1EKZ | pdb_00001ekz

NMR STRUCTURE OF THE COMPLEX BETWEEN THE THIRD DSRBD FROM DROSOPHILA STAUFEN AND A RNA HAIRPIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d1ekza_	Alpha and beta proteins (a+b)	dsRBD-like	dsRNA-binding domain-like	Double-stranded RNA-binding domain (dsRBD)	Staufen, domain III	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2 Family	Double-stranded RNA-binding domain (dsRBD)	8022709	4001172	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	dsRNA-binding domain-like	8035089	3000985	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	dsrm	e1ekzA1	A: a+b two layers	X: dsRBD-like	H: dsRNA-binding domain-like (From Topology)	T: dsRNA-binding domain-like	F: dsrm	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	3.30.160.20	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A]	PF00035	Double-stranded RNA binding motif (dsrm)	Double-stranded RNA binding motif	Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localisation of at least five d ...	Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localisation of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	STAUFEN DOUBLE-STRANDED RNA BINDING DOMAIN	-	-	-
B [auth A]	MATERNAL EFFECT PROTEIN (STAUFEN)	RNA binding binding lncRNA binding nucleic acid binding double-stranded RNA binding mRNA 3'-UTR binding mRNA binding	localization macromolecule localization RNA localization developmental process sexual reproduction cellular developmental process reproductive process oogenesis multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction female gamete generation gamete generation localization macromolecule localization RNA localization developmental process sexual reproduction cellular developmental process reproductive process oogenesis multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction female gamete generation gamete generation cell differentiation anatomical structure development germ cell development cellular process anterograde dendritic transport cellular localization transport intracellular transport dendritic transport establishment of localization axo-dendritic transport establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process anterograde dendritic transport of messenger ribonucleoprotein complex multicellular organismal process blastoderm segmentation bicoid mRNA localization anterior/posterior pattern specification anterior/posterior axis specification, embryo segmentation pattern specification process embryo development oocyte development tripartite regional subdivision embryonic axis specification multicellular organism development anterior/posterior axis specification cell maturation embryonic pattern specification oocyte axis specification oocyte construction intracellular mRNA localization oocyte anterior/posterior axis specification developmental maturation regionalization anatomical structure maturation maternal determination of anterior/posterior axis, embryo intracellular mRNA localization involved in pattern specification process oocyte differentiation intracellular mRNA localization involved in anterior/posterior axis specification axis specification cellular component biogenesis cellular component organization cellular component assembly cellular component organization or biogenesis cytoplasm organization pole plasm assembly asymmetric protein localization involved in cell fate determination intracellular protein localization cell fate determination cell fate commitment pole plasm protein localization protein localization to synapse protein localization to cell junction pole plasm RNA localization behavior system process learning or memory long-term memory nervous system process cognition memory positive regulation of organelle organization regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization positive regulation of cytoplasmic mRNA processing body assembly regulation of cytoplasmic mRNA processing body assembly positive regulation of biological process membraneless organelle assembly positive regulation of cellular process regulation of biological process organelle assembly P-body assembly positive regulation of cellular component biogenesis biological regulation regulation of cellular component biogenesis regulation of organelle organization organelle organization regulation of organelle assembly positive regulation of organelle assembly neuroblast fate commitment neuroblast differentiation nervous system development generation of neurons neurogenesis neuroblast fate determination system development positive regulation of neuromuscular junction development positive regulation of nervous system development regulation of growth developmental growth positive regulation of developmental process neuromuscular junction development regulation of synaptic assembly at neuromuscular junction regulation of synapse structure or activity synapse organization regulation of biological quality regulation of neuromuscular junction development positive regulation of developmental growth positive regulation of synaptic assembly at neuromuscular junction regulation of cell junction assembly positive regulation of multicellular organismal process synapse assembly positive regulation of synapse assembly regulation of developmental process regulation of nervous system development cell junction assembly regulation of multicellular organismal process regulation of synapse assembly regulation of multicellular organismal development regulation of developmental growth growth regulation of synapse organization positive regulation of cell junction assembly positive regulation of growth cell junction organization synaptic assembly at neuromuscular junction regulation of localization pole plasm oskar mRNA localization pole plasm mRNA localization regulation of intracellular mRNA localization regulation of pole plasm oskar mRNA localization protein biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression protein metabolic process regulation of biosynthetic process regulation of oskar mRNA translation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of translation regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process	cellular anatomical structure intracellular anatomical structure pole plasm germ plasm cytoplasm cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle organelle membraneless organelle supramolecular complex cytoplasmic stress granule cell periphery cellular anatomical structure intracellular anatomical structure pole plasm germ plasm cytoplasm cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle organelle membraneless organelle supramolecular complex cytoplasmic stress granule cell periphery cell cortex basal part of cell cell cortex region cytoplasmic region basal cortex apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane basal plasma membrane posterior cell cortex neuron projection cytoplasm neuron projection plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection dendrite cytoplasm somatodendritic compartment cell projection dendrite dendritic tree neuronal ribonucleoprotein granule membrane-bounded organelle axon synapse axon terminus intracellular membrane-bounded organelle subsynaptic reticulum presynapse distal axon terminal bouton cell junction neuron projection terminus type I terminal bouton cell body neuronal cell body P-body apical cortex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth A]	IPR051740	Double-stranded RNA-binding domain-containing protein	Family
B [auth A]	IPR032478	Staufen, C-terminal	Domain
B [auth A]	IPR014720	Double-stranded RNA-binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.