1PZQ | pdb_00001pzq

Structure of fused docking domains from the erythromycin polyketide synthase (DEBS), a model for the interaction between DEBS 2 and DEBS 3: The A domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1pzqb1	All alpha proteins	Dimerisation interlock	Docking domain A of the erythromycin polyketide synthase (DEBS)	Docking domain A of the erythromycin polyketide synthase (DEBS)	Erythronolide synthase	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
B	d1pzqb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
A	d1pzqa1	All alpha proteins	Dimerisation interlock	Docking domain A of the erythromycin polyketide synthase (DEBS)	Docking domain A of the erythromycin polyketide synthase (DEBS)	Erythronolide synthase	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
A	d1pzqa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Docking domain A of the erythromycin polyketide synthase (DEBS)	8039464	3000887	SCOP2B (2022-06-29)
A	SCOP2 Family	Docking domain A of the erythromycin polyketide synthase (DEBS)	8027085	4000653	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Docking domain A of the erythromycin polyketide synthase (DEBS)	8039464	3000887	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	UNK_F_TYPE	e1pzqB1	A: alpha duplicates or obligate multimers	X: Dimerisation interlock	H: Docking domain A of the erythromycin polyketide synthase (DEBS) (From Topology)	T: Docking domain A of the erythromycin polyketide synthase (DEBS)	F: UNK_F_TYPE	ECOD (1.6)
A	UNK_F_TYPE	e1pzqA1	A: alpha duplicates or obligate multimers	X: Dimerisation interlock	H: Docking domain A of the erythromycin polyketide synthase (DEBS) (From Topology)	T: Docking domain A of the erythromycin polyketide synthase (DEBS)	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.5.1140	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Docking domain of the erythromycin polyketide synthase (DEBS)	CATH (4.3.0)
A	1.20.5.1140	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Docking domain of the erythromycin polyketide synthase (DEBS)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF09277	Erythronolide synthase, docking (Erythro-docking)	Erythronolide synthase, docking	Members of this family of docking domains are found in prokaryotic erythronolide synthase. They adopt a structure consisting of a bundle of four alpha-helices, and mediate homodimerisation of the protein, stabilising the resulting complex [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Erythronolide synthase	oxidoreductase activity catalytic activity vitamin binding amide binding modified amino acid binding binding phosphopantetheine binding small molecule binding acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity erythronolide synthase activity fatty acid synthase activity	fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process macrolide biosynthetic process polyketide metabolic process macrolide metabolic process secondary metabolic process antibiotic biosynthetic process antibiotic metabolic process polyketide biosynthetic process secondary metabolite biosynthetic process lactone metabolic process lactone biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
A, B	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
A, B	IPR015083	Polyketide synthase NorB/C/GfsB-E-like, docking domain	Domain
A, B	IPR006162	Phosphopantetheine attachment site	PTM
A, B	IPR013154	Alcohol dehydrogenase-like, N-terminal	Domain
A, B	IPR036347	Erythronolide synthase, docking domain superfamily	Homologous Superfamily
A, B	IPR049552	Polyketide synthase, dehydratase domain, N-terminal	Domain
A, B	IPR049900	Polyketide synthase, dehydratase domain	Domain
A, B	IPR049551	Polyketide synthase, dehydratase domain, C-terminal	Domain
A, B	IPR016036	Malonyl-CoA ACP transacylase, ACP-binding	Homologous Superfamily
A, B	IPR050091	Polyketide and Nonribosomal Peptide Biosynthesis Enzymes	Family
A, B	IPR015357	Erythronolide synthase EryA2, docking domain	Domain
A, B	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
A, B	IPR020807	Polyketide/metazoan fatty acid synthase-like, dehydratase domain	Domain
A, B	IPR036736	ACP-like superfamily	Homologous Superfamily
A, B	IPR014043	Acyl transferase domain	Domain
A, B	IPR020843	Enoylreductase domain	Domain
A, B	IPR032821	Polyketide synthase, C-terminal extension	Domain
A, B	IPR011032	GroES-like superfamily	Homologous Superfamily
A, B	IPR009081	Phosphopantetheine binding ACP domain	Domain
A, B	IPR020806	Polyketide synthase-like, phosphopantetheine-binding domain	Domain
A, B	IPR013968	Polyketide synthase-like, ketoreductase domain	Domain
A, B	IPR016039	Thiolase-like	Homologous Superfamily
A, B	IPR001227	Acyl transferase domain superfamily	Homologous Superfamily
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR018201	Beta-ketoacyl synthase, active site	Active Site
A, B	IPR014030	Beta-ketoacyl synthase-like, N-terminal	Domain
A, B	IPR042104	Polyketide synthase, dehydratase domain superfamily	Homologous Superfamily
A, B	IPR055123	Polyketide synthase extender module SpnB-like, Rossmann fold domain	Domain