2WZP | pdb_00002wzp

Structures of Lactococcal Phage p2 Baseplate Shed Light on a Novel Mechanism of Host Attachment and Activation in Siphoviridae

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
L	d2wzpl1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
L	d2wzpl2	Artifacts	Tags	Tags	Tags	N-terminal Tags	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
K	d2wzpk1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
K	d2wzpk2	Artifacts	Tags	Tags	Tags	N-terminal Tags	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
J	d2wzpj1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
J	d2wzpj2	Artifacts	Tags	Tags	Tags	N-terminal Tags	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
F	d2wzpf1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
F	d2wzpf2	Artifacts	Tags	Tags	Tags	N-terminal Tags	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
E	d2wzpe1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
E	d2wzpe2	Artifacts	Tags	Tags	Tags	N-terminal Tags	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
D	d2wzpd1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
D	d2wzpd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	LLAMA (Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
I	SCOP2B Superfamily	Bacteriophage trimeric proteins domain	8036194	3000915	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Phage fibre proteins	8036192	3000351	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Virus attachment protein globular domain	8036189	3001376	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Bacteriophage trimeric proteins domain	8036194	3000915	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Virus attachment protein globular domain	8036189	3001376	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Phage fibre proteins	8036192	3000351	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Bacteriophage trimeric proteins domain	8036194	3000915	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Phage fibre proteins	8036192	3000351	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Virus attachment protein globular domain	8036189	3001376	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Virus attachment protein globular domain	8036189	3001376	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Bacteriophage trimeric proteins domain	8036194	3000915	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Phage fibre proteins	8036192	3000351	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Virus attachment protein globular domain	8036189	3001376	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Phage fibre proteins	8036192	3000351	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Bacteriophage trimeric proteins domain	8036194	3000915	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Phage fibre proteins	8036192	3000351	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Bacteriophage trimeric proteins domain	8036194	3000915	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Virus attachment protein globular domain	8036189	3001376	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
O [auth R]	Caudo_bapla16_4th	e2wzpR3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Phage tail proteins	F: Caudo_bapla16_4th	ECOD (1.6)
O [auth R]	Caudo_bapla16_1st	e2wzpR1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Phage tail proteins	F: Caudo_bapla16_1st	ECOD (1.6)
O [auth R]	Caudo_bapla16_2nd	e2wzpR2	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: Caudo_bapla16_2nd	ECOD (1.6)
O [auth R]	Caudo_bapla16_3rd	e2wzpR4	A: a+b complex topology	X: C-terminal insertion domain in phage tail proteins (From Topology)	H: C-terminal insertion domain in phage tail proteins (From Topology)	T: C-terminal insertion domain in phage tail proteins	F: Caudo_bapla16_3rd	ECOD (1.6)
N [auth Q]	Baseplate	e2wzpQ1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Phage tail proteins	F: Baseplate	ECOD (1.6)
N [auth Q]	EUF07673	e2wzpQ2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in distal tail protein (Dit)-like proteins (From Topology)	T: Jelly-roll domain in distal tail protein (Dit)-like proteins	F: EUF07673	ECOD (1.6)
M [auth P]	Baseplate	e2wzpP1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Phage tail proteins	F: Baseplate	ECOD (1.6)
M [auth P]	EUF07673	e2wzpP2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in distal tail protein (Dit)-like proteins (From Topology)	T: Jelly-roll domain in distal tail protein (Dit)-like proteins	F: EUF07673	ECOD (1.6)
