2W6O
Crystal structure of Biotin carboxylase from E. coli in complex with 4-Amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B [auth C] | SCOP2B Superfamily | PreATP-grasp domain | 8034649 | 3001680 | SCOP2B (2022-06-29) |
B [auth C] | SCOP2B Superfamily | Rudiment single hybrid motif | 8034648 | 3001910 | SCOP2B (2022-06-29) |
B [auth C] | SCOP2B Superfamily | Glutathione synthetase ATP-binding domain-like | 8034650 | 3000094 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Glutathione synthetase ATP-binding domain-like | 8034650 | 3000094 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | PreATP-grasp domain | 8034649 | 3001680 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Rudiment single hybrid motif | 8034648 | 3001910 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B [auth C] | ATP-grasp | e2w6oC7 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: ATP-grasp | F: ATP-grasp | ECOD (1.6) |
B [auth C] | Biotin_carb_C | e2w6oC6 | A: a+b complex topology | X: alpha/beta-Hammerhead/Barrel-sandwich hybrid | H: alpha/beta-Hammerhead/Barrel-sandwich hybrid | T: CO dehydrogenase molybdoprotein N-domain-like | F: Biotin_carb_C | ECOD (1.6) |
B [auth C] | Biotin_carb_N | e2w6oC3 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: PreATP-grasp domain | F: Biotin_carb_N | ECOD (1.6) |
A | ATP-grasp | e2w6oA1 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: ATP-grasp | F: ATP-grasp | ECOD (1.6) |
A | Biotin_carb_C | e2w6oA2 | A: a+b complex topology | X: alpha/beta-Hammerhead/Barrel-sandwich hybrid | H: alpha/beta-Hammerhead/Barrel-sandwich hybrid | T: CO dehydrogenase molybdoprotein N-domain-like | F: Biotin_carb_C | ECOD (1.6) |
A | Biotin_carb_N | e2w6oA3 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: PreATP-grasp domain | F: Biotin_carb_N | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B [auth C] | 3.40.50.20 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | CATH (4.3.0) | |
B [auth C] | 3.30.470.20 | Alpha Beta | 2-Layer Sandwich | D-amino Acid Aminotransferase | Chain A, domain 1 | CATH (4.3.0) |
B [auth C] | 3.30.1490.20 | Alpha Beta | 2-Layer Sandwich | Dna Ligase | domain 1 | CATH (4.3.0) |
A | 3.40.50.20 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | CATH (4.3.0) | |
A | 3.30.470.20 | Alpha Beta | 2-Layer Sandwich | D-amino Acid Aminotransferase | Chain A, domain 1 | CATH (4.3.0) |
A | 3.30.1490.20 | Alpha Beta | 2-Layer Sandwich | Dna Ligase | domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, B [auth C] | PF02786 | Carbamoyl-phosphate synthase L chain, ATP binding domain (CPSase_L_D2) | Carbamoyl-phosphate synthase L chain, ATP binding domain | Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines [2]. The c ... | Domain |
A, B [auth C] | PF02785 | Biotin carboxylase C-terminal domain (Biotin_carb_C) | Biotin carboxylase C-terminal domain | Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyses the first committed step in fatty acid synthesis in animals, plants and bacteria. Most of the active site residues reported in reference [1] are i ... | Domain |
A, B [auth C] | PF00289 | Biotin carboxylase, N-terminal domain (Biotin_carb_N) | Biotin carboxylase, N-terminal domain | This domain is structurally related to the PreATP-grasp domain. The family contains the N-terminus of biotin carboxylase enzymes [1,3], and propionyl-CoA carboxylase A chain [2]. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A, B [auth C] | IPR005481 | Biotin carboxylase-like, N-terminal domain | Domain |
A, B [auth C] | IPR011761 | ATP-grasp fold | Domain |
A, B [auth C] | IPR011764 | Biotin carboxylation domain | Domain |
A, B [auth C] | IPR051602 | Acetyl-CoA Carboxylase Biotin Carboxylase Component | Family |
A, B [auth C] | IPR013815 | ATP-grasp fold, subdomain 1 | Homologous Superfamily |
A, B [auth C] | IPR004549 | Acetyl-CoA carboxylase, biotin carboxylase | Family |
A, B [auth C] | IPR005482 | Biotin carboxylase, C-terminal | Domain |
A, B [auth C] | IPR005479 | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | Domain |
A, B [auth C] | IPR016185 | Pre-ATP-grasp domain superfamily | Homologous Superfamily |
A, B [auth C] | IPR011054 | Rudiment single hybrid motif | Homologous Superfamily |