1IVZ | pdb_00001ivz

Solution structure of the SEA domain from murine hypothetical protein homologous to human mucin 16

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ivza1	Alpha and beta proteins (a+b)	Ferredoxin-like	SEA domain	SEA domain	SEA domain from the hypothetical protein homologous to mucin 16	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1ivza3	Artifacts	Tags	Tags	Tags	C-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1ivza2	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SEA domain	8030136	4003231	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SEA domain	8042515	3000461	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SEA	e1ivzA1	A: a+b two layers	X: Alpha-beta plaits	H: SEA domain (From Topology)	T: SEA domain	F: SEA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.70.960	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	SEA domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01390	SEA domain (SEA)	SEA domain	Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain [4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	hypothetical protein 1110008I14RIK	-	negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process biological regulation negative regulation of biological process regulation of cell population proliferation negative regulation of cellular process cellular process regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation wound healing response to stimulus negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process biological regulation negative regulation of biological process regulation of cell population proliferation negative regulation of cellular process cellular process regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation wound healing response to stimulus regulation of response to external stimulus negative regulation of response to stimulus negative regulation of wound healing response to external stimulus negative regulation of response to wounding regulation of response to wounding regulation of response to stimulus response to stress regulation of response to stress negative regulation of response to external stimulus regulation of wound healing response to wounding interleukin-6 production multicellular organismal process regulation of interleukin-6 production regulation of cytokine production cytokine production regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of interleukin-6 production negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036364	SEA domain superfamily	Homologous Superfamily
A	IPR028850	Mucin-16	Family
A	IPR000082	SEA domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.