1T36
Crystal structure of E. coli carbamoyl phosphate synthetase small subunit mutant C248D complexed with uridine 5'-monophosphate
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Glutathione synthetase ATP-binding domain-like | 8036563 | 3000094 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Carbamoyl phosphate synthetase, large subunit connection domain | 8038131 | 3000839 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Methylglyoxal synthase-like | 8044174 | 3001443 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | PreATP-grasp domain | 8044230 | 3001680 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | PreATP-grasp domain | 8044232 | 3001680 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Glutathione synthetase ATP-binding domain-like | 8036561 | 3000094 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Glutathione synthetase ATP-binding domain-like | 8036563 | 3000094 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Glutathione synthetase ATP-binding domain-like | 8036561 | 3000094 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Methylglyoxal synthase-like | 8044174 | 3001443 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | PreATP-grasp domain | 8044230 | 3001680 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | PreATP-grasp domain | 8044232 | 3001680 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Carbamoyl phosphate synthetase, large subunit connection domain | 8038131 | 3000839 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | Glutathione synthetase ATP-binding domain-like | 8036561 | 3000094 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | Methylglyoxal synthase-like | 8044174 | 3001443 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | Glutathione synthetase ATP-binding domain-like | 8036563 | 3000094 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | PreATP-grasp domain | 8044230 | 3001680 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | PreATP-grasp domain | 8044232 | 3001680 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | Carbamoyl phosphate synthetase, large subunit connection domain | 8038131 | 3000839 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Glutathione synthetase ATP-binding domain-like | 8036561 | 3000094 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Glutathione synthetase ATP-binding domain-like | 8036563 | 3000094 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | PreATP-grasp domain | 8044232 | 3001680 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Carbamoyl phosphate synthetase, large subunit connection domain | 8038131 | 3000839 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | PreATP-grasp domain | 8044230 | 3001680 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Methylglyoxal synthase-like | 8044174 | 3001443 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Carbamoyl phosphate synthetase, small subunit N-terminal domain | 8043909 | 3000949 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Class I glutamine amidotransferase-like | 8044144 | 3001405 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Carbamoyl phosphate synthetase, small subunit N-terminal domain | 8043909 | 3000949 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Class I glutamine amidotransferase-like | 8044144 | 3001405 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | Carbamoyl phosphate synthetase, small subunit N-terminal domain | 8043909 | 3000949 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | Class I glutamine amidotransferase-like | 8044144 | 3001405 | SCOP2B (2022-06-29) |
H | SCOP2B Superfamily | Carbamoyl phosphate synthetase, small subunit N-terminal domain | 8043909 | 3000949 | SCOP2B (2022-06-29) |
H | SCOP2B Superfamily | Class I glutamine amidotransferase-like | 8044144 | 3001405 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | CPSase_L_D3 | e1t36A1 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: CPSase_L_D3 | ECOD (1.6) |
A | ATP-grasp | e1t36A2 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: ATP-grasp | F: ATP-grasp | ECOD (1.6) |
A | carB | e1t36A4 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: PreATP-grasp domain | F: carB | ECOD (1.6) |
A | MGS | e1t36A6 | A: a/b three-layered sandwiches | X: Methylglyoxal synthase-like (From Topology) | H: Methylglyoxal synthase-like (From Topology) | T: Methylglyoxal synthase-like | F: MGS | ECOD (1.6) |
C | CPSase_L_D3 | e1t36C1 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: CPSase_L_D3 | ECOD (1.6) |
C | ATP-grasp | e1t36C2 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: ATP-grasp | F: ATP-grasp | ECOD (1.6) |
