2FDB | pdb_00002fdb

Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth M]	d2fdbm1	All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)	Fibroblast growth factor 8, FGF8	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth N]	d2fdbn_	All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth P]	d2fdbp1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	Fibroblast growth factor receptor, FGFR	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth R]	d2fdbr1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	Fibroblast growth factor receptor, FGFR	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth M]	SCOP2 Family	Fibroblast growth factors (FGF)	8020496	4001987	SCOP2 (2022-06-29)
A [auth M]	SCOP2 Superfamily	Cytokine	8032876	3000648	SCOP2 (2022-06-29)
C [auth N]	SCOP2B Superfamily	Cytokine	8032876	3000648	SCOP2B (2022-06-29)
B [auth P]	SCOP2 Family	I set domains	8054780	4007543	SCOP2 (2022-06-29)
B [auth P]	SCOP2 Family	I set domains	8055563	4007543	SCOP2 (2022-06-29)
B [auth P]	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8054781	3000071	SCOP2 (2022-06-29)
B [auth P]	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8055564	3000071	SCOP2 (2022-06-29)
D [auth R]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055564	3000071	SCOP2B (2022-06-29)
D [auth R]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054781	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth M]	FGF	e2fdbM1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: FGF	ECOD (1.6)
C [auth N]	FGF	e2fdbN1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: FGF	ECOD (1.6)
B [auth P]	I-set	e2fdbP2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set	ECOD (1.6)
D [auth R]	I-set	e2fdbR2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth M]	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
C [auth N]	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
B [auth P]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth R]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth M], C [auth N]	PF00167	Fibroblast growth factor (FGF)	Fibroblast growth factor	Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans [2]. Most share an internal core region of high similarity, c ...	Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans [2]. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerisation of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular [2]. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms [2].	Domain
B [auth P], D [auth R]	PF13927	Immunoglobulin domain (Ig_3)	Immunoglobulin domain	This family contains immunoglobulin-like domains.	Domain
B [auth P], D [auth R]	PF07679	Immunoglobulin I-set domain (I-set)	Immunoglobulin I-set domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth M], C [auth N]	fibroblast growth factor 8 isoform B	molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity growth factor activity signaling receptor activator activity protein binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity type 2 fibroblast growth factor receptor binding fibroblast growth factor receptor binding growth factor receptor binding molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity growth factor activity signaling receptor activator activity protein binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity type 2 fibroblast growth factor receptor binding fibroblast growth factor receptor binding growth factor receptor binding type 1 fibroblast growth factor receptor binding chemoattractant activity	response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus positive regulation of cell communication regulation of biological process regulation of signaling regulation of cellular process positive regulation of signal transduction signaling biological regulation positive regulation of biological process regulation of signal transduction positive regulation of G protein-coupled receptor signaling pathway response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus positive regulation of cell communication regulation of biological process regulation of signaling regulation of cellular process positive regulation of signal transduction signaling biological regulation positive regulation of biological process regulation of signal transduction positive regulation of G protein-coupled receptor signaling pathway cell communication positive regulation of response to stimulus regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway cellular process signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of cellular process positive regulation of signaling multicellular organismal process otic vesicle development sensory organ development tube formation embryo development epithelial tube formation multicellular organism development tube morphogenesis inner ear development otic vesicle formation anatomical structure development animal organ morphogenesis epithelial tube morphogenesis embryonic organ development developmental process embryonic organ morphogenesis ear morphogenesis epithelium development tube development ear development embryonic morphogenesis animal organ development morphogenesis of an epithelium tissue development otic vesicle morphogenesis tissue morphogenesis anatomical