1B0N | pdb_00001b0n

SINR PROTEIN/SINI PROTEIN COMPLEX

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1b0na1	All alpha proteins	Dimerisation interlock	SinR repressor dimerisation domain-like	SinR repressor dimerisation domain-like	SinR repressor dimerisation domain	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
A	d1b0na2	All alpha proteins	lambda repressor-like DNA-binding domains	lambda repressor-like DNA-binding domains	SinR domain-like	SinR repressor, DNA-binding domain	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
B	d1b0nb_	All alpha proteins	Dimerisation interlock	SinR repressor dimerisation domain-like	SinR repressor dimerisation domain-like	SinI anti-repressor	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SinR repressor dimerisation domain-like	8024745	4000886	SCOP2 (2022-06-29)
A	SCOP2 Family	SinR domain-like	8024810	4000896	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SinR repressor dimerisation domain-like	8037124	3001886	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	lambda C1 repressor DNA-binding domain-like	8037189	3000119	SCOP2 (2022-06-29)
B	SCOP2 Family	SinR repressor dimerisation domain-like	8024746	4000886	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	SinR repressor dimerisation domain-like	8037125	3001886	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HTH_3_1	e1b0nA1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: HTH_3_1	ECOD (1.6)
A	SinI	e1b0nA2	A: alpha duplicates or obligate multimers	X: Dimerisation interlock	H: SinR repressor dimerisation domain-like (From Topology)	T: SinR repressor dimerisation domain-like	F: SinI	ECOD (1.6)
B	SinI	e1b0nB1	A: alpha duplicates or obligate multimers	X: Dimerisation interlock	H: SinR repressor dimerisation domain-like (From Topology)	T: SinR repressor dimerisation domain-like	F: SinI	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.260.40	Mainly Alpha	Orthogonal Bundle	434 Repressor (Amino-terminal Domain)	lambda repressor-like DNA-binding domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01381	Helix-turn-helix (HTH_3)	Helix-turn-helix	This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be ...	This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family [1].	Domain
A	PF08671	Anti-repressor SinI (SinI)	Anti-repressor SinI	SinR is a pleiotropic regulator of several late growth processes. It is a tetrameric DNA binding protein whose activity is down-regulated thorough the formation of a SinI:SinR protein complex. When complexed with SinI, the SinR tetramer is disrupted ...	SinR is a pleiotropic regulator of several late growth processes. It is a tetrameric DNA binding protein whose activity is down-regulated thorough the formation of a SinI:SinR protein complex. When complexed with SinI, the SinR tetramer is disrupted such that is no longer able to bind DNA.	Domain
B	PF08671	Anti-repressor SinI (SinI)	Anti-repressor SinI	SinR is a pleiotropic regulator of several late growth processes. It is a tetrameric DNA binding protein whose activity is down-regulated thorough the formation of a SinI:SinR protein complex. When complexed with SinI, the SinR tetramer is disrupted ...	SinR is a pleiotropic regulator of several late growth processes. It is a tetrameric DNA binding protein whose activity is down-regulated thorough the formation of a SinI:SinR protein complex. When complexed with SinI, the SinR tetramer is disrupted such that is no longer able to bind DNA.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTEIN (SINR PROTEIN)	DNA binding binding nucleic acid binding transcription regulator activity DNA-binding transcription factor activity protein binding protein dimerization activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process negative regulation of gene expression sporulation resulting in formation of a cellular spore developmental process anatomical structure morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development sporulation	-
B	PROTEIN (SINI PROTEIN)	protein binding binding protein dimerization activity	regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process cellular process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR010981	SinR repressor/SinI anti-repressor, dimerisation domain	Domain
A	IPR001387	Cro/C1-type helix-turn-helix domain	Domain
A	IPR050807	Bacterial transcriptional regulator/dioxygenase	Family
A	IPR010982	Lambda repressor-like, DNA-binding domain superfamily	Homologous Superfamily
A	IPR036281	SinR repressor/SinI anti-repressor, dimerisation domain superfamily	Homologous Superfamily
B	IPR010981	SinR repressor/SinI anti-repressor, dimerisation domain	Domain
B	IPR036281	SinR repressor/SinI anti-repressor, dimerisation domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.