L	V-set_8	e2wzpL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
K	V-set_8	e2wzpK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
J	V-set_8	e2wzpJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
F	V-set_8	e2wzpF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
E	V-set_8	e2wzpE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
D	V-set_8	e2wzpD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
I	Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	e2wzpI3	A: beta sandwiches	X: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	H: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	T: Lactophage receptor-binding protein N-terminal domain-like	F: Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	ECOD (1.6)
I	Caudo_bapla_RBP_3rd	e2wzpI2	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Caudo_bapla_RBP_3rd	ECOD (1.6)
I	Caudo_bapla_RBP_1st_1	e2wzpI1	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_1st_1	ECOD (1.6)
I	Caudo_bapla_RBP_like	e2wzpI4	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_like	ECOD (1.6)
H	Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	e2wzpH3	A: beta sandwiches	X: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	H: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	T: Lactophage receptor-binding protein N-terminal domain-like	F: Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	ECOD (1.6)
H	Caudo_bapla_RBP_3rd	e2wzpH2	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Caudo_bapla_RBP_3rd	ECOD (1.6)
H	Caudo_bapla_RBP_1st_1	e2wzpH1	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_1st_1	ECOD (1.6)
H	Caudo_bapla_RBP_like	e2wzpH4	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_like	ECOD (1.6)
G	Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	e2wzpG3	A: beta sandwiches	X: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	H: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	T: Lactophage receptor-binding protein N-terminal domain-like	F: Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	ECOD (1.6)
G	Caudo_bapla_RBP_3rd	e2wzpG2	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Caudo_bapla_RBP_3rd	ECOD (1.6)
G	Caudo_bapla_RBP_1st_1	e2wzpG1	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_1st_1	ECOD (1.6)
G	Caudo_bapla_RBP_like	e2wzpG4	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_like	ECOD (1.6)
C	Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	e2wzpC3	A: beta sandwiches	X: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	H: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	T: Lactophage receptor-binding protein N-terminal domain-like	F: Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	ECOD (1.6)
C	Caudo_bapla_RBP_3rd	e2wzpC2	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Caudo_bapla_RBP_3rd	ECOD (1.6)
C	Caudo_bapla_RBP_1st_1	e2wzpC1	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_1st_1	ECOD (1.6)
C	Caudo_bapla_RBP_like	e2wzpC4	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_like	ECOD (1.6)
B	Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	e2wzpB3	A: beta sandwiches	X: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	H: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	T: Lactophage receptor-binding protein N-terminal domain-like	F: Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	ECOD (1.6)
B	Caudo_bapla_RBP_3rd	e2wzpB2	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Caudo_bapla_RBP_3rd	ECOD (1.6)
B	Caudo_bapla_RBP_1st_1	e2wzpB1	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_1st_1	ECOD (1.6)
B	Caudo_bapla_RBP_like	e2wzpB4	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_like	ECOD (1.6)
A	Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	e2wzpA3	A: beta sandwiches	X: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	H: Lactophage receptor-binding protein N-terminal domain-like (From Topology)	T: Lactophage receptor-binding protein N-terminal domain-like	F: Caudo_bapla_RBP_1st_1,Caudo_bapla_RBP_1st	ECOD (1.6)
A	Caudo_bapla_RBP_3rd	e2wzpA2	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Caudo_bapla_RBP_3rd	ECOD (1.6)
A	Caudo_bapla_RBP_1st_1	e2wzpA1	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_1st_1	ECOD (1.6)
A	Caudo_bapla_RBP_like	e2wzpA4	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: Caudo_bapla_RBP_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