structure morphogenesis sensory organ morphogenesis inner ear morphogenesis anatomical structure formation involved in morphogenesis axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation cellular component organization or biogenesis system development plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons dorsal/ventral axon guidance neuron projection guidance neuron development respiratory tube development lung morphogenesis lung development respiratory system development head development forebrain development brain development pallium development central nervous system development telencephalon development corticotropin hormone secreting cell differentiation endocrine system development pituitary gland development gland development diencephalon development adenohypophysis development mesendoderm migration gastrulation epithelium migration tissue migration endoderm development cell migration involved in mesendoderm migration ameboidal-type cell migration mesendoderm development cell migration cell motility cell migration involved in gastrulation mesoderm development regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process dorsal/ventral pattern formation pattern specification process regionalization mesonephros development kidney development renal system development skeletal system development bone development genitalia development reproductive system development reproductive process sex differentiation developmental process involved in reproduction male sex differentiation male genitalia development reproductive structure development regulation of developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of stem cell proliferation cell population proliferation positive regulation of cell population proliferation positive regulation of stem cell proliferation stem cell proliferation regulation of cell population proliferation embryonic hindlimb morphogenesis limb development appendage development embryonic limb morphogenesis hindlimb morphogenesis embryonic appendage morphogenesis appendage morphogenesis limb morphogenesis positive regulation of cell division cell division regulation of cell division regulation of cell motility regulation of locomotion regulation of cell migration locomotion positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle regulation of mitotic cell cycle positive regulation of cell cycle process cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division embryo development ending in birth or egg hatching pharyngeal system development chordate embryonic development intracellular signal transduction intracellular signaling cassette MAPK cascade heart development cardiac chamber morphogenesis heart morphogenesis circulatory system development cardiac septum development cardiac septum morphogenesis cardiac chamber development outflow tract septum morphogenesis outflow tract morphogenesis branching morphogenesis of an epithelial tube angiogenesis blood vessel development blood vessel morphogenesis vasculature development branching involved in blood vessel morphogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium morphogenesis of embryonic epithelium neural plate development neural plate morphogenesis brain morphogenesis forebrain morphogenesis cell proliferation in forebrain neural precursor cell proliferation odontogenesis signal transduction involved in regulation of gene expression cell fate commitment metanephros development central nervous system neuron development central nervous system neuron differentiation forebrain generation of neurons forebrain neuron development forebrain neuron differentiation specification of animal organ identity developmental induction animal organ formation regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of animal organ morphogenesis positive regulation of animal organ morphogenesis positive regulation of multicellular organismal process regulation of animal organ formation organ induction neuroepithelial cell differentiation columnar/cuboidal epithelial cell differentiation epithelial cell differentiation mesonephric epithelium development kidney epithelium development nephron morphogenesis nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development ureteric bud morphogenesis branching involved in ureteric bud morphogenesis renal tubule development nephron development nephron epithelium development ureteric bud development kidney morphogenesis mesonephric tubule morphogenesis mesonephric tubule development renal tubule morphogenesis endocardial cushion morphogenesis mesenchyme development endocardial cushion development cardiac epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation mesenchyme morphogenesis epithelial to mesenchymal transition endocardial cushion formation mesenchymal cell differentiation mesodermal cell migration regulation of odontogenesis of dentin-containing tooth regulation of odontogenesis odontogenesis of dentin-containing tooth embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry determination of left/right symmetry specification of symmetry determination of heart left/right asymmetry left/right pattern formation developmental growth growth organ growth positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade