1M5N | pdb_00001m5n

Crystal structure of HEAT repeats (1-11) of importin b bound to the non-classical NLS(67-94) of PTHrP

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth S]	d1m5ns_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	Importin beta	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth S]	IBN_N	e1m5nS1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: IBN_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth S]	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth S]	PF00514	Armadillo/beta-catenin-like repeat (Arm)	Armadillo/beta-catenin-like repeat	-	Repeat
A [auth S]	PF03810	Importin-beta N-terminal domain (IBN_N)	Importin-beta N-terminal domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth S]	Importin beta-1 subunit	small GTPase binding protein binding binding enzyme binding GTPase binding protein domain specific binding Hsp90 protein binding heat shock protein binding RNA binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding nuclear import signal receptor activity small GTPase binding protein binding binding enzyme binding GTPase binding protein domain specific binding Hsp90 protein binding heat shock protein binding RNA binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity importin-alpha family protein binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular localization RNA import into nucleus RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport nucleic acid transport intracellular transport establishment of localization localization import into nucleus establishment of RNA localization macromolecule localization establishment of localization in cell cellular localization RNA import into nucleus RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport nucleic acid transport intracellular transport establishment of localization localization import into nucleus establishment of RNA localization macromolecule localization establishment of localization in cell cellular process RNA localization nucleobase-containing compound transport mitotic cell cycle cellular component organization mitotic chromosome movement towards spindle pole chromosome localization organelle localization mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation chromosome movement towards spindle pole cell cycle process mitotic nuclear division organelle fission chromosome organization sister chromatid segregation organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation microtubule-based movement microtubule-based process establishment of organelle localization mitotic metaphase chromosome alignment metaphase chromosome alignment establishment of chromosome localization regulation of steroid biosynthetic process regulation of cholesterol biosynthetic process regulation of cellular process regulation of cholesterol metabolic process steroid metabolic process regulation of lipid metabolic process sterol metabolic process positive regulation of biological process cholesterol metabolic process lipid biosynthetic process alcohol metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of small molecule metabolic process positive regulation of biosynthetic process positive regulation of lipid metabolic process small molecule metabolic process steroid biosynthetic process positive regulation of cellular process regulation of biosynthetic process secondary alcohol biosynthetic process regulation of biological process regulation of alcohol biosynthetic process small molecule biosynthetic process regulation of steroid metabolic process cholesterol biosynthetic process positive regulation of cholesterol biosynthetic process biological regulation primary metabolic process secondary alcohol metabolic process positive regulation of steroid biosynthetic process biosynthetic process sterol biosynthetic process positive regulation of lipid biosynthetic process regulation of sterol biosynthetic process alcohol biosynthetic process positive regulation of cholesterol metabolic process positive regulation of steroid metabolic process metabolic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process regulation of metabolic process positive regulation of alcohol biosynthetic process positive regulation of sterol biosynthetic process lipid metabolic process microtubule cytoskeleton organization spindle localization establishment of mitotic spindle localization establishment of spindle localization microtubule cytoskeleton organization involved in mitosis cytoskeleton organization protein localization establishment of protein localization protein localization to nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport astral microtubule organization cytoplasmic microtubule organization supramolecular fiber organization spindle organization NLS-bearing protein import into nucleus membraneless organelle assembly cellular component biogenesis cellular component assembly organelle assembly spindle assembly mitotic spindle organization mitotic spindle assembly ribosomal protein import into nucleus	intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule protein-containing complex nucleocytoplasmic transport complex NLS-dependent protein nuclear import complex intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule protein-containing complex nucleocytoplasmic transport complex NLS-dependent protein nuclear import complex membrane membrane-bounded organelle organelle envelope nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol nuclear protein-containing complex nuclear pore membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular organelle lumen organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle nucleoplasm nuclear lumen organelle subcompartment endoplasmic reticulum subcompartment endoplasmic reticulum endoplasmic reticulum tubular network vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule
