2JD4 | pdb_00002jd4

Mouse laminin alpha1 chain, domains LG4-5

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2jd4a1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d2jd4b1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Laminin_G_1	e2jd4A3	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Laminin_G_1	ECOD (1.6)
B	Laminin_G_1	e2jd4B2	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Laminin_G_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
B	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02210	Laminin G domain (Laminin_G_2)	Laminin G domain	This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.	Domain
A, B	PF00054	Laminin G domain (Laminin_G_1)	Laminin G domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	LAMININ SUBUNIT ALPHA-1	glycosphingolipid binding binding sphingolipid binding lipid binding glycolipid binding carbohydrate derivative binding protein binding signaling receptor binding structural molecule activity extracellular matrix structural constituent	developmental process anatomical structure development tissue development tissue morphogenesis anatomical structure morphogenesis epithelium development morphogenesis of an epithelium morphogenesis of an epithelial sheet regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process developmental process anatomical structure development tissue development tissue morphogenesis anatomical structure morphogenesis epithelium development morphogenesis of an epithelium morphogenesis of an epithelial sheet regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation muscle cell differentiation positive regulation of muscle cell differentiation muscle structure development positive regulation of developmental process regulation of muscle cell differentiation positive regulation of cell differentiation cell differentiation cellular process positive regulation of cellular process multicellular organismal process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development sensory system development system development branching morphogenesis of an epithelial tube respiratory tube development tube morphogenesis lung morphogenesis lung development respiratory system development animal organ morphogenesis epithelial tube morphogenesis tube development morphogenesis of a branching structure epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium polarized epithelial cell differentiation establishment of monopolar cell polarity establishment or maintenance of monopolar cell polarity establishment or maintenance of cell polarity epithelial cell differentiation morphogenesis of a polarized epithelium establishment or maintenance of apical/basal cell polarity establishment or maintenance of bipolar cell polarity establishment of epithelial cell apical/basal polarity establishment of cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment of apical/basal cell polarity establishment of epithelial cell polarity regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion cell adhesion positive regulation of cell adhesion regulation of cell adhesion cellular response to stimulus positive regulation of cell communication regulation of integrin-mediated signaling pathway positive regulation of signal transduction response to stimulus signaling regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of integrin-mediated signaling pathway signal transduction regulation of signaling integrin-mediated signaling pathway cell surface receptor signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process regulation of embryonic development regulation of multicellular organismal development embryo development regulation of multicellular organismal process regulation of cellular component organization extracellular matrix organization cellular component organization cellular component organization or biogenesis regulation of basement membrane organization regulation of extracellular matrix organization extracellular structure organization external encapsulating structure organization basement membrane organization gland development branching involved in salivary gland morphogenesis salivary gland development gland morphogenesis salivary gland morphogenesis exocrine system development blood vessel morphogenesis retina vasculature development in camera-type eye retina vasculature morphogenesis in camera-type eye vasculature development circulatory system development retinal blood vessel morphogenesis blood vessel development plasma membrane bounded cell projection organization cell projection organization cell development neuron projection development nervous system development generation of neurons neurogenesis neuron differentiation neuron development	laminin complex basement membrane cell periphery extracellular matrix protein-containing complex cellular anatomical structure external encapsulating structure laminin-1 complex membrane cell-cell junction anchoring junction cell junction extracellular region protein complex involved in cell-matrix adhesion laminin complex basement membrane cell periphery extracellular matrix protein-containing complex cellular anatomical structure external encapsulating structure laminin-1 complex membrane cell-cell junction anchoring junction cell junction extracellular region protein complex involved in cell-matrix adhesion protein complex involved in cell adhesion extracellular space laminin-3 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008211	Laminin, N-terminal	Domain
A, B	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B	IPR002049	Laminin-type EGF domain	Domain
A, B	IPR010307	Laminin domain II	Domain
A, B	IPR000742	EGF-like domain	Domain
A, B	IPR001791	Laminin G domain	Domain
A, B	IPR056863	Laminin/attractin/netrin-like, EGF domain	Domain
A, B	IPR009254	Laminin alpha, domain I	Domain
A, B	IPR050440	Laminin/Netrin Extracellular Matrix	Family
A, B	IPR000034	Laminin IV	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.