O [auth R]	2.30.300.20	Mainly Beta	Roll	Phage tail proteins - horseshoe like beta roll fold	Phage tail base-plate attachment protein, domain D1/D2	CATH (4.3.0)
O [auth R]	3.55.50.50	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold	Phage tail base-plate attachment protein, domain D4	CATH (4.3.0)
O [auth R]	3.30.1920.20	Alpha Beta	2-Layer Sandwich	Phage tail proteins - 2 layer sandwich fold	Phage tail base-plate attachment protein, domain D3	CATH (4.3.0)
N [auth Q]	2.40.30.210	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
N [auth Q]	6.20.370.40	Special	Other non-globular	Rhinovirus 14, subunit 4		CATH (4.3.0)
N [auth Q]	2.60.120.880	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
N [auth Q]	2.10.25.60	Mainly Beta	Ribbon	Laminin		CATH (4.3.0)
M [auth P]	2.40.30.210	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
M [auth P]	6.20.370.40	Special	Other non-globular	Rhinovirus 14, subunit 4		CATH (4.3.0)
M [auth P]	2.60.120.880	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
M [auth P]	2.10.25.60	Mainly Beta	Ribbon	Laminin		CATH (4.3.0)
L	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
K	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
J	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
I	2.60.520.10	Mainly Beta	Sandwich	Triple-stranded beta-helix	Phage fibre proteins	CATH (4.3.0)
I	2.60.40.1830	Mainly Beta	Sandwich	Immunoglobulin-like	Phage tail base-plate Siphoviridae RBP, head domain	CATH (4.3.0)
H	2.60.520.10	Mainly Beta	Sandwich	Triple-stranded beta-helix	Phage fibre proteins	CATH (4.3.0)
H	2.60.40.1830	Mainly Beta	Sandwich	Immunoglobulin-like	Phage tail base-plate Siphoviridae RBP, head domain	CATH (4.3.0)
G	2.60.520.10	Mainly Beta	Sandwich	Triple-stranded beta-helix	Phage fibre proteins	CATH (4.3.0)
G	2.60.40.1830	Mainly Beta	Sandwich	Immunoglobulin-like	Phage tail base-plate Siphoviridae RBP, head domain	CATH (4.3.0)
C	2.60.520.10	Mainly Beta	Sandwich	Triple-stranded beta-helix	Phage fibre proteins	CATH (4.3.0)
C	2.60.40.1830	Mainly Beta	Sandwich	Immunoglobulin-like	Phage tail base-plate Siphoviridae RBP, head domain	CATH (4.3.0)
B	2.60.520.10	Mainly Beta	Sandwich	Triple-stranded beta-helix	Phage fibre proteins	CATH (4.3.0)
B	2.60.40.1830	Mainly Beta	Sandwich	Immunoglobulin-like	Phage tail base-plate Siphoviridae RBP, head domain	CATH (4.3.0)
A	2.60.520.10	Mainly Beta	Sandwich	Triple-stranded beta-helix	Phage fibre proteins	CATH (4.3.0)
A	2.60.40.1830	Mainly Beta	Sandwich	Immunoglobulin-like	Phage tail base-plate Siphoviridae RBP, head domain	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
D, E, F, J, K D, E, F, J, K, L	Llama heavy chain VH domain H5	VH	Lama glama (llama)	IGHV3S301, IGHJ401	V-DOMAIN VH	IG	(VH)	IMGT (202547-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
D, E, F, J, K D, E, F, J, K, L	Heavy Chain	IGHV1	-	putative receptor binding protein	SAbDab (2025-12-05)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
O [auth R]	PF16792	Phage tail base-plate attachment protein N-terminal barrel domain (Caud_bapl16_1st)	Phage tail base-plate attachment protein N-terminal barrel domain	Caudo_bapla16 is a family of ORF16 tail-phage P2-like proteins that forms part of the base-plate at the tip of the phage tail. The whole base-plate complex is involved in host recognition and attachment, and consists of several proteins derived from ...	Caudo_bapla16 is a family of ORF16 tail-phage P2-like proteins that forms part of the base-plate at the tip of the phage tail. The whole base-plate complex is involved in host recognition and attachment, and consists of several proteins derived from consecutive open-reading-frames. This entry represents the N-terminal RIFT barrel domain.	Domain
O [auth R]	PF20955	Phage tail base-plate attachment protein C-terminal barrel domain (Caud_bapl16_4th)	Phage tail base-plate attachment protein C-terminal barrel domain	Caudo_bapla16 is a family of ORF16 tail-phage P2-like proteins that forms part of the base-plate at the tip of the phage tail. The whole base-plate complex is involved in host recognition and attachment, and consists of several proteins derived from ...	Caudo_bapla16 is a family of ORF16 tail-phage P2-like proteins that forms part of the base-plate at the tip of the phage tail. The whole base-plate complex is involved in host recognition and attachment, and consists of several proteins derived from consecutive open-reading-frames. This entry represents the C-terminal RIFT barrel domain [1].	Domain