thyroid gland development aorta morphogenesis artery development aorta development artery morphogenesis motor neuron axon guidance gonad development development of primary sexual characteristics neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of neuron apoptotic process thyroid-stimulating hormone-secreting cell differentiation neuroendocrine cell differentiation glandular epithelial cell differentiation subpallium development blood vessel remodeling tissue remodeling response to fibroblast growth factor cellular response to growth factor stimulus cell surface receptor signaling pathway response to endogenous stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus fibroblast growth factor receptor signaling pathway response to growth factor cellular response to fibroblast growth factor stimulus enzyme-linked receptor protein signaling pathway forebrain dorsal/ventral pattern formation forebrain regionalization regulation of growth regulation of developmental growth positive regulation of organ growth positive regulation of growth regulation of organ growth positive regulation of developmental growth embryonic cranial skeleton morphogenesis embryonic neurocranium morphogenesis cranial skeletal system development embryonic skeletal system development skeletal system morphogenesis embryonic skeletal system morphogenesis larynx development larynx morphogenesis regulation of muscle tissue development striated muscle tissue development muscle structure development negative regulation of muscle organ development regulation of cardiac muscle tissue development muscle tissue development muscle organ development cardiac muscle tissue development negative regulation of developmental process regulation of striated muscle tissue development negative regulation of muscle tissue development negative regulation of cardiac muscle tissue development regulation of muscle organ development negative regulation of multicellular organismal process negative regulation of striated muscle tissue development response to oxidative stress response to stress branching involved in salivary gland morphogenesis salivary gland development gland morphogenesis salivary gland morphogenesis exocrine system development dopaminergic neuron differentiation regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of peptidyl-tyrosine phosphorylation primary metabolic process macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process peptidyl-tyrosine phosphorylation anterior/posterior pattern specification rostrocaudal neural tube patterning neural tube development neural tube patterning midbrain-hindbrain boundary development	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane intracellular anatomical structure cytoplasm extracellular region extracellular space
B [auth P], D [auth R]	Fibroblast growth factor receptor 2	molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity collagen receptor activity protein tyrosine kinase collagen receptor activity GPI-linked ephrin receptor activity protein-hormone receptor activity insulin receptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding platelet-derived growth factor beta-receptor activity platelet-derived growth factor receptor activity stem cell factor receptor activity brain-derived neurotrophic factor receptor activity neurotrophin receptor activity hepatocyte growth factor receptor activity macrophage colony-stimulating factor receptor activity platelet-derived growth factor alpha-receptor activity identical protein binding protein binding protein homodimerization activity protein dimerization activity vascular endothelial growth factor receptor activity histone H2AXY142 kinase activity histone modifying activity histone kinase activity histone H2AX kinase activity histone H3Y41 kinase activity histone H3 kinase activity placental growth factor receptor activity fibroblast growth factor binding growth factor binding insulin-like growth factor receptor activity boss receptor activity epidermal growth factor receptor activity fibroblast growth factor receptor activity heparin binding glycosaminoglycan binding sulfur compound binding	developmental process tissue morphogenesis anatomical structure morphogenesis epithelium development epidermis morphogenesis epidermis development anatomical structure development morphogenesis of an epithelium tissue development regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation biological regulation developmental process tissue morphogenesis anatomical structure morphogenesis epithelium development epidermis morphogenesis epidermis development anatomical structure development morphogenesis of an epithelium tissue development regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation biological regulation cellular process regulation of osteoblast proliferation osteoblast proliferation multicellular organismal process ossification bone mineralization animal organ development biomineral tissue development lateral sprouting from an epithelium morphogenesis of a branching structure morphogenesis of a branching epithelium mammary gland morphogenesis mammary gland development mammary gland bud formation gland development mammary