Annotations: 2WAU

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Duffy_binding	e2wauA2	A: alpha bundles	X: Duffy-binding-like domain, N-terminal subdomain (From Topology)	H: Duffy-binding-like domain, N-terminal subdomain (From Topology)	T: Duffy-binding-like domain, N-terminal subdomain	F: Duffy_binding	ECOD (1.6)
A	PTZ00176	e2wauA1	A: alpha bundles	X: Duffy-binding-like domain, C-terminal subdomain (From Topology)	H: Duffy-binding-like domain, C-terminal subdomain (From Topology)	T: Duffy-binding-like domain, C-terminal subdomain	F: PTZ00176	ECOD (1.6)
B	Duffy_binding	e2wauB2	A: alpha bundles	X: Duffy-binding-like domain, N-terminal subdomain (From Topology)	H: Duffy-binding-like domain, N-terminal subdomain (From Topology)	T: Duffy-binding-like domain, N-terminal subdomain	F: Duffy_binding	ECOD (1.6)
B	PTZ00176	e2wauB1	A: alpha bundles	X: Duffy-binding-like domain, C-terminal subdomain (From Topology)	H: Duffy-binding-like domain, C-terminal subdomain (From Topology)	T: Duffy-binding-like domain, C-terminal subdomain	F: PTZ00176	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1310.20	Mainly Alpha	Up-down Bundle	5 helical Cullin repeat like	Duffy-antigen binding domain	CATH (4.3.0)
A	1.20.58.830	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.1310.20	Mainly Alpha	Up-down Bundle	5 helical Cullin repeat like	Duffy-antigen binding domain	CATH (4.3.0)
B	1.20.58.830	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05424	Duffy binding domain (Duffy_binding)	Duffy binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ERYTHROCYTE MEMBRANE PROTEIN 1 (PFEMP1)	cell adhesion molecule binding protein binding binding host cell surface binding host cell surface receptor binding	symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host erythrocyte aggregation modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction adhesion of symbiont to host cell adhesion of symbiont to host adhesion of symbiont to microvasculature cell adhesion cell-cell adhesion cellular process response to host defenses symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host erythrocyte aggregation modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction adhesion of symbiont to host cell adhesion of symbiont to host adhesion of symbiont to microvasculature cell adhesion cell-cell adhesion cellular process response to host defenses response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus evasion of host immune response response to host immune response response to host response to external biotic stimulus antigenic variation	infected host cell surface knob host cellular component host intracellular part cellular anatomical structure host cell cytoplasm host cell part host intracellular region host cell cytoplasm part membrane host cell plasma membrane host cell membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004258	Duffy-binding-like domain	Domain
A, B	IPR042202	Duffy-antigen binding superfamily	Homologous Superfamily
A, B	IPR032761	Plasmodium falciparum erythrocyte membrane protein 1, N-terminal	Domain
A, B	IPR008602	Duffy-antigen binding domain	Domain
A, B	IPR044932	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment superfamily	Homologous Superfamily
A, B	IPR029211	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.