1BCJ

MANNOSE-BINDING PROTEIN-A MUTANT (QPDWGHV) COMPLEXED WITH N-ACETYL-D-GALACTOSAMINE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth 2]	d1bcj21	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	Mannose-binding protein A, C-lectin domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B [auth 2]	d1bcj22	Coiled coil proteins	Parallel coiled-coil	Triple coiled coil domain of C-type lectins	Triple coiled coil domain of C-type lectins	Mannose-binding protein A	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A [auth 1]	d1bcj11	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	Mannose-binding protein A, C-lectin domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A [auth 1]	d1bcj12	Coiled coil proteins	Parallel coiled-coil	Triple coiled coil domain of C-type lectins	Triple coiled coil domain of C-type lectins	Mannose-binding protein A	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C [auth 3]	d1bcj31	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	Mannose-binding protein A, C-lectin domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C [auth 3]	d1bcj32	Coiled coil proteins	Parallel coiled-coil	Triple coiled coil domain of C-type lectins	Triple coiled coil domain of C-type lectins	Mannose-binding protein A	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth 2]	SCOP2B Superfamily	Triple coiled coil domain of C-type lectins	8039368	3001570	SCOP2B (2022-06-29)
B [auth 2]	SCOP2B Superfamily	C-type lectin-like	8037072	3001261	SCOP2B (2022-06-29)
A [auth 1]	SCOP2B Superfamily	C-type lectin-like	8037072	3001261	SCOP2B (2022-06-29)
A [auth 1]	SCOP2B Superfamily	Triple coiled coil domain of C-type lectins	8039368	3001570	SCOP2B (2022-06-29)
C [auth 3]	SCOP2B Superfamily	C-type lectin-like	8037072	3001261	SCOP2B (2022-06-29)
C [auth 3]	SCOP2B Superfamily	Triple coiled coil domain of C-type lectins	8039368	3001570	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth 2]	Lectin_C	e1bcj21	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
A [auth 1]	Lectin_C	e1bcj11	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
C [auth 3]	Lectin_C	e1bcj31	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth 2]	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
A [auth 1]	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
C [auth 3]	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth 1], B [auth 2], C [auth 3]	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 1], B [auth 2], C [auth 3]	MANNOSE-BINDING PROTEIN-A	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding enzyme binding protease binding oligosaccharide binding carbohydrate binding D-mannose binding monosaccharide binding identical protein binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding enzyme binding protease binding oligosaccharide binding carbohydrate binding D-mannose binding monosaccharide binding identical protein binding protein homodimerization activity protein dimerization activity phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol-4-phosphate binding phosphatidylinositol binding calcium-dependent carbohydrate binding polysaccharide binding calcium-dependent protein binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process immune response biological regulation immunoglobulin mediated immune response adaptive immune response immune effector process regulation of response to stimulus immune system process B cell mediated immunity regulation of immune response activation of immune response multicellular organismal process multicellular organismal-level homeostasis chemical homeostasis homeostatic process multicellular organismal-level chemical homeostasis surfactant homeostasis biological process involved in interspecies interaction between organisms response to biotic stimulus response to stress innate immune response response to external biotic stimulus complement activation, lectin pathway response to other organism defense response defense response to symbiont response to external stimulus defense response to other organism regulation of localization import into cell positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization transport vesicle-mediated transport cellular component organization localization positive regulation of endocytosis phagocytosis cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of phagocytosis positive regulation of transport cellular process endocytosis disruption of cell in another organism biological process involved in symbiotic interaction killing by host of symbiont cells disruption of anatomical structure in another organism biological process involved in interaction with symbiont killing of cells of another organism cell killing protein-containing complex organization protein trimerization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization defense response to Gram-positive bacterium defense response to bacterium response to bacterium	protein-containing complex collagen trimer membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle late endosome cytoplasm protein-containing complex collagen trimer membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle late endosome cytoplasm multivesicular body vesicle extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth 1], B [auth 2], C [auth 3]	IPR008160	Collagen triple helix repeat	Repeat
A [auth 1], B [auth 2], C [auth 3]	IPR051077	Calcium-dependent Lectin	Family
A [auth 1], B [auth 2], C [auth 3]	IPR016187	C-type lectin fold	Homologous Superfamily
A [auth 1], B [auth 2], C [auth 3]	IPR001304	C-type lectin-like	Domain
A [auth 1], B [auth 2], C [auth 3]	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A [auth 1], B [auth 2], C [auth 3]	IPR018378	C-type lectin, conserved site	Conserved Site
A [auth 1], B [auth 2], C [auth 3]	IPR033990	Collectin, C-type lectin-like domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.