gland bud morphogenesis embryo development multicellular organism development tube morphogenesis gland morphogenesis morphogenesis of an epithelial bud animal organ morphogenesis epithelial tube morphogenesis morphogenesis of an epithelial fold morphogenesis of embryonic epithelium tube development embryonic morphogenesis mammary gland duct morphogenesis mammary gland epithelium development anatomical structure formation involved in morphogenesis reproductive system development prostate gland development reproductive process urogenital system development developmental process involved in reproduction prostate gland morphogenesis reproductive structure development system development apoptotic process cell death programmed cell death cellular response to stimulus response to lipid response to stimulus response to oxygen-containing compound cellular response to oxygen-containing compound response to retinoic acid cellular response to chemical stimulus cellular response to retinoic acid response to chemical cellular response to lipid chordate embryonic development labyrinthine layer development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development placenta development branching involved in labyrinthine layer morphogenesis in utero embryonic development embryonic placenta morphogenesis labyrinthine layer morphogenesis molting cycle process hair cycle skin development skin epidermis development hair follicle development molting cycle hair cycle process hair follicle morphogenesis cellular developmental process epithelial cell differentiation prostate glandular acinus development cell differentiation epithelial cell differentiation involved in prostate gland development squamous basal epithelial stem cell differentiation involved in prostate gland acinus development glandular epithelial cell differentiation stem cell differentiation columnar/cuboidal epithelial cell differentiation axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cellular component organization or biogenesis plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons neuron development regulation of phospholipase activity regulation of molecular function positive regulation of molecular function positive regulation of hydrolase activity positive regulation of phospholipase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity positive regulation of lipase activity heart development cardiac chamber morphogenesis heart morphogenesis circulatory system development cardiac septum development cardiac septum morphogenesis cardiac chamber development outflow tract septum morphogenesis outflow tract morphogenesis mesenchymal cell proliferation involved in lung development respiratory tube development mesenchymal cell proliferation lung development respiratory system development odontogenesis cell fate commitment skeletal system development skeletal system morphogenesis negative regulation of cell population proliferation regulation of keratinocyte proliferation negative regulation of biological process negative regulation of keratinocyte proliferation negative regulation of cellular process regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation keratinocyte proliferation developmental growth growth organ growth bone growth endochondral bone growth bone development RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process response to fibroblast growth factor cellular response to growth factor stimulus negative regulation of apoptotic process in bone marrow cell signaling regulation of apoptotic process in bone marrow cell regulation of programmed cell death cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell signal transduction enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway negative regulation of programmed cell death response to endogenous stimulus apoptotic process in bone marrow cell regulation of apoptotic process negative regulation of apoptotic process fibroblast growth factor receptor signaling pathway response to growth factor cellular response to fibroblast growth factor stimulus positive regulation of biological process cell cycle regulation of cell cycle positive regulation of cell cycle positive regulation of cellular process regulation of osteoblast differentiation regulation of developmental process regulation of cell differentiation osteoblast differentiation lung lobe morphogenesis lung lobe development lung morphogenesis positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling branching morphogenesis of a nerve ear morphogenesis embryonic organ morphogenesis ear development sensory organ development sensory organ morphogenesis inner ear development inner ear morphogenesis positive regulation of cell population proliferation epithelial cell proliferation involved in lung morphogenesis regulation of epithelial cell proliferation involved in lung morphogenesis positive regulation of epithelial cell proliferation involved in lung morphogenesis positive regulation of epithelial cell proliferation lung epithelium development neuroblast proliferation forebrain development forebrain neuroblast division ventricular zone neuroblast division cell proliferation in forebrain head development forebrain generation of neurons