Annotations: 1AEI

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
F	d1aeif_	All alpha proteins	Annexin	Annexin	Annexin	Annexin XII	(Hydra vulgaris ) [TaxId: 6087 ],	SCOPe (2.08)
E	d1aeie_	All alpha proteins	Annexin	Annexin	Annexin	Annexin XII	(Hydra vulgaris ) [TaxId: 6087 ],	SCOPe (2.08)
D	d1aeid_	All alpha proteins	Annexin	Annexin	Annexin	Annexin XII	(Hydra vulgaris ) [TaxId: 6087 ],	SCOPe (2.08)
C	d1aeic_	All alpha proteins	Annexin	Annexin	Annexin	Annexin XII	(Hydra vulgaris ) [TaxId: 6087 ],	SCOPe (2.08)
B	d1aeib_	All alpha proteins	Annexin	Annexin	Annexin	Annexin XII	(Hydra vulgaris ) [TaxId: 6087 ],	SCOPe (2.08)
A	d1aeia_	All alpha proteins	Annexin	Annexin	Annexin	Annexin XII	(Hydra vulgaris ) [TaxId: 6087 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F	SCOP2B Superfamily	Annexin	8037804	3000627	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Annexin	8037804	3000627	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Annexin	8037804	3000627	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Annexin	8037804	3000627	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Annexin	8037804	3000627	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Annexin	8037804	3000627	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F	Annexin	e1aeiF2	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin	ECOD (1.6)
F	Annexin_1	e1aeiF4	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin_1	ECOD (1.6)
E	Annexin	e1aeiE2	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin	ECOD (1.6)
E	Annexin_1	e1aeiE4	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin_1	ECOD (1.6)
D	Annexin	e1aeiD2	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin	ECOD (1.6)
D	Annexin_1	e1aeiD4	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin_1	ECOD (1.6)
C	Annexin	e1aeiC2	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin	ECOD (1.6)
C	Annexin_1	e1aeiC4	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin_1	ECOD (1.6)
B	Annexin	e1aeiB2	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin	ECOD (1.6)
B	Annexin_1	e1aeiB4	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin_1	ECOD (1.6)
A	Annexin	e1aeiA2	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin	ECOD (1.6)
A	Annexin_1	e1aeiA4	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: Annexin_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
F	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
E	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
D	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
C	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
B	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
A	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00191	Annexin (Annexin)	Annexin	This family of annexins also includes giardin that has been shown to function as an annexin [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	ANNEXIN XII	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding calcium-dependent phospholipid binding phospholipid binding lipid binding modified amino acid binding anion binding phosphatidylserine binding	-	cell periphery cellular anatomical structure plasma membrane membrane intracellular anatomical structure cytoplasm membrane-bounded organelle vesicle membrane organelle vesicle organelle membrane intracellular organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR018502	Annexin repeat	Repeat
A, B, C, D, E A, B, C, D, E, F	IPR001464	Annexin	Family
A, B, C, D, E A, B, C, D, E, F	IPR018252	Annexin repeat, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR037104	Annexin superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.