALA​​VAL​2141 ​PRO​​GLY​​THR​​TYR​​ASP​​PRO​​ASN​​GLN​​PRO​​ILE​2151 ​ILE​​ARG​​ILE​​GLN​​SER​​ILE​​ALA​​PRO​​SER​​LEU​2161 ​GLN​​VAL​​ILE​​THR​​SER​​LYS​​GLN​​ARG​​PRO​​ARG​2171 ​LYS​​LEU​​THR​​LEU​​MET​​GLY​​SER​​ASN​​GLY​​HIS​2181 ​GLU​​PHE​​VAL​​PHE​​LEU​​LEU​​LYS​​GLY​​HIS​​GLU​2191 ​ASP​​LEU​​ARG​​GLN​​ASP​​GLU​​ARG​​VAL​​MET​​GLN​2201 ​LEU​​PHE​​GLY​​LEU​​VAL​​ASN​​THR​​LEU​​LEU​​ALA​2211 ​ASN​​ASP​​PRO​​THR​​SER​​LEU​​ARG​​LYS​​ASN​​LEU​2221 ​SER​​ILE​​GLN​​ARG​​TYR​​ALA​​VAL​​ILE​​PRO​​LEU​2231 ​SER​​THR​​ASN​​SER​​GLY​​LEU​​ILE​​GLY​​TRP​​VAL​2241 ​PRO​​HIS​​CYS​​ASP​​THR​​LEU​​HIS​​ALA​​LEU​​ILE​2251 ​ARG​​ASP​​TYR​​ARG​​GLU​​LYS​​LYS​​LYS​​ILE​​LEU​2261 ​LEU​​ASN​​ILE​​GLU​​HIS​​ARG​​ILE​​MET​​LEU​​ARG​2271 ​MET​​ALA​​PRO​​ASP​​TYR​​ASP​​HIS​​LEU​​THR​​LEU​2281 ​MET​​GLN​​LYS​​VAL​​GLU​​VAL​​PHE​​GLU​​HIS​​ALA​2291 ​VAL​​ASN​​ASN​​THR​​ALA​​GLY​​ASP​​ASP​​LEU​​ALA​2301 ​LYS​​LEU​​LEU​​TRP​​LEU​​LYS​​SER​​PRO​​SER​​SER​2311 ​GLU​​VAL​​TRP​​PHE​​ASP​​ARG​​ARG​​THR​​ASN​​TYR​2321 ​THR​​ARG​​SER​​LEU​​ALA​​VAL​​MET​​SER​​MET​​VAL​2331 ​GLY​​TYR​​ILE​​LEU​​GLY​​LEU​​GLY​​ASP​​ARG​​HIS​2341 ​PRO​​SER​​ASN​​LEU​​MET​​LEU​​ASP​​ARG​​LEU​​SER​2351 ​GLY​​LYS​​ILE​​LEU​​HIS​​ILE​​ASP​​PHE​​GLY​​ASP​2361 ​CYS​​PHE​​GLU​​VAL​​ALA​​MET​​THR​​ARG​​GLU​​LYS​2371 ​PHE​​PRO​​GLU​​LYS​​ILE​​PRO​​PHE​​ARG​​LEU​​THR​2381 ​ARG​​MET​​LEU​​THR​​ASN​​ALA​​MET​​GLU​​VAL​​THR​2391 ​GLY​​LEU​​ASP​​GLY​​ASN​​TYR​​ARG​​ILE​​THR​​CYS​2401 ​HIS​​THR​​VAL​​MET​​GLU​​VAL​​LEU​​ARG​​GLU​​HIS​2411 ​LYS​​ASP​​SER​​VAL​​MET​​ALA​​VAL​​LEU​​GLU​​ALA​2421 ​PHE​​VAL​​TYR​​ASP​​PRO​​LEU​​LEU​​ASN​​TRP​​ARG​2431 ​LEU​​MET​​ASP​​THR​​ASN​​THR​​LYS​​GLY​​ASN​​LYS​     ​ARG​​SER​​ARG​​THR​​ARG​​THR​​ASP​​SER​​TYR​​SER​     ​ALA​​GLY​​GLN​​SER​​VAL​​GLU​​ILE​​LEU​​ASP​​GLY​     ​VAL​​GLU​​LEU​​GLY​​GLU​​PRO​​ALA​​HIS​​LYS​​LYS​     ​THR​​GLY​​THR​​THR​​VAL​​PRO​​GLU​​SER​​ILE​​HIS​     ​SER​​PHE​​ILE​​GLY​​ASP​​GLY​​LEU​​VAL​​LYS​​PRO​     ​GLU​​ALA​​LEU​​ASN​​LYS​​LYS​​ALA​​ILE​​GLN​​ILE​2501 ​ILE​​ASN​​ARG​​VAL​​ARG​​ASP​​LYS​​LEU​​THR​​GLY​2511 ​ARG​​ASP​​PHE​​SER​​HIS​​ASP​​ASP​​THR​​LEU​​ASP​2521 ​VAL​​PRO​​THR​​GLN​​VAL​​GLU​​LEU​​LEU​​ILE​​LYS​2531 ​GLN​​ALA​​THR​​SER​​HIS​​GLU​​ASN​​LEU​​CYS​​GLN​2541 ​CYS​​TYR​​ILE​​GLY​​TRP​​CYS​​PRO​​PHE​​TRP​
Type
Asm Id
Dynamic Bonds

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