neuroblast division brain development central nervous system development forebrain ventricular zone progenitor cell division cell division neural precursor cell proliferation positive regulation of mesenchymal cell proliferation regulation of mesenchymal cell proliferation mammary gland specification specification of animal organ identity pattern specification process animal organ formation fibroblast growth factor receptor signaling pathway involved in mammary gland specification regionalization mammary gland formation positive regulation of cell proliferation in bone marrow fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow cell proliferation in bone marrow regulation of cell proliferation in bone marrow formation of primary germ layer mesodermal cell differentiation mesoderm morphogenesis gastrulation mesoderm formation mesoderm development regulation of morphogenesis of a branching structure regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway embryonic pattern specification exocrine system development lacrimal gland development branching morphogenesis of an epithelial tube axis elongation bud elongation involved in lung branching branch elongation of an epithelium developmental growth involved in morphogenesis epithelial tube branching involved in lung morphogenesis biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin lung alveolus development otic vesicle development tube formation epithelial tube formation otic vesicle formation otic vesicle morphogenesis limb development appendage development limb bud formation appendage morphogenesis limb morphogenesis response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to stress response to hypoxia response to stress response to oxygen levels response to abiotic stimulus regulation of growth regulation of cardiac muscle tissue growth cardiac muscle cell proliferation striated muscle tissue development positive regulation of developmental process positive regulation of cardiac muscle cell proliferation regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation cardiac muscle tissue growth muscle tissue development positive regulation of developmental growth positive regulation of heart growth striated muscle cell proliferation heart growth regulation of multicellular organismal development regulation of developmental growth cardiac muscle tissue development positive regulation of organ growth positive regulation of growth positive regulation of cardiac muscle tissue growth positive regulation of multicellular organismal process smooth muscle cell differentiation regulation of smooth muscle cell differentiation muscle cell differentiation muscle structure development regulation of muscle cell differentiation ventricular septum development ventricular septum morphogenesis membranous septum morphogenesis cardiac ventricle development cell-cell signaling positive regulation of cell division regulation of cell division protein phosphorylation protein autophosphorylation phosphorylation macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition prostate gland epithelium morphogenesis prostate gland morphogenetic growth prostate gland growth branching involved in prostate gland morphogenesis prostate epithelial cord elongation fibroblast growth factor receptor signaling pathway involved in hemopoiesis hemopoiesis ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue development muscle organ development muscle tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis muscle organ morphogenesis positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process bone morphogenesis orbitofrontal cortex development limbic system development midbrain development pyramidal neuron development central nervous system neuron development central nervous system neuron differentiation forebrain neuron development forebrain neuron differentiation pyramidal neuron differentiation blood vessel morphogenesis angiogenesis vasculature development blood vessel development lung-associated mesenchyme development response to transforming growth factor beta cellular response to transforming growth factor beta stimulus salivary gland development epithelial cell proliferation involved in salivary gland morphogenesis salivary gland morphogenesis embryonic cranial skeleton morphogenesis cranial skeletal system development embryonic skeletal system development embryonic skeletal system morphogenesis smoothened signaling pathway regulation of smoothened signaling pathway digestive system development digestive tract development regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation vascular associated smooth muscle cell proliferation response to alcohol response to ethanol peptidyl-tyrosine modification peptidyl-amino acid modification peptidyl-tyrosine phosphorylation ureteric bud development mesonephric epithelium development kidney epithelium development mesonephros development renal system development kidney development mesonephric tubule development mesenchymal cell differentiation involved in lung development prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis prostate glandular acinus morphogenesis fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development embryonic digestive