Annotations: 2PJR

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
G [auth F]	d2pjr.2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Tandem AAA-ATPase domain	DEXX box DNA helicase	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)
E [auth A]	d2pjr.1	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Tandem AAA-ATPase domain	DEXX box DNA helicase	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)
H [auth G]	d2pjr.2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Tandem AAA-ATPase domain	DEXX box DNA helicase	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)
F [auth B]	d2pjr.1	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Tandem AAA-ATPase domain	DEXX box DNA helicase	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
G [auth F]	SCOP2B Superfamily	RecA-like P-loop NTPases	8044310	3002019	SCOP2B (2022-06-29)
E [auth A]	SCOP2B Superfamily	RecA-like P-loop NTPases	8044310	3002019	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
G [auth F]	UvrD-helicase	e2pjrF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: UvrD-helicase	ECOD (1.6)
E [auth A]	UvrD-helicase	e2pjrA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: UvrD-helicase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
G [auth F]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
G [auth F]	1.10.10.160	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
G [auth F]	1.10.486.10	Mainly Alpha	Orthogonal Bundle	PCRA	domain 4	CATH (4.3.0)
E [auth A]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
E [auth A]	1.10.10.160	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
E [auth A]	1.10.486.10	Mainly Alpha	Orthogonal Bundle	PCRA	domain 4	CATH (4.3.0)
H [auth G]	3.30.160.800	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain		CATH (4.3.0)
F [auth B]	3.30.160.800	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain		CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D]	DNA (5'-D(TPTPTPTP*T)-3')	-	-	-
C [auth H]	DNA (5'-D(GPC)-3')	-	-	-
D [auth I]	DNA (5'-D(APCPTPGP*C)-3')	-	-	-
E [auth A], G [auth F]	PROTEIN (HELICASE PCRA)	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity nucleic acid conformation isomerase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity 3'-5' DNA helicase activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA macromolecular conformation isomerase activity	nucleobase-containing compound metabolic process DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus DNA recombination cellular response to stress DNA damage response response to stress nucleobase-containing compound metabolic process DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus DNA recombination cellular response to stress DNA damage response response to stress recombinational repair DNA repair response to radiation response to abiotic stimulus	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex DNA helicase complex
F [auth B], H [auth G]	PROTEIN (HELICASE PCRA)	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity nucleic acid conformation isomerase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity 3'-5' DNA helicase activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA macromolecular conformation isomerase activity	nucleobase-containing compound metabolic process DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus DNA recombination cellular response to stress DNA damage response response to stress nucleobase-containing compound metabolic process DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus DNA recombination cellular response to stress DNA damage response response to stress recombinational repair DNA repair response to radiation response to abiotic stimulus	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex DNA helicase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A], G [auth F]	IPR014017	UvrD-like helicase, C-terminal	Domain
E [auth A], G [auth F]	IPR000212	UvrD-like helicase	Family
E [auth A], G [auth F]	IPR014016	UvrD-like helicase, ATP-binding domain	Domain
E [auth A], G [auth F]	IPR005751	ATP-dependent DNA helicase PcrA	Family
E [auth A], G [auth F]	IPR013986	DExx box DNA helicase domain superfamily	Homologous Superfamily
E [auth A], G [auth F]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
F [auth B], H [auth G]	IPR014017	UvrD-like helicase, C-terminal	Domain
F [auth B], H [auth G]	IPR000212	UvrD-like helicase	Family
F [auth B], H [auth G]	IPR014016	UvrD-like helicase, ATP-binding domain	Domain
F [auth B], H [auth G]	IPR005751	ATP-dependent DNA helicase PcrA	Family
F [auth B], H [auth G]	IPR013986	DExx box DNA helicase domain superfamily	Homologous Superfamily
F [auth B], H [auth G]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.