C | carB | e1t36C4 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: PreATP-grasp domain | F: carB | ECOD (1.6) |
C | MGS | e1t36C6 | A: a/b three-layered sandwiches | X: Methylglyoxal synthase-like (From Topology) | H: Methylglyoxal synthase-like (From Topology) | T: Methylglyoxal synthase-like | F: MGS | ECOD (1.6) |
G | CPSase_L_D3 | e1t36G1 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: CPSase_L_D3 | ECOD (1.6) |
G | ATP-grasp | e1t36G2 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: ATP-grasp | F: ATP-grasp | ECOD (1.6) |
G | carB | e1t36G4 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: PreATP-grasp domain | F: carB | ECOD (1.6) |
G | MGS | e1t36G6 | A: a/b three-layered sandwiches | X: Methylglyoxal synthase-like (From Topology) | H: Methylglyoxal synthase-like (From Topology) | T: Methylglyoxal synthase-like | F: MGS | ECOD (1.6) |
E | CPSase_L_D3 | e1t36E1 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: CPSase_L_D3 | ECOD (1.6) |
E | ATP-grasp | e1t36E2 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: ATP-grasp | F: ATP-grasp | ECOD (1.6) |
E | carB | e1t36E4 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: PreATP-grasp domain | F: carB | ECOD (1.6) |
E | MGS | e1t36E6 | A: a/b three-layered sandwiches | X: Methylglyoxal synthase-like (From Topology) | H: Methylglyoxal synthase-like (From Topology) | T: Methylglyoxal synthase-like | F: MGS | ECOD (1.6) |
B | GATase | e1t36B1 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Class I glutamine amidotransferase-like | T: Class I glutamine amidotransferase-like | F: GATase | ECOD (1.6) |
B | CPSase_sm_chain | e1t36B2 | A: a/b three-layered sandwiches | X: The swivelling beta/beta/alpha domains | H: The swivelling beta/beta/alpha domain (From Topology) | T: The swivelling beta/beta/alpha domain | F: CPSase_sm_chain | ECOD (1.6) |
D | GATase | e1t36D1 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Class I glutamine amidotransferase-like | T: Class I glutamine amidotransferase-like | F: GATase | ECOD (1.6) |
D | CPSase_sm_chain | e1t36D2 | A: a/b three-layered sandwiches | X: The swivelling beta/beta/alpha domains | H: The swivelling beta/beta/alpha domain (From Topology) | T: The swivelling beta/beta/alpha domain | F: CPSase_sm_chain | ECOD (1.6) |
F | GATase | e1t36F1 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Class I glutamine amidotransferase-like | T: Class I glutamine amidotransferase-like | F: GATase | ECOD (1.6) |
F | CPSase_sm_chain | e1t36F2 | A: a/b three-layered sandwiches | X: The swivelling beta/beta/alpha domains | H: The swivelling beta/beta/alpha domain (From Topology) | T: The swivelling beta/beta/alpha domain | F: CPSase_sm_chain | ECOD (1.6) |
H | GATase | e1t36H1 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Class I glutamine amidotransferase-like | T: Class I glutamine amidotransferase-like | F: GATase | ECOD (1.6) |
H | CPSase_sm_chain | e1t36H2 | A: a/b three-layered sandwiches | X: The swivelling beta/beta/alpha domains | H: The swivelling beta/beta/alpha domain (From Topology) | T: The swivelling beta/beta/alpha domain | F: CPSase_sm_chain | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02142 | MGS-like domain (MGS) | MGS-like domain | This domain composes the whole protein of methylglyoxal synthetase and the domain is also found in Carbamoyl phosphate synthetase (CPS) where it forms a regulatory domain that binds to the allosteric effector ornithine. This family also includes ino ... | Domain | |
PF02786 | Carbamoyl-phosphate synthase L chain, ATP binding domain (CPSase_L_D2) | Carbamoyl-phosphate synthase L chain, ATP binding domain | Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines [2]. The c ... | Domain | |
PF02787 | Carbamoyl-phosphate synthetase large chain, oligomerisation domain (CPSase_L_D3) | Carbamoyl-phosphate synthetase large chain, oligomerisation domain | Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. | Domain | |
PF00117 | Glutamine amidotransferase class-I (GATase) | Glutamine amidotransferase class-I | - | Domain | |
PF00988 | Carbamoyl-phosphate synthase small chain, CPSase domain (CPSase_sm_chain) | Carbamoyl-phosphate synthase small chain, CPSase domain | The carbamoyl-phosphate synthase domain is in the amino terminus of protein. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both ... | Domain | |
PF07722 | Peptidase C26 (Peptidase_C26) | Peptidase C26 | These peptidases have gamma-glutamyl hydrolase activity; that is they catalyse the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to Pfam:PF00117, but contain extensions in four loops and at the C ... | Domain |