1TJF | pdb_00001tjf

The crystal structure of the N-terminal domain of CAP indicates variable oligomerisation

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1tjfb_	All alpha proteins	N-terminal domain of adenylylcyclase associated protein, CAP	N-terminal domain of adenylylcyclase associated protein, CAP	N-terminal domain of adenylylcyclase associated protein, CAP	N-terminal domain of adenylylcyclase associated protein, CAP	(Dictyostelium discoideum ) [TaxId: 44689 ],	SCOPe (2.08)
A	d1tjfa_	All alpha proteins	N-terminal domain of adenylylcyclase associated protein, CAP	N-terminal domain of adenylylcyclase associated protein, CAP	N-terminal domain of adenylylcyclase associated protein, CAP	N-terminal domain of adenylylcyclase associated protein, CAP	(Dictyostelium discoideum ) [TaxId: 44689 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	N-terminal domain of adenylylcyclase associated protein, CAP	8041181	3001040	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	N-terminal domain of adenylylcyclase associated protein, CAP	8041181	3001040	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	CAP_N	e1tjfB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: adenylylcyclase associated protein, CAP-N (From Topology)	T: adenylylcyclase associated protein, CAP-N	F: CAP_N	ECOD (1.6)
A	CAP_N	e1tjfA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: adenylylcyclase associated protein, CAP-N (From Topology)	T: adenylylcyclase associated protein, CAP-N	F: CAP_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.25.40.330	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Adenylate cyclase-associated CAP, N-terminal domain	CATH (4.3.0)
A	1.25.40.330	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Adenylate cyclase-associated CAP, N-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21938	CAP, N-terminal domain (CAP_N)	CAP, N-terminal domain	Cyclase-associated proteins (CAPs) are highly conserved actin-binding proteins present in a wide range of organisms including yeast, fly, plants, and mammals. CAPs are multifunctional proteins that regulate actin remodelling in response to cellular s ...	Cyclase-associated proteins (CAPs) are highly conserved actin-binding proteins present in a wide range of organisms including yeast, fly, plants, and mammals. CAPs are multifunctional proteins that regulate actin remodelling in response to cellular signals [1]. They consist of an N-terminal conserved motif (Pfam:PF01213) followed by an N-terminal and C-terminal domains which are separated by a Pro-rich region. This entry represents the N-terminal domain which contains the adenylyl cyclase binding site and has an all-alpha structure consisting of six helices in a bundle with a left-handed twist and up-and-down topology [1-3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Adenylyl cyclase-associated protein	protein binding binding enzyme binding adenylate cyclase binding cytoskeletal protein binding actin binding	mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation regulation of macromolecule metabolic process mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular response to stimulus developmental process response to nutrient levels response to stimulus biological process involved in intraspecies interaction between organisms aggregation involved in sorocarp development cellular response to starvation cellular response to nutrient levels sorocarp development cellular response to stress response to stress anatomical structure development response to starvation socially cooperative development establishment or maintenance of cell polarity cell adhesion cell-cell adhesion cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization localization import into cell transport pinocytosis endocytosis establishment of localization vesicle-mediated transport vesicle organization vacuole organization contractile vacuole organization response to osmotic stress response to abiotic stimulus slug development involved in sorocarp development	cell projection cellular anatomical structure pseudopodium plasma membrane bounded cell projection cell periphery cell cortex intracellular anatomical structure cytoplasm membrane-bounded organelle organelle vesicle endosome intracellular vesicle intracellular membrane-bounded organelle cell projection cellular anatomical structure pseudopodium plasma membrane bounded cell projection cell periphery cell cortex intracellular anatomical structure cytoplasm membrane-bounded organelle organelle vesicle endosome intracellular vesicle intracellular membrane-bounded organelle macropinosome endomembrane system intracellular organelle cytoplasmic vesicle pinosome extracellular matrix external encapsulating structure membrane phagocytic vesicle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane endocytic vesicle membrane organelle membrane endocytic vesicle vacuolar membrane vacuole phagocytic cup plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017901	C-CAP/cofactor C-like domain	Domain
A, B	IPR018106	CAP, conserved site, N-terminal	Conserved Site
A, B	IPR028417	CAP, conserved site, C-terminal	Conserved Site
A, B	IPR013912	Adenylate cyclase-associated CAP, C-terminal	Domain
A, B	IPR013992	Adenylate cyclase-associated CAP, N-terminal	Conserved Site
A, B	IPR036223	Adenylate cyclase-associated CAP, C-terminal superfamily	Homologous Superfamily
A, B	IPR001837	Adenylate cyclase-associated CAP	Family
A, B	IPR006599	CARP motif	Domain
A, B	IPR016098	Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal	Homologous Superfamily
A, B	IPR036222	Adenylate cyclase-associated CAP, N-terminal domain superfamily	Homologous Superfamily
A, B	IPR053950	CAP, N-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.