Annotations: 1DVK

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1dvka_	All alpha proteins	Functional domain of the splicing factor Prp18	Functional domain of the splicing factor Prp18	Functional domain of the splicing factor Prp18	Functional domain of the splicing factor Prp18	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d1dvkb_	All alpha proteins	Functional domain of the splicing factor Prp18	Functional domain of the splicing factor Prp18	Functional domain of the splicing factor Prp18	Functional domain of the splicing factor Prp18	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Functional domain of the splicing factor Prp18	8037866	3000735	SCOP2B (2022-06-29)
B	SCOP2 Family	Functional domain of the splicing factor Prp18	8025487	4001092	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Functional domain of the splicing factor Prp18	8037866	3000735	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Prp18	e1dvkA1	A: alpha bundles	X: Functional domain of the splicing factor Prp18 (From Topology)	H: Functional domain of the splicing factor Prp18 (From Topology)	T: Functional domain of the splicing factor Prp18	F: Prp18	ECOD (1.6)
B	Prp18	e1dvkB1	A: alpha bundles	X: Functional domain of the splicing factor Prp18 (From Topology)	H: Functional domain of the splicing factor Prp18 (From Topology)	T: Functional domain of the splicing factor Prp18	F: Prp18	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.940.10	Mainly Alpha	Up-down Bundle	RNA Binding Protein, Prp18	Chain A	CATH (4.3.0)
B	1.20.940.10	Mainly Alpha	Up-down Bundle	RNA Binding Protein, Prp18	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02840	Prp18 domain (Prp18)	Prp18 domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PRP18	-	regulation of cellular process catabolic process negative regulation of biological process RNA metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process negative regulation of cellular process RNA surveillance RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process nuclear RNA surveillance nuclear-transcribed mRNA catabolic process regulation of cellular process catabolic process negative regulation of biological process RNA metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process negative regulation of cellular process RNA surveillance RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process nuclear RNA surveillance nuclear-transcribed mRNA catabolic process regulation of biological process negative regulation of metabolic process nuclear mRNA surveillance biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process nucleic acid metabolic process nucleobase-containing compound catabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process RNA splicing nucleobase-containing compound biosynthetic process mRNA processing RNA biosynthetic process nucleic acid biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis generation of catalytic spliceosome for second transesterification step protein-containing complex organization spliceosomal conformational changes to generate catalytic conformation	U5 snRNP membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U5 snRNP membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U2-type spliceosomal complex post-spliceosomal complex spliceosomal complex U2-type post-spliceosomal complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR039979	Pre-mRNA-splicing factor 18	Family
A, B	IPR004098	Prp18	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.