6SB0
cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases
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RCSB PDB Mol* Viewer 2.11.1 [12/17/2024, 1:59:56 PM]
Sequence of
UNKUNKUNKUNKUNKUNKUNKUNKUNKUNK UNKUNKUNKUNKUNKUNKUNKUNKUNKUNK21 UNKUNKUNKUNKUNKUNKUNKUNKUNKUNK UNKUNKUNKUNKUNKUNKUNKUNKUNKUNK41 UNKUNKUNKUNKUNKUNKUNKUNKUNKUNK51 UNKUNKUNKUNKUNKUNKUNKUNKUNKSER61 THRARGPHETYRASPGLNLEUASNHISHIS71 ILEPHEGLULEUVALSERSERSERASPALA ASNGLUARGLYSGLYGLYILELEUALAILE91 ALASERLEUILEGLYVALGLUGLYGLYASN101 ALATHRARGILEGLYARGPHEALAASNTYR111 LEUARGASNLEULEUPROSERASNASPPRO121 VALVALMETGLUMETALASERLYSALAILE131 GLYARGLEUALAMETALAGLYASPTHRPHE141 THRALAGLUTYRVALGLUPHEGLUVALLYS151 ARGALALEUGLUTRPLEUGLYALAASPARG ASNGLUGLYARGARGHISALAALAVALLEU171 VALLEUARGGLULEUALAILESERVALPRO181 THRPHEPHEPHEGLNGLNVALGLNPROPHE191 PHEASPASNILEPHEVALALAVALTRPASP201 PROLYSGLNALAILEARGGLUGLYALAVAL211 ALAALALEUARGALACYSLEUILELEUTHR221 THRGLNARGGLUPROLYSGLUMETGLNLYS PROGLNTRPTYRARGHISTHRPHEGLUGLU241 ALAGLULYSGLYPHEASPGLUTHRLEUALA LYSGLULYSGLYMETASNARGASPASPARG261 ILEHISGLYALALEULEUILELEUASNGLU271 LEUVALARGILESERSERMETGLUGLYGLU281 ARGLEUARGGLUGLUMETGLUGLUILETHR GLNGLNGLNLEUVALHISASPLYSTYRCYS LYSASPLEUMETGLYPHEGLYTHRLYSPRO ARGHISILETHRPROPHETHRSERPHEGLN ALAVALGLNPROGLNGLNSERASNALALEU VALGLYLEULEUGLYTYRSERSERHISGLN GLYLEUMETGLYPHEGLYTHRSERPROSER PROALALYSSERTHRUNKUNKUNKUNKUNK361 UNKUNKUNKUNKUNKUNKUNKUNKUNKUNK371 UNKUNKUNKUNKUNKUNKUNKUNKUNKUNK ARGASNSERLYSASNSERLEUILEGLNMET391 THRILELEUASNLEULEUPROARGLEUALA401 ALAPHEARGPROSERALAPHETHRASPTHR411 GLNTYRLEUGLNASPTHRMETASNHISVAL421 LEUSERCYSVALLYSLYSGLULYSGLUARG431 THRALAALAPHEGLNALALEUGLYLEULEU441 SERVALALAVALARGSERGLUPHELYSVAL451 TYRLEUPROARGVALLEUASPILEILEARG461 ALAALALEUPROPROLYSASPPHEALAHIS LYSARGGLNLYSALAMETGLNVALASPALA481 THRVALPHETHRCYSILESERMETLEUALA491 ARGALAMETGLYPROGLYILEGLNGLNASP501 ILELYSGLULEULEUGLUPROMETLEUALA511 VALGLYLEUSERPROALALEUTHRALAVAL521 LEUTYRASPLEUSERARGGLNILEPROGLN531 LEULYSLYSASPILEGLNASPGLYLEULEU541 LYSMETLEUSERLEUVALLEUMETHISLYS PROLEUARGHISPROGLYMETPROLYSGLY LEUALAHISGLNLEUALASERPROGLYLEU THRTHRLEUPROGLUALASERASPVALGLY581 SERILETHRLEUALALEUARGTHRLEUGLY591 SERPHEGLUPHEGLUGLYHISSERLEUTHR601 GLNPHEVALARGHISCYSALAASPHISPHE611 LEUASNSERGLUHISLYSGLUILEARGMET621 