2J4G

Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with n-butyl- thiazoline inhibitor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2j4ga1	All alpha proteins	Hyaluronidase domain-like	Hyaluronidase post-catalytic domain-like	Hyaluronidase post-catalytic domain-like	Glucosaminidase GH84 post-catalytic domain	(Bacteroides thetaiotaomicron VPI-5482 ) [TaxId: 226186 ],	SCOPe (2.08)
A	d2j4ga2	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	(Trans)glycosidases	alpha-D-glucuronidase/Hyaluronidase catalytic domain	Glucosaminidase GH84, catalytic domain	(Bacteroides thetaiotaomicron VPI-5482 ) [TaxId: 226186 ],	SCOPe (2.08)
A	d2j4ga3	Alpha and beta proteins (a+b)	Zincin-like	beta-N-acetylhexosaminidase-like domain	Hyaluronidase N-terminal domain-like	Glucosaminidase GH84, N-terminal domain	(Bacteroides thetaiotaomicron VPI-5482 ) [TaxId: 226186 ],	SCOPe (2.08)
B	d2j4gb1	All alpha proteins	Hyaluronidase domain-like	Hyaluronidase post-catalytic domain-like	Hyaluronidase post-catalytic domain-like	Glucosaminidase GH84 post-catalytic domain	(Bacteroides thetaiotaomicron VPI-5482 ) [TaxId: 226186 ],	SCOPe (2.08)
B	d2j4gb2	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	(Trans)glycosidases	alpha-D-glucuronidase/Hyaluronidase catalytic domain	Glucosaminidase GH84, catalytic domain	(Bacteroides thetaiotaomicron VPI-5482 ) [TaxId: 226186 ],	SCOPe (2.08)
B	d2j4gb3	Alpha and beta proteins (a+b)	Zincin-like	beta-N-acetylhexosaminidase-like domain	Hyaluronidase N-terminal domain-like	Glucosaminidase GH84, N-terminal domain	(Bacteroides thetaiotaomicron VPI-5482 ) [TaxId: 226186 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Hyaluronidase post-catalytic domain-like	8037810	3001475	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	(Trans)glycosidases	8037813	3000313	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	beta-N-acetylhexosaminidase-like domain	8037815	3000192	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Hyaluronidase post-catalytic domain-like	8037810	3001475	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	(Trans)glycosidases	8037813	3000313	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	beta-N-acetylhexosaminidase-like domain	8037815	3000192	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glyco_hydro_84_helical	e2j4gA1	A: alpha bundles	X: Hyaluronidase domain-like	H: Hyaluronidase post-catalytic domain-like (From Topology)	T: Hyaluronidase post-catalytic domain-like	F: Glyco_hydro_84_helical	ECOD (1.6)
A	NAGidase	e2j4gA2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: NAGidase	ECOD (1.6)
A	Glyco_hydro_20b	e2j4gA3	A: mixed a+b and a/b	X: Zincin-like	H: beta-N-acetylhexosaminidase-like domain (From Topology)	T: beta-N-acetylhexosaminidase-like domain	F: Glyco_hydro_20b	ECOD (1.6)
B	Glyco_hydro_84_helical	e2j4gB1	A: alpha bundles	X: Hyaluronidase domain-like	H: Hyaluronidase post-catalytic domain-like (From Topology)	T: Hyaluronidase post-catalytic domain-like	F: Glyco_hydro_84_helical	ECOD (1.6)
B	NAGidase	e2j4gB2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: NAGidase	ECOD (1.6)
B	Glyco_hydro_20b	e2j4gB3	A: mixed a+b and a/b	X: Zincin-like	H: beta-N-acetylhexosaminidase-like domain (From Topology)	T: beta-N-acetylhexosaminidase-like domain	F: Glyco_hydro_20b	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.379.10	Alpha Beta	2-Layer Sandwich	Chitobiase	domain 2	CATH (4.3.0)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A	1.20.58.460	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	3.30.379.10	Alpha Beta	2-Layer Sandwich	Chitobiase	domain 2	CATH (4.3.0)
B	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
B	1.20.58.460	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21809	Bacterial GH84, post-catalytic domain (Glyco_hydro_84_hel)	Bacterial GH84, post-catalytic domain	This is a helical domain found after the catalytic domain of enzymes from the Glycoside hydrolase family 84 from Bacteroides spp. and certain pathogenic Clostridia spp [1-5].	Domain
A, B	PF18344	Carbohydrate binding module family 32 (CBM32)	Carbohydrate binding module family 32	This domain is found in GH84C present in Clostridium perfringens. GH84C is a beta-N-acetylglucosaminidase. This domain is a family 32 carbohydrate binding module (CBM) which preferentially recognizes the non-reducing terminus of N-acetyllactosamine [ ...	This domain is found in GH84C present in Clostridium perfringens. GH84C is a beta-N-acetylglucosaminidase. This domain is a family 32 carbohydrate binding module (CBM) which preferentially recognizes the non-reducing terminus of N-acetyllactosamine [1].	Domain
A, B	PF07555	beta-N-acetylglucosaminidase (NAGidase)	beta-N-acetylglucosaminidase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	HYALURONOGLUCOSAMINIDASE	hydrolase activity, acting on glycosyl bonds hexosaminidase activity beta-N-acetylhexosaminidase activity beta-N-acetylglucosaminidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity catalytic activity, acting on a protein identical protein binding protein binding binding	carbohydrate metabolic process primary metabolic process metabolic process cellular process macromolecule modification protein deglycosylation carbohydrate derivative metabolic process protein metabolic process macromolecule metabolic process protein modification process glycoprotein metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR051822	Glycosyl Hydrolase Family 84	Family
A, B	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B	IPR029018	Beta-hexosaminidase-like, domain 2	Homologous Superfamily
A, B	IPR049478	O-GlcNAcase BT_4395-like, post-catalytic domain	Domain
A, B	IPR011496	Beta-N-acetylglucosaminidase, catalytic domain	Domain
A, B	IPR048162	O-GlcNAcase BT_4395-like	Family
A, B	IPR013780	Glycosyl hydrolase, all-beta	Homologous Superfamily
A, B	IPR015882	Beta-hexosaminidase, bacterial type, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.