2QKQ | pdb_00002qkq

Structure of the SAM Domain of Human Ephrin Type-B Receptor 4

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2qkqb_	All alpha proteins	SAM domain-like	SAM/Pointed domain	SAM (sterile alpha motif) domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2qkqa_	All alpha proteins	SAM domain-like	SAM/Pointed domain	SAM (sterile alpha motif) domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	SAM/Pointed domain	8079639	3000479	SCOP2B (2022-06-29)
A	SCOP2 Family	SAM (sterile alpha motif) domain	8079638	4001022	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SAM/Pointed domain	8079639	3000479	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	SAM_1	e2qkqB1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: SAM_1	ECOD (1.6)
A	SAM_1	e2qkqA1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: SAM_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
A	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Ephrin type-B receptor 4	molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ephrin receptor activity	developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular process signal transduction enzyme-linked receptor protein signaling pathway ephrin receptor signaling pathway cell migration involved in sprouting angiogenesis endothelial cell migration sprouting angiogenesis blood vessel endothelial cell migration cell migration cell motility heart development heart morphogenesis animal organ development animal organ morphogenesis cell adhesion	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane protein-containing complex receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B	IPR001426	Tyrosine-protein kinase, receptor class V, conserved site	Conserved Site
A, B	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B	IPR001090	Ephrin, ligand binding domain	Domain
A, B	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A, B	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR050449	Ephrin receptor tyrosine kinases	Family
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like	Domain
A, B	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR034290	Ephrin type-B receptor 4, ligand binding domain	Domain
A, B	IPR037636	EPH-B4, SAM domain	Domain
A, B	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A, B	IPR003961	Fibronectin type III	Domain
A, B	IPR016257	Ephrin receptor type-A /type-B	Family
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR027936	Ephrin, transmembrane domain	Domain
A, B	IPR001660	Sterile alpha motif domain	Domain
A, B	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P54760	hydrops fetalis, nonimmune, and/or atrial septal defect, susceptibility to breast carcinoma ovarian cancer Philadelphia Chromosome Positive Chronic Myelocytic Leukemia tetralogy of fallot amyotrophic lateral sclerosis breast cancer juvenile dermatomyositis medulloblastoma pancreatic intraductal papillary-mucinous carcinoma atypical teratoid rhabdoid tumor Crohn disease hypertensive disorder lung carcinoma metastatic melanoma hydrops fetalis, nonimmune, and/or atrial septal defect, susceptibility to breast carcinoma ovarian cancer Philadelphia Chromosome Positive Chronic Myelocytic Leukemia tetralogy of fallot amyotrophic lateral sclerosis breast cancer juvenile dermatomyositis medulloblastoma pancreatic intraductal papillary-mucinous carcinoma atypical teratoid rhabdoid tumor Crohn disease hypertensive disorder lung carcinoma metastatic melanoma Parkinson disease psoriasis gastric adenocarcinoma inflammatory bowel disease lymphatic system disease