GLUALAALAARGTHRCYSSERARGLEULEU631 THRPROSERILEHISLEUILESERGLYHIS ALAHISVALVALSERGLNTHRALAVALGLN651 VALVALALAASPVALLEUSERLYSLEULEU661 VALVALGLYILETHRASPPROASPPROASP671 ILEARGTYRCYSVALLEUALASERLEUASP681 GLUARGPHEASPALAHISLEUALAGLNALA691 GLUASNLEUGLNALALEUPHEVALALALEU701 ASNASPGLNVALPHEGLUILEARGGLULEU711 ALAILECYSTHRVALGLYARGLEUSERSER721 METASNPROALAPHEVALMETPROPHELEU731 ARGLYSMETLEUILEGLNILELEUTHRGLU741 LEUGLUHISSERGLYILEGLYARGILELYS751 GLUGLNSERALAARGMETLEUGLYHISLEU761 VALSERASNALAPROARGLEUILEARGPRO771 TYRMETGLUPROILELEULYSALALEUILE781 LEULYSLEULYSASPPROASPPROASPPRO791 ASNPROGLYVALILEASNASNVALLEUALA801 THRILEGLYGLULEUALAGLNVALSERGLY811 LEUGLUMETARGLYSTRPVALASPGLULEU821 PHEILEILEILEMETASPMETLEUGLNASP831 SERSERLEULEUALALYSARGGLNVALALA841 LEUTRPTHRLEUGLYGLNLEUVALALASER851 THRGLYTYRVALVALGLUPROTYRARGLYS861 TYRPROTHRLEULEUGLUVALLEULEUASN871 PHELEULYSTHRGLUGLNASNGLNGLYTHR881 ARGARGGLUALAILEARGVALLEUGLYLEU891 LEUGLYALALEUASPPROTYRLYSHISLYS901 VALASNILEGLYMETILEASPGLNSERARG ASPALASERALAVALSERLEUSERGLUSER LYSSERSERGLNASPSERSERASPTYRSER THRSERGLUMETLEUVALASNMETGLYASN941 LEUPROLEUASPGLUPHETYRPROALAVAL951 SERMETVALALALEUMETARGILEPHEARG961 ASPGLNSERLEUSERHISHISHISTHRMET971 VALVALGLNALAILETHRPHEILEPHELYS981 SERLEUGLYLEULYSCYSVALGLNPHELEU991 PROGLNVALMETPROTHRPHELEUASNVAL1001 ILEARGVALCYSASPGLYALAILEARGGLU1011 PHELEUPHEGLNGLNLEUGLYMETLEUVAL1021 SERPHEVALLYSSERHISILEARGPROTYR1031 METASPGLUILEVALTHRLEUMETARGGLU1041 PHETRPVALMETASNTHRSERILEGLNSER1051 THRILEILELEULEUILEGLUGLNILEVAL1061 VALALALEUGLYGLYGLUPHELYSLEUTYR1071 LEUPROGLNLEUILEPROHISMETLEUARG1081 VALPHEMETHISASPASNSERPROGLYARG1091 ILEVALSERILELYSLEULEUALAALAILE1101 GLNLEUPHEGLYALAASNLEUASPASPTYR1111 LEUHISLEULEULEUPROPROILEVALLYS1121 LEUPHEASPALAPROGLUALAPROLEUPRO1131 SERARGLYSALAALALEUGLUTHRVALASP1141 ARGLEUTHRGLUSERLEUASPPHETHRASP1151 TYRALASERARGILEILEHISPROILEVAL1161 ARGTHRLEUASPGLNSERPROGLULEUARG1171 SERTHRALAMETASPTHRLEUSERSERLEU1181 VALPHEGLNLEUGLYLYSLYSTYRGLNILE1191 PHEILEPROMETVALASNLYSVALLEUVAL1201 ARGHISARGILEASNHISGLNARGTYRASP1211 VALLEUILECYSARGILEVALLYSGLYTYR1221 THRLEUALAASPGLUGLUGLUASPPROLEU ILETYRGLNHISARGMETLEUARGSERGLY GLNGLYASPALALEUALASERGLYPROVAL GLUTHRGLYPROMETLYSLYSLEUHISVAL1261 SERTHRILEASNLEUGLNLYSALATRPGLY1271 ALAALAARGARGVALSERLYSASPASPTRP1281 