O [auth R]	PF20954	Phage tail base-plate attachment protein N0 domain (Caud_bapl16_2nd)	Phage tail base-plate attachment protein N0 domain	Caudo_bapla16 is a family of ORF16 tail-phage P2-like proteins that forms part of the base-plate at the tip of the phage tail. The whole base-plate complex is involved in host recognition and attachment, and consists of several proteins derived from ...	Caudo_bapla16 is a family of ORF16 tail-phage P2-like proteins that forms part of the base-plate at the tip of the phage tail. The whole base-plate complex is involved in host recognition and attachment, and consists of several proteins derived from consecutive open-reading-frames. This entry represents the N0 domain [1].	Domain
O [auth R]	PF20953	Phage tail base-plate attachment protein C-terminal insertion domain (Caud_bapl16_3rd)	Phage tail base-plate attachment protein C-terminal insertion domain	Caudo_bapla16 is a family of ORF16 tail-phage P2-like proteins that forms part of the base-plate at the tip of the phage tail. The whole base-plate complex is involved in host recognition and attachment, and consists of several proteins derived from ...	Caudo_bapla16 is a family of ORF16 tail-phage P2-like proteins that forms part of the base-plate at the tip of the phage tail. The whole base-plate complex is involved in host recognition and attachment, and consists of several proteins derived from consecutive open-reading-frames. This entry represents the insertion domain found within the C-terminal RIFT barrel domain [1].	Domain
M [auth P], N [auth Q]	PF16774	Distal tail protein, N-terminal domain (Dit_N)	Distal tail protein, N-terminal domain	This domain is found at the N-terminal end of Distal tail protein from Lactococcus phage p2 (Dit) and similar sequences predominantly found in Siphoviridae and bacterial prophages from Lactobacillales. Dit has a structural role and forms the distal ...	This domain is found at the N-terminal end of Distal tail protein from Lactococcus phage p2 (Dit) and similar sequences predominantly found in Siphoviridae and bacterial prophages from Lactobacillales. Dit has a structural role and forms the distal part of the tail. It is organised into two domains, a ring domain that shows a split (this entry) barrel-like fold and a C-terminal galectin domain. Consecutive Dit N-terminal domains form a tight ring with two layers of beta-strands. This ring frames a channel sufficiently large for dsDNA passage [1,2]. This protein is involved in the process of viral genome ejection through the host cell envelope using a long flexible tail mechanism. The Distal tail protein forms the distal part of the tail structure and plays a role in DNA ejection. It self-associates as two rings that are arranged back to back, creating a central channel through which the DNA is ejected into the host cell. Additionally, it interacts with the receptor binding protein, facilitating the attachment of the phage to the host cell. At the structural level, the Distal tail protein is composed of homohexameric subunits.	Domain
M [auth P], N [auth Q]	PF21766	Dit, C-terminal domain (Dit_C)	Dit, C-terminal domain	This domain is found at the C-terminal end of Distal tail protein from Lactococcus phage p2 (Dit or Gp15) and similar proteins predominantly found in virus. Dit self-associates as two rings organised back to back, with a central channel allowing DNA ...	This domain is found at the C-terminal end of Distal tail protein from Lactococcus phage p2 (Dit or Gp15) and similar proteins predominantly found in virus. Dit self-associates as two rings organised back to back, with a central channel allowing DNA ejection through the viral tail. This domain is located at the ring periphery and display a galectin fold [1,2].	Domain
A, B, C, G, H A, B, C, G, H, I	PF21564	Lactococcus phage p2, Receptor binding protein, neck domain (Caudo_bapla_RBP_neck)	Lactococcus phage p2, Receptor binding protein, neck domain	This domain is found centrally located in Receptor binding protein from Lactococcus phage p2 (RBP, also known as Gp18) and similar proteins from closely related lactococcal phages. RBP shows three domains: the N-terminal shoulder domain (Pfam:PF20747 ...	This domain is found centrally located in Receptor binding protein from Lactococcus phage p2 (RBP, also known as Gp18) and similar proteins from closely related lactococcal phages. RBP shows three domains: the N-terminal shoulder domain (Pfam:PF20747), which is attached to the phage, the neck domain (this entry) and the C -terminal receptor-recognition head domain (Pfam:PF08931). The central domain folds into four beta-strands, which interlace with the beta-strands of two other subunits to form an equilateral triangular prism around the three-fold axis of a triple-stranded beta-helix [1,2].	Domain
