Annotations: 2WBS

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2wbsa_	Small proteins	beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	automated matches	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	zf-C2H2_18	e2wbsA2	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: zf-C2H2_18	ECOD (1.6)
A	zf-C2H2_17	e2wbsA3	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: zf-C2H2_17	ECOD (1.6)
A	zf-C2H2_13	e2wbsA1	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: zf-C2H2_13	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.160.60	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Classic Zinc Finger	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00096	Zinc finger, C2H2 type (zf-C2H2)	Zinc finger, C2H2 type	The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, an ...	The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	KRUEPPEL-LIKE FACTOR 4	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding histone deacetylase binding protein binding enzyme binding transcription factor binding transcription coregulator binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding histone deacetylase binding protein binding enzyme binding transcription factor binding transcription coregulator binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding ion binding metal ion binding small molecule binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity protein-macromolecule adaptor activity molecular adaptor activity chromatin DNA binding beta-catenin binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process positive regulation of cellular process response to tumor cell response to stimulus defense response response to stress defense response to tumor cell response to biotic stimulus developmental process multicellular organismal process sensory organ development post-embryonic camera-type eye development eye development animal organ development visual system development multicellular organism development camera-type eye development anatomical structure development post-embryonic development sensory system development system development tissue morphogenesis anatomical structure morphogenesis epithelium development epidermis morphogenesis epidermis development morphogenesis of an epithelium tissue development cellular response to stimulus cell surface receptor signaling pathway signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway regulation of developmental process regulation of blastocyst development chordate embryonic development embryo development in utero embryonic development embryo development ending in birth or egg hatching blastocyst development establishment of skin barrier skin development skin epidermis development regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process macromolecule metabolic process negative regulation of leukocyte adhesion to arterial endothelial cell regulation of cell adhesion negative regulation of biological process regulation of leukocyte adhesion to vascular endothelial cell leukocyte cell-cell adhesion negative regulation of cell adhesion negative regulation of leukocyte adhesion to vascular endothelial cell regulation of leukocyte adhesion to arterial endothelial cell cell adhesion cell-cell adhesion negative regulation of leukocyte cell-cell adhesion leukocyte adhesion to vascular endothelial cell negative regulation of cell-cell adhesion leukocyte adhesion to arterial endothelial cell regulation of leukocyte cell-cell adhesion negative regulation of cellular process regulation of cell-cell adhesion response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound response to retinoic acid cellular response to chemical stimulus cellular response to retinoic acid response to chemical cellular response to lipid positive regulation of protein metabolic process positive regulation of hemoglobin biosynthetic process regulation of primary metabolic process protein metabolic process hemoglobin metabolic process hemoglobin biosynthetic process regulation of protein metabolic process primary metabolic process regulation of hemoglobin biosynthetic process RNA metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of cell-cell adhesion involved in gastrulation heterotypic cell-cell adhesion regulation of heterotypic cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules cell-cell adhesion involved in gastrulation embryonic morphogenesis gastrulation negative regulation of heterotypic cell-cell adhesion positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of miRNA metabolic process regulation of RNA metabolic process miRNA transcription regulation of miRNA metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of miRNA transcription response to peptide cellular response to peptide chemokine (C-X-C motif) ligand 2 production negative regulation of chemokine production regulation of chemokine (C-X-C motif) ligand 2 production regulation of cytokine production cytokine production regulation of multicellular organismal process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cytokine production regulation of chemokine production negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process chemokine production negative regulation of multicellular organismal process negative regulation of chemokine (C-X-C motif) ligand 2 production maintenance of cell number stem cell population maintenance negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion fat cell differentiation cellular developmental process cell differentiation cell migration involved in sprouting angiogenesis regulation of blood vessel endothelial cell migration endothelial cell migration angiogenesis negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration tube morphogenesis blood vessel endothelial cell migration regulation of endothelial cell migration blood vessel development blood vessel morphogenesis tube development regulation of cell migration involved in sprouting angiogenesis sprouting angiogenesis vasculature development circulatory system development anatomical structure formation involved in morphogenesis negative regulation of cell migration involved in sprouting angiogenesis negative regulation of interleukin-8 production interleukin-8 production regulation of interleukin-8 production somatic stem cell population maintenance epidermal cell differentiation epithelial cell differentiation positive regulation of organelle organization regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization telomere organization cellular component organization cellular component organization or biogenesis positive regulation of telomere maintenance chromosome organization regulation of chromosome organization DNA metabolic process regulation of organelle organization positive regulation of chromosome organization telomere maintenance organelle organization positive regulation of DNA metabolic process regulation of DNA metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of RNA metabolic process positive regulation of transcription by RNA polymerase II negative regulation of extrinsic apoptotic signaling pathway in absence of ligand signal transduction in absence of ligand negative regulation of signaling regulation of signal transduction regulation of programmed cell death negative regulation of cell communication extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand regulation of signaling negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway negative regulation of intracellular signal transduction negative regulation of canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction negative regulation of cell population proliferation cell population proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation cellular response to oxidative stress cellular response to chemical stress cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to stress response to laminar fluid shear stress cellular response to laminar fluid shear stress response to fluid shear stress cellular response to fluid shear stress hemopoiesis cell development post-embryonic hemopoiesis cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus response to growth factor regulation of cell cycle phase transition negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process negative regulation of G1/S transition of mitotic cell cycle negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition response to cytokine regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus regulation of sprouting angiogenesis regulation of vasculature development positive regulation of developmental process positive regulation of sprouting angiogenesis regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process glandular epithelial cell differentiation columnar/cuboidal epithelial cell differentiation negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis negative regulation of vasculature development cellular response to nitrogen compound response to ketone response to cycloheximide response to alcohol cellular response to organic cyclic compound response to nitrogen compound cellular response to alcohol cellular response to cycloheximide cellular response to ketone response to organic cyclic compound regulation of neuron projection development regulation of response to external stimulus cell projection organization regulation of cellular response to stress neuron projection development regeneration response to axon injury neuron projection regeneration regulation of response to wounding neurogenesis neuron differentiation axon regeneration regulation of response to stress response to wounding regulation of axon regeneration plasma membrane bounded cell projection organization regulation of cell projection organization response to external stimulus nervous system development axon development generation of neurons neuron development regulation of neuron projection regeneration regulation of plasma membrane bounded cell projection organization response to leukemia inhibitory factor cellular response to cytokine stimulus cellular response to leukemia inhibitory factor regulation of cell differentiation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton euchromatin chromatin chromosome
B [auth F]	5'-D(GPAPGPGPCPGP*CP)-3'	-	-	-
C [auth G]	5'-D(GPCPGPCPCPTP*CP)-3'	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013087	Zinc finger C2H2-type	Domain
A	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.