LEUGLUTRPLEUARGARGLEUSERLEUGLU1291 LEULEULYSASPSERSERSERPROSERLEU1301 ARGSERCYSTRPALALEUALAGLNALATYR1311 ASNPROMETALAARGASPLEUPHEASNALA1321 ALAPHEVALSERCYSTRPSERGLULEUASN1331 GLUASPGLNGLNASPGLULEUILEARGSER1341 ILEGLULEUALALEUTHRSERGLNASPILE1351 ALAGLUVALTHRGLNTHRLEULEUASNLEU1361 ALAGLUPHEMETGLUHISSERASPLYSGLY1371 PROLEUPROLEUARGASPASPASNGLYILE1381 VALLEULEUGLYGLUARGALAALALYSCYS1391 ARGALATYRALALYSALALEUHISTYRLYS1401 GLULEUGLUPHEGLNLYSGLYPROTHRPRO1411 ALAILELEUGLUSERLEUILESERILEASN1421 ASNLYSLEUGLNGLNPROGLUALAALAALA1431 GLYVALLEUGLUTYRALAMETLYSHISPHE1441 GLYGLULEUGLUILEGLNALATHRTRPTYR1451 GLULYSLEUHISGLUTRPGLUASPALALEU1461 VALALATYRASPLYSLYSMETASPTHRASN1471 LYSASPASPPROGLULEUMETLEUGLYARG1481 METARGCYSLEUGLUALALEUGLYGLUTRP1491 GLYGLNLEUHISGLNGLNCYSCYSGLULYS1501 TRPTHRLEUVALASNASPGLUTHRGLNALA1511 LYSMETALAARGMETALAALAALAALAALA1521 TRPGLYLEUGLYGLNTRPASPSERMETGLU1531 GLUTYRTHRCYSMETILEPROARGASPTHR1541 HISASPGLYALAPHETYRARGALAVALLEU1551 ALALEUHISGLNASPLEUPHESERLEUALA1561 GLNGLNCYSILEASPLYSALAARGASPLEU1571 LEUASPALAGLULEUTHRALAMETALAGLY1581 GLUSERTYRSERARGALATYRGLYALAMET1591 VALSERCYSHISMETLEUSERGLULEUGLU1601 GLUVALILEGLNTYRLYSLEUVALPROGLU1611 ARGARGGLUILEILEARGGLNILETRPTRP1621 GLUARGLEUGLNGLYCYSGLNARGILEVAL1631 GLUASPTRPGLNLYSILELEUMETVALARG1641 SERLEUVALVALSERPROHISGLUASPMET1651 ARGTHRTRPLEULYSTYRALASERLEUCYS1661 GLYLYSSERGLYARGLEUALALEUALAHIS1671 LYSTHRLEUVALLEULEULEUGLYVALASP1681 PROSERARGGLNLEUASPHISPROLEUPRO1691 THRVALHISPROGLNVALTHRTYRALATYR1701 METLYSASNMETTRPLYSSERALAARGLYS1711 ILEASPALAPHEGLNHISMETGLNHISPHE1721 VALGLNTHRMETGLNGLNGLNALAGLNHIS1731 ALAILEALATHRGLUASPGLNGLNHISLYS1741 GLNGLULEUHISLYSLEUMETALAARGCYS1751 PHELEULYSLEUGLYGLUTRPGLNLEUASN1761 LEUGLNGLYILEASNGLUSERTHRILEPRO1771 LYSVALLEUGLNTYRTYRSERALAALATHR1781 GLUHISASPARGSERTRPTYRLYSALATRP1791 HISALATRPALAVALMETASNPHEGLUALA1801 VALLEUHISTYRLYSHISGLNASNGLNALA1811 ARGASPGLULYSLYSLYSLEUARGHISALA SERGLYALAASNILETHRASNALATHRTHR ALAALATHRTHRALAALATHRALATHRTHR THRALASERTHRGLUGLYSERASNSERGLU SERGLUALAGLUSERTHRGLUASNSERPRO THRPROSERPROLEUGLNLYSLYSVALTHR1871 GLUASPLEUSERLYSTHRLEULEUMETTYR1881 THRVALPROALAVALGLNGLYPHEPHEARG1891 SERILESERLEUSERARGGLYASNASNLEU1901 GLNASPTHRLEUARGVALLEUTHRLEUTRP1911 PHEASPTYRGLYHISTRPPROASPVALASN1921 