Annotations: 1D66

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D [auth B]	d1d66b1	Small proteins	Zn2/Cys6 DNA-binding domain	Zn2/Cys6 DNA-binding domain	Zn2/Cys6 DNA-binding domain	Gal4	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
D [auth B]	d1d66b2	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	CD2-Gal4	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C [auth A]	d1d66a1	Small proteins	Zn2/Cys6 DNA-binding domain	Zn2/Cys6 DNA-binding domain	Zn2/Cys6 DNA-binding domain	Gal4	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C [auth A]	d1d66a2	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	CD2-Gal4	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D [auth B]	SCOP2B Superfamily	Zn2/Cys6 DNA-binding domain	8040225	3001104	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	Zn2/Cys6 DNA-binding domain	8040225	3001104	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth B]	Zn_clus_1	e1d66B1	A: few secondary structure elements	X: Zn2/Cys6 DNA-binding domain (From Topology)	H: Zn2/Cys6 DNA-binding domain (From Topology)	T: Zn2/Cys6 DNA-binding domain	F: Zn_clus_1	ECOD (1.6)
C [auth A]	Zn_clus_1	e1d66A1	A: few secondary structure elements	X: Zn2/Cys6 DNA-binding domain (From Topology)	H: Zn2/Cys6 DNA-binding domain (From Topology)	T: Zn2/Cys6 DNA-binding domain	F: Zn_clus_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D [auth B]	4.10.240.10	Few Secondary Structures	Irregular	CD2-Gal4	Zn(2)-C6 fungal-type DNA-binding domain	CATH (4.3.0)
D [auth B]	1.20.5.640	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Single helix bin	CATH (4.3.0)
C [auth A]	4.10.240.10	Few Secondary Structures	Irregular	CD2-Gal4	Zn(2)-C6 fungal-type DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth B]	PF00172	Fungal Zn(2)-Cys(6) binuclear cluster domain (Zn_clus)	Fungal Zn(2)-Cys(6) binuclear cluster domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D]	DNA (5'-D(CPCPGPGPAPGPGPAPCPAPGPTPCPCPTPCPC PGP*G)-3')	-	-	-
B [auth E]	DNA (5'-D(CPCPGPGPAPGPGPAPCPTPGPTPCPCPTPCPC PGP*G)-3')	-	-	-
C [auth A], D [auth B]	PROTEIN (GAL4)	DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding	cellular response to stimulus regulation of cellular process response to stimulus regulation of transcription from RNA polymerase II promoter by galactose carbon catabolite regulation of transcription positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process cellular response to stimulus regulation of cellular process response to stimulus regulation of transcription from RNA polymerase II promoter by galactose carbon catabolite regulation of transcription positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by galactose primary metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression cellular response to nutrient levels carbon catabolite regulation of transcription from RNA polymerase II promoter biosynthetic process carbon catabolite activation of transcription from RNA polymerase II promoter response to chemical metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process carbon catabolite activation of transcription response to nutrient levels positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of transcription by galactose regulation of biosynthetic process biological regulation response to nutrient regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of transcription from RNA polymerase II promoter by galactose cellular response to chemical stimulus positive regulation of RNA biosynthetic process cellular process cellular response to nutrient monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process galactose metabolic process	protein-containing complex transcription regulator complex transcription repressor complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth B]	IPR051127	Fungal Secondary Metabolite Regulators	Family
C [auth A], D [auth B]	IPR036864	Zn(2)-C6 fungal-type DNA-binding domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR007219	Transcription factor domain, fungi	Domain
C [auth A], D [auth B]	IPR001138	Zn(2)Cys(6) fungal-type DNA-binding domain	Domain
C [auth A], D [auth B]	IPR005600	Gal4 dimerisation domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.