Annotations: 2QNR

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Septin	e2qnrA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Septin	ECOD (1.6)
B	Septin	e2qnrB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Septin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Septin-2	enzyme regulator activity molecular function regulator activity catalytic activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding enzyme regulator activity molecular function regulator activity catalytic activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cell adhesion molecule binding cadherin binding protein binding molecular adaptor activity pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides identical protein binding	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation smoothened signaling pathway cell communication cellular process signal transduction developmental process spermatogenesis sexual reproduction cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation smoothened signaling pathway cell communication cellular process signal transduction developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular developmental process cell differentiation cytoskeleton-dependent cytokinesis cytokinesis cell division cell cycle cell cycle process protein localization localization cellular localization cellular macromolecule localization macromolecule localization organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular component organization or biogenesis cilium organization cell projection assembly regulation of localization regulation of protein localization regulation of cellular localization regulation of transport transport secretion export from cell regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport regulation of secretion regulation of secretion by cell secretion by cell exocytosis regulation of exocytosis import into cell nitrogen compound transport carboxylic acid transmembrane transport amino acid transmembrane transport L-amino acid transport L-glutamate import regulation of L-glutamate import across plasma membrane regulation of amino acid transport regulation of amino acid transmembrane transport L-glutamate import across plasma membrane organic acid transmembrane transport organic anion transport carboxylic acid transport import across plasma membrane organic acid transport transmembrane transport amino acid transport amine transport acidic amino acid transport regulation of amino acid import across plasma membrane regulation of transmembrane transport regulation of organic acid transport dicarboxylic acid transport L-alpha-amino acid transmembrane transport amino acid import across plasma membrane regulation of amine transport L-glutamate transmembrane transport	midbody cellular anatomical structure membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium intracellular membraneless organelle cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection cytoskeleton midbody cellular anatomical structure membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium intracellular membraneless organelle cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection cytoskeleton organelle membraneless organelle cytoplasm cell cortex septin ring cell periphery septin cytoskeleton ciliary transition zone non-motile cilium 9+0 non-motile cilium neuron projection photoreceptor cell cilium photoreceptor connecting cilium extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle actin cytoskeleton cell surface cell division site plasma membrane membrane protein-containing complex septin complex cleavage furrow plasma membrane region nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen microtubule cytoskeleton ciliary membrane bounding membrane of organelle organelle membrane cell projection membrane intercellular bridge chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome 9+2 motile cilium sperm annulus sperm flagellum motile cilium spindle transport vesicle synapse intracellular vesicle endomembrane system presynapse cytoplasmic vesicle synaptic vesicle cell junction secretory vesicle exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR030379	Septin-type guanine nucleotide-binding (G) domain	Domain
A, B	IPR008113	Septin 2	Family
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR016491	Septin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q15019	methylmalonic acidemia pilocytic astrocytoma primitive neuroectodermal tumor psoriasis Alzheimer disease B-cell chronic lymphocytic leukemia Down syndrome large cell medulloblastoma malignant glioma Nonorganic psychosis ovarian cancer plasma cell myeloma progressive supranuclear palsy astrocytic tumor congestive heart failure methylmalonic acidemia pilocytic astrocytoma primitive neuroectodermal tumor psoriasis Alzheimer disease B-cell chronic lymphocytic leukemia Down syndrome large cell medulloblastoma malignant glioma Nonorganic psychosis ovarian cancer plasma cell myeloma progressive supranuclear palsy astrocytic tumor congestive heart failure glioblastoma lung adenocarcinoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma primary cutaneous T-cell non-Hodgkin lymphoma prostate carcinoma rheumatoid arthritis atypical teratoid rhabdoid tumor diabetes mellitus hereditary spastic paraplegia malignant ependymoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.