GLUALALEUVALGLUGLYVALLYSALAILE1931 GLNILEASPTHRTRPLEUGLNVALILEPRO1941 GLNLEUILEALAARGILEASPTHRPROARG1951 PROLEUVALGLYARGLEUILEHISGLNLEU1961 LEUTHRASPILEGLYARGTYRHISPROGLN1971 ALALEUILETYRPROLEUTHRVALALASER1981 LYSSERTHRTHRTHRALAARGHISASNALA1991 ALAASNLYSILELEULYSASNMETCYSGLU2001 HISSERASNTHRLEUVALGLNGLNALAMET2011 METVALSERGLUGLULEUILEARGVALALA2021 ILELEUTRPHISGLUMETTRPHISGLUGLY2031 LEUGLUGLUALASERARGLEUTYRPHEGLY2041 GLUARGASNVALLYSGLYMETPHEGLUVAL2051 LEUGLUPROLEUHISALAMETMETGLUARG2061 GLYPROGLNTHRLEULYSGLUTHRSERPHE2071 ASNGLNALATYRGLYARGASPLEUMETGLU2081 ALAGLNGLUTRPCYSARGLYSTYRMETLYS2091 SERGLYASNVALLYSASPLEUTHRGLNALA2101 TRPASPLEUTYRTYRHISVALPHEARGARG2111 ILESERLYSGLNLEUPROGLNLEUTHRSER2121 LEUGLULEUGLNTYRVALSERPROLYSLEU2131 LEUMETCYSARGASPLEUGLULEUALAVAL2141 PROGLYTHRTYRASPPROASNGLNPROILE2151 ILEARGILEGLNSERILEALAPROSERLEU2161 GLNVALILETHRSERLYSGLNARGPROARG2171 LYSLEUTHRLEUMETGLYSERASNGLYHIS2181 GLUPHEVALPHELEULEULYSGLYHISGLU2191 ASPLEUARGGLNASPGLUARGVALMETGLN2201 LEUPHEGLYLEUVALASNTHRLEULEUALA2211 ASNASPPROTHRSERLEUARGLYSASNLEU2221 SERILEGLNARGTYRALAVALILEPROLEU2231 SERTHRASNSERGLYLEUILEGLYTRPVAL2241 PROHISCYSASPTHRLEUHISALALEUILE2251 ARGASPTYRARGGLULYSLYSLYSILELEU2261 LEUASNILEGLUHISARGILEMETLEUARG2271 METALAPROASPTYRASPHISLEUTHRLEU2281 METGLNLYSVALGLUVALPHEGLUHISALA2291 VALASNASNTHRALAGLYASPASPLEUALA2301 LYSLEULEUTRPLEULYSSERPROSERSER2311 GLUVALTRPPHEASPARGARGTHRASNTYR2321 THRARGSERLEUALAVALMETSERMETVAL2331 GLYTYRILELEUGLYLEUGLYASPARGHIS2341 PROSERASNLEUMETLEUASPARGLEUSER2351 GLYLYSILELEUHISILEASPPHEGLYASP2361 CYSPHEGLUVALALAMETTHRARGGLULYS2371 PHEPROGLULYSILEPROPHEARGLEUTHR2381 ARGMETLEUTHRASNALAMETGLUVALTHR2391 GLYLEUASPGLYASNTYRARGILETHRCYS2401 HISTHRVALMETGLUVALLEUARGGLUHIS2411 LYSASPSERVALMETALAVALLEUGLUALA2421 PHEVALTYRASPPROLEULEUASNTRPARG2431 LEUMETASPTHRASNTHRLYSGLYASNLYS ARGSERARGTHRARGTHRASPSERTYRSER ALAGLYGLNSERVALGLUILELEUASPGLY VALGLULEUGLYGLUPROALAHISLYSLYS THRGLYTHRTHRVALPROGLUSERILEHIS SERPHEILEGLYASPGLYLEUVALLYSPRO GLUALALEUASNLYSLYSALAILEGLNILE2501 ILEASNARGVALARGASPLYSLEUTHRGLY2511 ARGASPPHESERHISASPASPTHRLEUASP2521 VALPROTHRGLNVALGLULEULEUILELYS2531 GLNALATHRSERHISGLUASNLEUCYSGLN2541 CYSTYRILEGLYTRPCYSPROPHETRP
Type
Asm Id
Dynamic Bonds
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