3HB7 | pdb_00003hb7

The Crystal Structure of an Isochorismatase-like Hydrolase from Alkaliphilus metalliredigens to 2.3A

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3hb7a1	Alpha and beta proteins (a/b)	Isochorismatase-like hydrolases	Isochorismatase-like hydrolases	automated matches	automated matches	(Alkaliphilus metalliredigens QYMF ) [TaxId: 293826 ],	SCOPe (2.08)
A	d3hb7a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Alkaliphilus metalliredigens QYMF ) [TaxId: 293826 ],	SCOPe (2.08)
B [auth C]	d3hb7c_	Alpha and beta proteins (a/b)	Isochorismatase-like hydrolases	Isochorismatase-like hydrolases	automated matches	automated matches	(Alkaliphilus metalliredigens QYMF ) [TaxId: 293826 ],	SCOPe (2.08)
C [auth B]	d3hb7b1	Alpha and beta proteins (a/b)	Isochorismatase-like hydrolases	Isochorismatase-like hydrolases	automated matches	automated matches	(Alkaliphilus metalliredigens QYMF ) [TaxId: 293826 ],	SCOPe (2.08)
C [auth B]	d3hb7b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Alkaliphilus metalliredigens QYMF ) [TaxId: 293826 ],	SCOPe (2.08)
D	d3hb7d1	Alpha and beta proteins (a/b)	Isochorismatase-like hydrolases	Isochorismatase-like hydrolases	automated matches	automated matches	(Alkaliphilus metalliredigens QYMF ) [TaxId: 293826 ],	SCOPe (2.08)
D	d3hb7d2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Alkaliphilus metalliredigens QYMF ) [TaxId: 293826 ],	SCOPe (2.08)
E	d3hb7e_	Alpha and beta proteins (a/b)	Isochorismatase-like hydrolases	Isochorismatase-like hydrolases	automated matches	automated matches	(Alkaliphilus metalliredigens QYMF ) [TaxId: 293826 ],	SCOPe (2.08)
F	d3hb7f_	Alpha and beta proteins (a/b)	Isochorismatase-like hydrolases	Isochorismatase-like hydrolases	automated matches	automated matches	(Alkaliphilus metalliredigens QYMF ) [TaxId: 293826 ],	SCOPe (2.08)
G	d3hb7g_	Alpha and beta proteins (a/b)	Isochorismatase-like hydrolases	Isochorismatase-like hydrolases	automated matches	automated matches	(Alkaliphilus metalliredigens QYMF ) [TaxId: 293826 ],	SCOPe (2.08)
H	d3hb7h_	Alpha and beta proteins (a/b)	Isochorismatase-like hydrolases	Isochorismatase-like hydrolases	automated matches	automated matches	(Alkaliphilus metalliredigens QYMF ) [TaxId: 293826 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Isochorismatase-like hydrolases	8065863	4000591	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Isochorismatase-like hydrolases	8065864	3001778	SCOP2 (2022-06-29)
B [auth C]	SCOP2B Superfamily	Isochorismatase-like hydrolases	8065864	3001778	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Isochorismatase-like hydrolases	8065864	3001778	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Isochorismatase-like hydrolases	8065864	3001778	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Isochorismatase-like hydrolases	8065864	3001778	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Isochorismatase-like hydrolases	8065864	3001778	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Isochorismatase-like hydrolases	8065864	3001778	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Isochorismatase-like hydrolases	8065864	3001778	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Isochorismatase	e3hb7A1	A: a/b three-layered sandwiches	X: Isochorismatase-like hydrolases (From Topology)	H: Isochorismatase-like hydrolases (From Topology)	T: Isochorismatase-like hydrolases	F: Isochorismatase	ECOD (1.6)
B [auth C]	Isochorismatase	e3hb7C1	A: a/b three-layered sandwiches	X: Isochorismatase-like hydrolases (From Topology)	H: Isochorismatase-like hydrolases (From Topology)	T: Isochorismatase-like hydrolases	F: Isochorismatase	ECOD (1.6)
C [auth B]	Isochorismatase	e3hb7B1	A: a/b three-layered sandwiches	X: Isochorismatase-like hydrolases (From Topology)	H: Isochorismatase-like hydrolases (From Topology)	T: Isochorismatase-like hydrolases	F: Isochorismatase	ECOD (1.6)
D	Isochorismatase	e3hb7D1	A: a/b three-layered sandwiches	X: Isochorismatase-like hydrolases (From Topology)	H: Isochorismatase-like hydrolases (From Topology)	T: Isochorismatase-like hydrolases	F: Isochorismatase	ECOD (1.6)
E	Isochorismatase	e3hb7E1	A: a/b three-layered sandwiches	X: Isochorismatase-like hydrolases (From Topology)	H: Isochorismatase-like hydrolases (From Topology)	T: Isochorismatase-like hydrolases	F: Isochorismatase	ECOD (1.6)
F	Isochorismatase	e3hb7F1	A: a/b three-layered sandwiches	X: Isochorismatase-like hydrolases (From Topology)	H: Isochorismatase-like hydrolases (From Topology)	T: Isochorismatase-like hydrolases	F: Isochorismatase	ECOD (1.6)
G	Isochorismatase	e3hb7G1	A: a/b three-layered sandwiches	X: Isochorismatase-like hydrolases (From Topology)	H: Isochorismatase-like hydrolases (From Topology)	T: Isochorismatase-like hydrolases	F: Isochorismatase	ECOD (1.6)
H	Isochorismatase	e3hb7H1	A: a/b three-layered sandwiches	X: Isochorismatase-like hydrolases (From Topology)	H: Isochorismatase-like hydrolases (From Topology)	T: Isochorismatase-like hydrolases	F: Isochorismatase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.850	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Isochorismatase-like	CATH (4.3.0)
B [auth C]	3.40.50.850	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Isochorismatase-like	CATH (4.3.0)
C [auth B]	3.40.50.850	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Isochorismatase-like	CATH (4.3.0)
D	3.40.50.850	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Isochorismatase-like	CATH (4.3.0)
E	3.40.50.850	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Isochorismatase-like	CATH (4.3.0)
F	3.40.50.850	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Isochorismatase-like	CATH (4.3.0)
G	3.40.50.850	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Isochorismatase-like	CATH (4.3.0)
H	3.40.50.850	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Isochorismatase-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], C [auth B], D, E, A, B [auth C], C [auth B], D, E, F, G, H	PF00857	Isochorismatase domain (Isochorismatase)	Isochorismatase domain	This is a domain found in hydrolase enzymes. This domain is responsible for the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate. It shows a typical helix-sheet-helix sandwich structural architecture, with ...	This is a domain found in hydrolase enzymes. This domain is responsible for the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate. It shows a typical helix-sheet-helix sandwich structural architecture, with a central beta--sheet made of six parallel strands, three alpha -helices on one side and two on the other [3,4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth B], D, E, A, B [auth C], C [auth B], D, E, F, G, H	Isochorismatase hydrolase	hydrolase activity catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth B], D, E, A, B [auth C], C [auth B], D, E, F, G, H	IPR000868	Isochorismatase-like domain	Domain
A, B [auth C], C [auth B], D, E, A, B [auth C], C [auth B], D, E, F, G, H	IPR050272	Isochorismatase-like hydrolase	Family
A, B [auth C], C [auth B], D, E, A, B [auth C], C [auth B], D, E, F, G, H	IPR036380	Isochorismatase-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.