1B4K | pdb_00001b4k

High resolution crystal structure of a MG2-dependent 5-aminolevulinic acid dehydratase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1b4kb_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)	5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)	(Pseudomonas aeruginosa PAO1 ) [TaxId: 208964 ],	SCOPe (2.08)
A	d1b4ka_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)	5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)	(Pseudomonas aeruginosa PAO1 ) [TaxId: 208964 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Aldolase	8039349	3000445	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Aldolase	8039349	3000445	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	ALAD	e1b4kB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: ALAD	ECOD (1.6)
A	ALAD	e1b4kA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: ALAD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00490	Delta-aminolevulinic acid dehydratase (ALAD)	Delta-aminolevulinic acid dehydratase		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PROTEIN (5-AMINOLEVULINIC ACID DEHYDRATASE)	hydro-lyase activity lyase activity catalytic activity porphobilinogen synthase activity carbon-oxygen lyase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	porphyrin-containing compound biosynthetic process tetrapyrrole biosynthetic process tetrapyrrole metabolic process biosynthetic process metabolic process cellular process porphyrin-containing compound metabolic process heme metabolic process pigment metabolic process heme biosynthetic process pigment biosynthetic process protoporphyrinogen IX metabolic process protoporphyrinogen IX biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001731	Delta-aminolevulinic acid dehydratase	Family
A, B	IPR030656	Delta-aminolevulinic acid dehydratase, active site	Active Site
A, B	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.