B [auth Q]	Parathyroid hormone-related protein	molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity hormone activity protein binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity peptide hormone receptor binding hormone receptor binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction cell population proliferation positive regulation of cell population proliferation cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of biological process positive regulation of cellular process developmental process multicellular organismal process ossification bone mineralization animal organ development anatomical structure development biomineral tissue development tissue development multi-multicellular organism process reproductive process female pregnancy multi-organism reproductive process negative regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process multicellular organism development skeletal system development system development regulation of chondrocyte differentiation regulation of cartilage development regulation of developmental process cellular developmental process connective tissue development negative regulation of cartilage development cell development regulation of cell differentiation negative regulation of chondrocyte differentiation negative regulation of chondrocyte development regulation of cell development regulation of chondrocyte development cell differentiation negative regulation of cell differentiation regulation of multicellular organismal process regulation of multicellular organismal development negative regulation of developmental process negative regulation of cell development chondrocyte differentiation negative regulation of multicellular organismal process chondrocyte development cartilage development regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process epidermis development cell-cell signaling nucleoside phosphate metabolic process ribose phosphate metabolic process cAMP metabolic process cyclic purine nucleotide metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process cyclic nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process purine ribonucleotide metabolic process phosphorus metabolic process osteoblast development osteoblast differentiation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system extracellular region cytosol extracellular space nucleus membrane-enclosed lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system extracellular region cytosol extracellular space nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth S]	IPR016024	Armadillo-type fold	Homologous Superfamily
A [auth S]	IPR021133	HEAT, type 2	Repeat
A [auth S]	IPR000225	Armadillo	Repeat
A [auth S]	IPR001494	Importin-beta, N-terminal domain	Domain
A [auth S]	IPR011989	Armadillo-like helical	Homologous Superfamily
A [auth S]	IPR040122	Importin beta family	Family
B [auth Q]	IPR001415	Parathyroid hormone/parathyroid hormone-related protein	Family
B [auth Q]	IPR003626	Parathyroid hormone-related protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth S]	Pharos: Q14974	HIV infectious disease subependymal giant cell astrocytoma astrocytic tumor dental caries Hashimoto thyroiditis large cell medulloblastoma lymphoplasmacytic lymphoma osteosarcoma Pick disease atypical teratoid rhabdoid tumor dermatomyositis HIV Coinfection lung adenocarcinoma malignant glioma ovarian cancer HIV infectious disease subependymal giant cell astrocytoma astrocytic tumor dental caries Hashimoto thyroiditis large cell medulloblastoma lymphoplasmacytic lymphoma osteosarcoma Pick disease atypical teratoid rhabdoid tumor dermatomyositis HIV Coinfection lung adenocarcinoma malignant glioma ovarian cancer psoriasis glioblastoma lung cancer medulloblastoma pancreatic ductal adenocarcinoma
B [auth Q]	Pharos: P12272	brachydactyly type E2 hypercalcemia disease breast carcinoma non-small cell lung carcinoma plasma cell myeloma neuroendocrine neoplasm prostate cancer alcoholic pancreatitis Edema superior vena cava syndrome malignant pancreatic neoplasm chronic pancreatitis acute pancreatitis breast cancer osteoarthritis brachydactyly type E2 hypercalcemia disease breast carcinoma non-small cell lung carcinoma plasma cell myeloma neuroendocrine neoplasm prostate cancer alcoholic pancreatitis Edema superior vena cava syndrome malignant pancreatic neoplasm chronic pancreatitis acute pancreatitis breast cancer osteoarthritis cystic fibrosis pilocytic astrocytoma hyperparathyroidism lung cancer asthma brachydactyly type E cancer ovarian cancer genetic endocrine growth disease IgA glomerulonephritis triple-negative breast carcinoma lung disease astrocytic tumor lytic metastatic bone lesion bone resorption disease breast fibroadenoma myeloid neoplasm oligodendroglioma cutaneous lupus erythematosus pancreatic neoplasm estrogen-receptor negative breast cancer plasma cell neoplasm sinusitis intellectual disability atypical teratoid rhabdoid tumor medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.