Annotations: 2J7N

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Two-barrel nucleic acid polymerases	8055682	3001330	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Two-barrel nucleic acid polymerases	8055683	3001330	SCOP2B (2022-06-29)
A	SCOP2 Family	RdRP-like	8046930	4005374	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Two-barrel nucleic acid polymerases	8055682	3001330	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Two-barrel nucleic acid polymerases	8055683	3001330	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	RdRP_3rd	e2j7nB2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RdRP_3rd	ECOD (1.6)
B	RdRP_2nd	e2j7nB3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RdRP_2nd	ECOD (1.6)
B	RdRP_4th	e2j7nB4	A: alpha complex topology	X: RNAi polymerase helical domain (From Topology)	H: RNAi polymerase helical domain (From Topology)	T: RNAi polymerase helical domain	F: RdRP_4th	ECOD (1.6)
B	RdRP_1st	e2j7nB1	A: a+b complex topology	X: RNAi polymerase N-terminal domain (From Topology)	H: RNAi polymerase N-terminal domain (From Topology)	T: RNAi polymerase N-terminal domain	F: RdRP_1st	ECOD (1.6)
A	RdRP_3rd	e2j7nA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RdRP_3rd	ECOD (1.6)
A	RdRP_2nd	e2j7nA2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RdRP_2nd	ECOD (1.6)
A	RdRP_4th	e2j7nA4	A: alpha complex topology	X: RNAi polymerase helical domain (From Topology)	H: RNAi polymerase helical domain (From Topology)	T: RNAi polymerase helical domain	F: RdRP_4th	ECOD (1.6)
A	RdRP_1st	e2j7nA1	A: a+b complex topology	X: RNAi polymerase N-terminal domain (From Topology)	H: RNAi polymerase N-terminal domain (From Topology)	T: RNAi polymerase N-terminal domain	F: RdRP_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.8.790	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
A	1.10.8.790	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	RNA-DEPENDENT RNA POLYMERASE	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups RNA binding nucleic acid binding guanyl nucleotide binding GTP binding guanyl ribonucleotide binding cation binding metal ion binding identical protein binding protein binding	regulation of cellular process negative regulation of biological process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of cellular process negative regulation of biological process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process siRNA processing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus RNA-directed RNA polymerase complex nuclear protein-containing complex nuclear RNA-directed RNA polymerase complex intracellular membrane-bounded organelle transferase complex transferase complex, transferring phosphorus-containing groups intracellular organelle cellular anatomical structure organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus RNA-directed RNA polymerase complex nuclear protein-containing complex nuclear RNA-directed RNA polymerase complex intracellular membrane-bounded organelle transferase complex transferase complex, transferring phosphorus-containing groups intracellular organelle cellular anatomical structure organelle RNA polymerase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR057596	RDRP, core domain	Domain
A, B	IPR007855	RNA-dependent RNA polymerase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.