A, B, C, G, H A, B, C, G, H, I	PF20747	Lactophage receptor-binding protein N-terminal shoulder domain (Caudo_bapla_N)	Lactophage receptor-binding protein N-terminal shoulder domain	Caudo_bapla_RBP is a family of proteins expressed from ORF18 of the Lactococcus P2-like phage. This is one of three protein domain, shoulder, neck, and head, that form the phage tail base-plate. This entry represents the shoulder domain. This domain ...	Caudo_bapla_RBP is a family of proteins expressed from ORF18 of the Lactococcus P2-like phage. This is one of three protein domain, shoulder, neck, and head, that form the phage tail base-plate. This entry represents the shoulder domain. This domain contains a beta sandwich fold [1].	Domain
A, B, C, G, H A, B, C, G, H, I	PF08931	Lactophage receptor-binding protein C-terminal head domain (Caudo_bapla_RBP)	Lactophage receptor-binding protein C-terminal head domain	Caudo_bapla_RBP is a family of proteins expressed from ORF18 of the Lactococcus P2-like phage. This is one of three protein domains, shoulders, neck, and head, that form the phage tail base-plate. In the overall structure this head domain exists as s ...	Caudo_bapla_RBP is a family of proteins expressed from ORF18 of the Lactococcus P2-like phage. This is one of three protein domains, shoulders, neck, and head, that form the phage tail base-plate. In the overall structure this head domain exists as six trimers, and is necessary for specific recognition of the receptors at the host cell surface. Siphoviridae are the P2-like Caudovirales of Lactococcus [1]. This family now includes DUF1914. Family Baseplate, Pfam:PF16774, is the ORF15 or shoulder component of the base-plate complex.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
O [auth R]	LACTOCOCCAL PHAGE P2 ORF16	-	symbiont genome ejection through host cell envelope biological process involved in interspecies interaction between organisms symbiont genome ejection through host cell envelope, long flexible tail mechanism symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction	virus tail virion component virus tail, baseplate
M [auth P], N [auth Q]	LACTOCOCCAL PHAGE P2 ORF15	-	symbiont genome ejection through host cell envelope biological process involved in interspecies interaction between organisms symbiont genome ejection through host cell envelope, long flexible tail mechanism symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction	virus tail virion component
D, E, F, J, K D, E, F, J, K, L	CAMELID VHH5	-	-	-
A, B, C, G, H A, B, C, G, H, I	PUTATIVE RECEPTOR BINDING PROTEIN	-	virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction receptor-mediated virion attachment to host cell entry receptor-mediated virion attachment to host cell cell adhesion cellular process symbiont entry into host cell symbiont entry into host	virus tail virion component virus tail, baseplate

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
O [auth R]	IPR048782	Phage tail base-plate attachment protein, C-terminal barrel domain	Domain
O [auth R]	IPR043073	Baseplate protein Gp16, domain D4	Homologous Superfamily
O [auth R]	IPR048784	Phage tail base-plate attachment protein, N0 domain	Domain
O [auth R]	IPR048783	Phage tail base-plate attachment protein, C-terminal insertion domain	Domain
O [auth R]	IPR043075	Baseplate protein Gp16, domain 1 and 2	Homologous Superfamily
O [auth R]	IPR031861	Phage tail base-plate attachment protein, N-terminal barrel domain	Domain
M [auth P], N [auth Q]	IPR048272	Distal tail protein, C-terminal domain	Domain
M [auth P], N [auth Q]	IPR031899	Distal tail protein, N-terminal domain	Domain
A, B, C, G, H A, B, C, G, H, I	IPR048779	Receptor binding protein, neck domain	Domain
A, B, C, G, H A, B, C, G, H, I	IPR048780	Receptor-binding protein, N-terminal shoulder domain	Domain
A, B, C, G, H A, B, C, G, H, I	IPR008982	Adenovirus pIV-like, attachment domain	Homologous Superfamily
A, B, C, G, H A, B, C, G, H, I	IPR015027	Receptor-binding protein of phage tail base-plate Siphoviridae, head	Domain