Annotations: 1UQV

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1uqva1	All alpha proteins	SAM domain-like	SAM/Pointed domain	SAM (sterile alpha motif) domain	Ste50p, N-terminal domain	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
A	d1uqva2	Artifacts	Tags	Tags	Tags	N-terminal Tags	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SAM/Pointed domain	8035090	3000479	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ste50p-SAM	e1uqvA1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: Ste50p-SAM	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09235	Ste50p, sterile alpha motif (SAM_Ste50p)	Ste50p, sterile alpha motif	The fungal Ste50p SAM domain consists of five helices, which form a compact, globular fold. It is required for mediation of homodimerisation and heterodimerisation (and in some cases oligomerisation) of the protein [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	STE50 PROTEIN	enzyme regulator activity molecular function regulator activity protein kinase regulator activity kinase regulator activity protein binding binding SAM domain binding protein domain specific binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation p38MAPK cascade intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade cellular process signal transduction signal transduction involved in filamentous growth cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation p38MAPK cascade intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade cellular process signal transduction signal transduction involved in filamentous growth growth filamentous growth sexual reproduction regulation of reproductive process reproductive process positive regulation of biological process regulation of conjugation with cellular fusion response to pheromone cellular response to pheromone positive regulation of conjugation with cellular fusion positive regulation of reproductive process pheromone-dependent signal transduction involved in conjugation with cellular fusion signal transduction involved in positive regulation of conjugation with cellular fusion conjugation with cellular fusion response to pheromone triggering conjugation with cellular fusion cellular response to chemical stimulus response to chemical cell cycle regulation of cell cycle response to osmotic stress osmosensory signaling pathway via Sho1 osmosensor cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus osmosensory signaling pathway cellular response to stress response to stress response to abiotic stimulus cellular response to abiotic stimulus establishment of cell polarity establishment or maintenance of cell polarity	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000159	Ras-associating domain	Domain
A	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR015316	Ste50, sterile alpha motif	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.