1OTG | pdb_00001otg

5-CARBOXYMETHYL-2-HYDROXYMUCONATE ISOMERASE

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1otga_ Alpha and beta proteins (a+b) Tautomerase/MIF Tautomerase/MIF 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) (Escherichia coli C ) [TaxId: 498388 ], SCOPe (2.08)
Bd1otgb_ Alpha and beta proteins (a+b) Tautomerase/MIF Tautomerase/MIF 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) (Escherichia coli C ) [TaxId: 498388 ], SCOPe (2.08)
Cd1otgc_ Alpha and beta proteins (a+b) Tautomerase/MIF Tautomerase/MIF 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) (Escherichia coli C ) [TaxId: 498388 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 Family5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) 8023674 4001529 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyTautomerase/MIF 8036054 3001770 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyTautomerase/MIF 8036054 3001770 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyTautomerase/MIF 8036054 3001770 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ACHMIe1otgA1 A: a+b two layersX: Tautomerase/MIF-likeH: Tautomerase/MIF (From Topology)T: Tautomerase/MIFF: CHMIECOD (1.6)
BCHMIe1otgB1 A: a+b two layersX: Tautomerase/MIF-likeH: Tautomerase/MIF (From Topology)T: Tautomerase/MIFF: CHMIECOD (1.6)
CCHMIe1otgC1 A: a+b two layersX: Tautomerase/MIF-likeH: Tautomerase/MIF (From Topology)T: Tautomerase/MIFF: CHMIECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.429.10 Alpha Beta 2-Layer Sandwich Macrophage Migration Inhibitory Factor Macrophage Migration Inhibitory FactorCATH (4.3.0)
B3.30.429.10 Alpha Beta 2-Layer Sandwich Macrophage Migration Inhibitory Factor Macrophage Migration Inhibitory FactorCATH (4.3.0)
C3.30.429.10 Alpha Beta 2-Layer Sandwich Macrophage Migration Inhibitory Factor Macrophage Migration Inhibitory FactorCATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C
5-CARBOXYMETHYL-2-HYDROXYMUCONATE ISOMERASE - -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C
IPR014347Tautomerase/MIF superfamilyHomologous Superfamily
A, B, C
IPR0042205-carboxymethyl-2-hydroxymuconate isomeraseFamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
5-carboxymethyl-2-hydroxymuconate Delta-isomerase  M-CSA #874

5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) transforms 5-carboxymethyl-2-hydroxy-muconic acid into 5-oxo-pent-3-ene-1,2,5-tricarboxylic acid during the third step of the homoprotocatechuate catabolic pathway [PMID:2194841]. CHMI is a member of the tautomerase superfamily many of which utilise a unique N-terminal proline residue as a general acid/base.

Defined by 4 residues: PRO:A-1 [auth A-2]PRO:A-35 [auth A-36]ARG:A-40 [auth A-41]ARG:A-71 [auth A-72]
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Explore in 3D: M-CSA Motif Definition
Search M-CSA Motif
EC: 5.3.2 (PDB Primary Data)
EC: 5.3.3.10 (UniProt)