1TF0

Crystal structure of the GA module complexed with human serum albumin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1tf0b_	All alpha proteins	immunoglobulin/albumin-binding domain-like	Bacterial immunoglobulin/albumin-binding domains	GA module, an albumin-binding domain	PAB	(Finegoldia magna ATCC 29328 ) [TaxId: 334413 ],	SCOPe (2.08)
A	d1tf0a1	All alpha proteins	Serum albumin-like	Serum albumin-like	Serum albumin-like	Serum albumin	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Bacterial immunoglobulin/albumin-binding domains	8034625	3001373	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Serum albumin-like	8033047	3001552	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Serum albumin-like	8033045	3001552	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Serum albumin-like	8033044	3001552	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	GA	e1tf0B1	A: alpha bundles	X: immunoglobulin/albumin-binding domain-like	H: Bacterial immunoglobulin/albumin-binding domains (From Topology)	T: Bacterial immunoglobulin/albumin-binding domains	F: GA	ECOD (1.6)
A	Serum_albumin	e1tf0A1	A: alpha complex topology	X: Serum albumin-like (From Topology)	H: Serum albumin-like (From Topology)	T: Serum albumin-like	F: Serum_albumin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.8.40	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
A	1.10.246.10	Mainly Alpha	Orthogonal Bundle	Serum Albumin	Chain A, Domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF17573	GA-like domain (GA-like)	GA-like domain	This domain is found in bacterial cell surface proteins. It is related to the GA domain that forms a three helix bundle.	Domain
A	PF00273	Serum albumin family (Serum_albumin)	Serum albumin family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Peptostreptococcal albumin-binding protein	-	-	cellular anatomical structure extracellular region
A	Serum albumin	antioxidant activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding fatty acid binding organic acid binding lipid binding carboxylic acid binding antioxidant activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding fatty acid binding organic acid binding lipid binding carboxylic acid binding monocarboxylic acid binding protein binding exogenous protein binding cation binding transition metal ion binding copper ion binding metal ion binding toxic substance binding macrolide binding enterobactin binding protein-folding chaperone binding DNA binding nucleic acid binding identical protein binding	regulation of biological process regulation of cellular process regulation of mitochondrial depolarization negative regulation of membrane depolarization biological regulation negative regulation of biological process mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization cellular process regulation of biological quality negative regulation of mitochondrial depolarization regulation of membrane potential regulation of biological process regulation of cellular process regulation of mitochondrial depolarization negative regulation of membrane depolarization biological regulation negative regulation of biological process mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization cellular process regulation of biological quality negative regulation of mitochondrial depolarization regulation of membrane potential cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to calcium ion starvation cellular response to starvation	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm protein-containing complex blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm protein-containing complex blood microparticle intracellular organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule platelet alpha granule lumen nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR009063	Immunoglobulin/albumin-binding domain superfamily	Homologous Superfamily
B	IPR040912	Repeat of unknown function DUF5633	Repeat
B	IPR035152	GA-like domain	Domain
B	IPR019931	LPXTG cell wall anchor domain	Domain
A	IPR020857	Serum albumin, conserved site	Conserved Site
A	IPR000264	ALB/AFP/VDB	Family
A	IPR014760	Serum albumin, N-terminal	Domain
A	IPR020858	Serum albumin-like	Homologous Superfamily
A	IPR021177	Serum albumin/Alpha-fetoprotein/Afamin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P02768	thrombocytopenia pancreatitis Stevens-Johnson syndrome allergic disease hyperthyroxinemia, familial dysalbuminemic angioedema myopathy heart disease hemolytic-uremic syndrome uveitis membranous glomerulonephritis adult acute respiratory distress syndrome nephrotic syndrome glomerulonephritis kidney disease thrombocytopenia pancreatitis Stevens-Johnson syndrome allergic disease hyperthyroxinemia, familial dysalbuminemic angioedema myopathy heart disease hemolytic-uremic syndrome uveitis membranous glomerulonephritis adult acute respiratory distress syndrome nephrotic syndrome glomerulonephritis kidney disease HIV infectious disease echinococcosis hypertensive disorder interstitial nephritis Pain diabetic peripheral angiopathy melancholia urticaria congenital analbuminemia nephrosis serum sickness keloid brain disease hepatitis membranoproliferative glomerulonephritis cardiovascular disease cerebrovascular disorder endogenous depression anuria nephritis congestive heart failure aseptic meningitis azoospermia brain ischemia acute liver failure epilepsy poisoning chronic kidney disease proteinuria cirrhosis of liver asthma respiratory failure influenza coronary artery disease neurodegenerative disease autoimmune disease dense deposit disease non-alcoholic fatty liver disease bone marrow disease hepatitis C virus infection toxic epidermal necrolysis lymphatic system disease breast disease type IV hypersensitivity disease pancreatic intraductal papillary-mucinous neoplasm cancer perennial allergic rhinitis Ehlers-Danlos syndrome, arthrochalasis type peritonitis primary biliary cholangitis protein-energy malnutrition chronic obstructive pulmonary disease arthritic joint disease psoriasis inborn carbohydrate metabolic disorder gastric neoplasm atherosclerosis respiratory system disease inherited lipid metabolism disorder COVID-19 neurotic disorder obesity disorder diabetic kidney disease brain injury liver disease diabetic retinopathy hereditary diffuse gastric adenocarcinoma breast cancer tuberculosis pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia hyperglycemia peripheral neuropathy muscle tissue disease pneumonia primary membranoproliferative glomerulonephritis cholestasis esophageal varices protein-losing enteropathy hypotensive disorder inflammatory bowel disease dementia heart failure skin disease depressive disorder hepatic encephalopathy stomach disease leukopenia hepatitis B virus infection thrombotic disease lung adenocarcinoma diarrheal disease pancreas disease hereditary hyperbilirubinemia breast carcinoma type 2 diabetes mellitus malignant pancreatic neoplasm acute kidney failure pancreatic intraductal papillary-mucinous carcinoma C1 inhibitor deficiency urinary tract infection drug-induced liver injury hyperparathyroidism varicose disease metabolic acidosis peripheral vascular disease muscular disease anemia prostate carcinoma hypoglycemia extrahepatic cholestasis idiopathic membranous glomerulonephritis nephrosclerosis gastric cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.