1LML | pdb_00001lml

LEISHMANOLYSIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1lmla_	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	Leishmanolysin	Leishmanolysin	(Leishmania major ) [TaxId: 5664 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Leishmanolysin	8023080	4001619	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Metalloproteases (zincins), catalytic domain	8035460	3001975	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_M8	e1lmlA1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M8	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.170.20	Alpha Beta	Roll	Elastase	domain 1	CATH (4.3.0)
A	3.90.132.10	Alpha Beta	Alpha-Beta Complex	Leishmanolysin	domain 2	CATH (4.3.0)
A	2.10.55.10	Mainly Beta	Ribbon	Leishmanolysin	domain 3	CATH (4.3.0)
A	2.30.34.10	Mainly Beta	Roll	Leishmanolysin	domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01457	Leishmanolysin (Peptidase_M8)	Leishmanolysin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	LEISHMANOLYSIN	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding metalloendopeptidase activity endopeptidase activity	symbiont-mediated perturbation of host defense response biological process involved in interspecies interaction between organisms symbiont-mediated suppression of host complement activation symbiont-mediated perturbation of host immune response symbiont-mediated suppression of host complement activation by inactivation of complement proteins biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated perturbation of host process symbiont-mediated perturbation of host innate immune response modulation of process of another organism symbiont-mediated perturbation of host inflammatory response proteolysis symbiont-mediated perturbation of host defense response biological process involved in interspecies interaction between organisms symbiont-mediated suppression of host complement activation symbiont-mediated perturbation of host immune response symbiont-mediated suppression of host complement activation by inactivation of complement proteins biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated perturbation of host process symbiont-mediated perturbation of host innate immune response modulation of process of another organism symbiont-mediated perturbation of host inflammatory response proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process symbiont-mediated perturbation of host cellular process symbiont-mediated activation of host signal transduction pathway symbiont-mediated perturbation of host signal transduction pathway cell adhesion symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host JAK-STAT cascade	cellular anatomical structure membrane side of membrane cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001577	Peptidase M8, leishmanolysin	Family

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	leishmanolysin M-CSA #668	Leishmania is a protozoan parasite transmitted from sandfly vector to human and other mammalian hosts causing chronic infections. It exists as extracellular promastigotes within sandflies and intracellular amastigotes within macrophage cells of mammals. Leishmanolysin is the major protein component of the Leishmania promastigote surface. It is characterised as a zinc metalloproteinase containing a glycosyl phosphatidyl inositol membrane anchor. It is an endopeptidase cleaving a variety of substrate. Its role in the life cycle Leishmania remains to be established.	Defined by 4 residues: HIS:A-165 [auth A-264]GLU:A-166 [auth A-265]HIS:A-169 [auth A-268]HIS:A-235 [auth A-334] \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 3.4.24.36 (PDB Primary Data) Search M-CSA Motif + EC 3.4.24.36

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.