tract morphogenesis digestive tract morphogenesis embryonic digestive tract development branching involved in salivary gland morphogenesis post-embryonic development branch elongation involved in salivary gland morphogenesis	protein-containing complex receptor complex cell surface cellular anatomical structure cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm protein-containing complex receptor complex cell surface cellular anatomical structure cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm intracellular membrane-bounded organelle vesicle extracellular region synapse cell junction excitatory synapse Golgi apparatus endomembrane system cell cortex nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth M], C [auth N]	IPR008996	Cytokine IL1/FGF	Homologous Superfamily
A [auth M], C [auth N]	IPR002209	Fibroblast growth factor family	Family
B [auth P], D [auth R]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B [auth P], D [auth R]	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
B [auth P], D [auth R]	IPR000719	Protein kinase domain	Domain
B [auth P], D [auth R]	IPR003599	Immunoglobulin domain subtype	Domain
B [auth P], D [auth R]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B [auth P], D [auth R]	IPR007110	Immunoglobulin-like domain	Domain
B [auth P], D [auth R]	IPR017441	Protein kinase, ATP binding site	Binding Site
B [auth P], D [auth R]	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
B [auth P], D [auth R]	IPR016248	Fibroblast growth factor receptor family	Family
B [auth P], D [auth R]	IPR008266	Tyrosine-protein kinase, active site	Active Site
B [auth P], D [auth R]	IPR003598	Immunoglobulin subtype 2	Domain
B [auth P], D [auth R]	IPR013098	Immunoglobulin I-set	Domain
B [auth P], D [auth R]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B [auth P], D [auth R]	IPR050122	Receptor Tyrosine Kinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth M], C [auth N]	Pharos: P55075	Kallmann syndrome hypogonadotropic hypogonadism 6 with or without anosmia DiGeorge syndrome cleft palate 22q11 Deletion Syndrome velocardiofacial syndrome Klinefelter syndrome holoprosencephaly lobar holoprosencephaly hypogonadotropic hypogonadism medulloblastoma alobar holoprosencephaly cleft lip hypogonadotropic hypogonadism 1 with or without anosmia semilobar holoprosencephaly Kallmann syndrome hypogonadotropic hypogonadism 6 with or without anosmia DiGeorge syndrome cleft palate 22q11 Deletion Syndrome velocardiofacial syndrome Klinefelter syndrome holoprosencephaly lobar holoprosencephaly hypogonadotropic hypogonadism medulloblastoma alobar holoprosencephaly cleft lip hypogonadotropic hypogonadism 1 with or without anosmia semilobar holoprosencephaly atrial fibrillation hypogonadotropic hypogonadism 2 with or without anosmia
B [auth P], D [auth R]	Pharos: P21802	LADD syndrome craniosynostosis Pfeiffer syndrome Beare-Stevenson cutis gyrata syndrome Jackson-Weiss syndrome Saethre-Chotzen syndrome Crouzon syndrome cholangiocarcinoma Cowden disease breast carcinoma acrocephalosyndactyly Plagiocephaly, Nonsynostotic FGFR2-related bent bone dysplasia breast cancer cancer LADD syndrome craniosynostosis Pfeiffer syndrome Beare-Stevenson cutis gyrata syndrome Jackson-Weiss syndrome Saethre-Chotzen syndrome Crouzon syndrome cholangiocarcinoma Cowden disease breast carcinoma acrocephalosyndactyly Plagiocephaly, Nonsynostotic FGFR2-related bent bone dysplasia breast cancer cancer cleft palate ankylosis apert syndrome familial scaphocephaly syndrome, McGillivray type intellectual disability hereditary diffuse gastric adenocarcinoma developmental coordination disorder endometrial cancer cirrhosis of liver spina bifida Antley-Bixler syndrome Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis endometrial carcinoma gastric cancer intrahepatic cholangiocarcinoma non-small cell lung carcinoma lung adenocarcinoma Pfeiffer syndrome type 3 malignant ependymoma biliary tract cancer gastric carcinoma head and neck cancer medulloblastoma schizophrenia hydrolethalus syndrome skin disease cutaneous lupus erythematosus osteogenesis imperfecta Lhermitte-Duclos disease ovarian serous adenocarcinoma lung benign neoplasm atypical teratoid rhabdoid tumor Pfeiffer syndrome type 1 endometrium adenocarcinoma benign neoplasm of stomach familial scaphocephaly syndrome malignant glioma bipolar disorder polydactyly gastric neoplasm PTEN hamartoma tumor syndrome head and neck carcinoma Sjogren syndrome idiopathic pulmonary fibrosis adenoma interstitial lung disease nevus, epidermal depressive disorder stomach carcinoma in situ osteosarcoma Down syndrome pancreatic intraductal papillary-mucinous neoplasm trigonocephaly lung cancer Bannayan-Riley-Ruvalcaba syndrome Pfeiffer syndrome type 2 endometrium carcinoma in situ malignant colon neoplasm bile duct cancer pilocytic astrocytoma preeclampsia prostate cancer glioblastoma choanal atresia cleft lip head and neck neoplasm hydrocephalus adrenal cortex carcinoma squamous cell lung carcinoma oligodendroglioma subependymal giant cell astrocytoma large cell medulloblastoma ovarian cancer tethered spinal cord syndrome arthrogryposis ulcerative colitis lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.