Annotations: 3BRF

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d3brfa1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	DNA-binding protein LAG-1 (CSL)	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
C [auth A]	d3brfa2	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	p53-like transcription factors	DNA-binding protein LAG-1 (CSL)	DNA-binding protein LAG-1 (CSL)	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
C [auth A]	d3brfa3	All beta proteins	beta-Trefoil	DNA-binding protein LAG-1 (CSL)	DNA-binding protein LAG-1 (CSL)	DNA-binding protein LAG-1 (CSL)	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	TIG_7	e3brfA3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: TIG_7	ECOD (1.6)
C [auth A]	LAG1-DNAbind	e3brfA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: LAG1-DNAbind	ECOD (1.6)
C [auth A]	BTD	e3brfA1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: BTD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	2.60.40.1450	Mainly Beta	Sandwich	Immunoglobulin-like	LAG1, DNA binding domain	CATH (4.3.0)
C [auth A]	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
C [auth A]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	DNA (5'-D(DTPDTPDAPDCPDTPDGPDTPDGPDGPDGPDAPDAPDAPDGP*DA)-3')	-	-	-
B [auth C]	DNA (5'-D(DAPDAPDTPDCPDTPDTPDTPDCPDCPDCPDAPDCPDAPDGP*DT)-3')	-	-	-
D	Protein lin-12	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding signaling receptor binding Notch binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding molecular transducer activity transmembrane signaling receptor activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding signaling receptor binding Notch binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development cellular developmental process cell differentiation cellular process cell fate specification cell fate commitment regulation of cellular process mesodermal cell differentiation developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development cellular developmental process cell differentiation cellular process cell fate specification cell fate commitment regulation of cellular process mesodermal cell differentiation regulation of developmental process mesoderm morphogenesis regulation of cell differentiation embryo development regulation of mesodermal cell fate specification regulation of mesodermal cell differentiation mesodermal cell fate commitment animal organ morphogenesis mesoderm formation regulation of anatomical structure morphogenesis mesoderm development mesodermal cell fate specification regulation of biological process formation of primary germ layer regulation of animal organ morphogenesis regulation of cell fate commitment biological regulation embryonic morphogenesis animal organ development tissue development gastrulation tissue morphogenesis anatomical structure morphogenesis cell fate commitment involved in formation of primary germ layer regulation of cell fate specification anatomical structure formation involved in morphogenesis behavior egg-laying behavior reproductive process multicellular organismal reproductive process reproductive behavior dauer larval development dauer exit exit from diapause dormancy process positive regulation of biological process positive regulation of developmental process positive regulation of mesodermal cell fate specification positive regulation of cell differentiation positive regulation of cell fate specification positive regulation of cell fate commitment positive regulation of mesodermal cell differentiation positive regulation of cellular process sleep vulval development positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of vulval development regulation of cellular component organization extracellular matrix organization cellular component organization cellular component organization or biogenesis regulation of basement membrane organization regulation of extracellular matrix organization extracellular structure organization external encapsulating structure organization basement membrane organization cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication Notch signaling pathway signal transduction cell projection morphogenesis cell projection organization cell morphogenesis	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle cell periphery apical part of cell membrane RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane CSL-Notch-Mastermind transcription factor complex
C [auth A]	Lin-12 and glp-1 phenotype protein 1, isoform a	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
D	IPR010660	Notch, NOD domain	Domain
D	IPR013111	EGF-like domain, extracellular	Domain
D	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
D	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
D	IPR051022	Notch Signaling and Cell Fate Determination	Family
D	IPR000800	Notch domain	Domain
D	IPR013032	EGF-like, conserved site	Conserved Site
D	IPR000742	EGF-like domain	Domain
D	IPR002110	Ankyrin repeat	Repeat
D	IPR049883	NOTCH1 EGF-like calcium-binding domain	Domain
D	IPR035993	Notch-like domain superfamily	Homologous Superfamily
D	IPR011656	Notch, NODP domain	Domain
D	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
D	IPR001881	EGF-like calcium-binding domain	Domain
D	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.