2LFG | pdb_00002lfg

Solution structure of the human prolactin receptor ecd domain d2

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Fibronectin type III	8055515	3002063	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	fn3_6	e2lfgA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3_6	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Prolactin receptor	protein binding binding cytokine binding kinase binding enzyme binding protein kinase binding lipid binding amide binding peptide hormone binding hormone binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity protein binding binding cytokine binding kinase binding enzyme binding protein kinase binding lipid binding amide binding peptide hormone binding hormone binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity prolactin receptor activity cation binding ion binding metal ion binding small molecule binding	regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling response to cytokine cytokine-mediated signaling pathway cell communication response to peptide regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus signal transduction developmental process mammary gland epithelial cell differentiation epithelium development cellular developmental process mammary gland development gland development animal organ development tissue development epithelial cell differentiation mammary gland epithelium development cell differentiation anatomical structure development biosynthetic process steroid metabolic process lipid biosynthetic process primary metabolic process metabolic process steroid biosynthetic process lipid metabolic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death multicellular organism development multicellular organismal process multi-multicellular organism process reproductive process female pregnancy embryo implantation multi-organism reproductive process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of biological process positive regulation of cellular process response to granulocyte macrophage colony-stimulating factor cellular response to granulocyte macrophage colony-stimulating factor stimulus cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT homeostatic process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of metabolic process biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus regulation of body fluid levels secretion transport establishment of localization body fluid secretion localization lactation regulation of biological quality positive regulation of B cell proliferation regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation regulation of B cell proliferation lymphocyte proliferation regulation of B cell activation positive regulation of leukocyte activation positive regulation of mononuclear cell proliferation regulation of immune system process positive regulation of immune system process regulation of lymphocyte proliferation regulation of leukocyte proliferation B cell activation cell activation positive regulation of lymphocyte proliferation B cell proliferation positive regulation of B cell activation mononuclear cell proliferation immune system process positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation positive regulation of cell communication positive regulation of signal transduction positive regulation of phosphorylation regulation of catalytic activity positive regulation of receptor signaling pathway via STAT regulation of signal transduction regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process regulation of receptor signaling pathway via JAK-STAT positive regulation of macromolecule metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of response to stimulus activation of protein kinase activity macromolecule modification regulation of phosphorus metabolic process macromolecule metabolic process regulation of receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of receptor signaling pathway via JAK-STAT positive regulation of response to stimulus positive regulation of molecular function positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity activation of Janus kinase activity regulation of signaling positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of cell communication regulation of phosphorylation peptidyl-tyrosine phosphorylation positive regulation of signaling reproductive system development developmental growth prostate gland development growth urogenital system development organ growth developmental process involved in reproduction reproductive structure development prostate gland growth system development cell surface receptor protein tyrosine kinase signaling pathway cellular component biogenesis cellular component assembly activation of transmembrane receptor protein tyrosine kinase activity cellular component organization protein-containing complex assembly cellular component organization or biogenesis enzyme-linked receptor protein signaling pathway protein-containing complex organization mammary gland lobule development mammary gland alveolus development regulation of multicellular organismal development regulation of developmental process regulation of cell differentiation regulation of epithelial cell differentiation	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex receptor complex extracellular region membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex receptor complex extracellular region membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle cytoplasm endosome lumen vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015152	Growth hormone/erythropoietin receptor, ligand binding	Domain
A	IPR050379	Type I Cytokine Receptor	Family
A	IPR003961	Fibronectin type III	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR003528	Long hematopoietin receptor, single chain, conserved site	Conserved Site
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P16471	multiple fibroadenoma of the breast endometriosis acquired hyperprolactinemia sarcomatoid carcinoma carcinoma hyperprolactinemia Mammary Neoplasms, Experimental medulloblastoma osteosarcoma undifferentiated carcinoma malignant glioma mammary neoplasms, animal pituitary cancer breast carcinoma invasive ductal breast carcinoma multiple fibroadenoma of the breast endometriosis acquired hyperprolactinemia sarcomatoid carcinoma carcinoma hyperprolactinemia Mammary Neoplasms, Experimental medulloblastoma osteosarcoma undifferentiated carcinoma malignant glioma mammary neoplasms, animal pituitary cancer breast carcinoma invasive ductal breast carcinoma malignant pancreatic neoplasm nasopharyngeal carcinoma psoriasis ulcerative colitis autism breast fibroadenoma ductal breast carcinoma in situ familial hyperprolactinemia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.