Annotations: 3ISU

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	RGC domain	8018865	4000412	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RGC domain-like	8054338	3000236	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KOG2128	e3isuA1	A: a+b complex topology	X: RGC domain (From Topology)	H: RGC domain (From Topology)	T: RGC domain	F: KOG2128	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ras GTPase-activating-like protein IQGAP3	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding myosin VI binding myosin light chain binding myosin VI light chain binding myosin binding GTPase regulator activity small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding myosin VI binding myosin light chain binding myosin VI light chain binding myosin binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity calmodulin binding	regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process cellular response to stimulus response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade ERK1 and ERK2 cascade signal transduction cellular component organization regulation of cellular component size cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size assembly of actomyosin apparatus involved in cytokinesis mitotic actomyosin contractile ring assembly cytoskeleton-dependent cytokinesis mitotic cytokinetic process actomyosin contractile ring assembly mitotic cytokinesis mitotic cell cycle cellular component biogenesis actomyosin contractile ring assembly actin filament organization cellular component assembly cortical actin cytoskeleton organization actin filament-based process cell cycle cell cycle process assembly of actomyosin apparatus involved in mitotic cytokinesis actin cytoskeleton organization actomyosin structure organization cortical cytoskeleton organization actin filament organization cytokinesis mitotic actomyosin contractile ring assembly actin filament organization organelle organization mitotic cell cycle process cytokinetic process actomyosin contractile ring organization cell division supramolecular fiber organization cytoskeleton organization developmental process epithelium development cell population proliferation mammary gland development gland development animal organ development tissue development mammary gland epithelium development anatomical structure development epithelial cell proliferation mammary gland epithelial cell proliferation small GTPase-mediated signal transduction Ras protein signal transduction positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus regulation of cell communication positive regulation of signaling multicellular organismal process regulation of developmental process positive regulation of cell population proliferation positive regulation of mammary gland epithelial cell proliferation positive regulation of developmental process regulation of multicellular organismal process positive regulation of epithelial cell proliferation regulation of mammary gland epithelial cell proliferation regulation of cell population proliferation positive regulation of multicellular organismal process regulation of epithelial cell proliferation cell cycle phase transition G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle phase transition negative regulation of metabolic process negative regulation of biological process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process	cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm cell-cell junction anchoring junction cell junction cytosol plasma membrane membrane lateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001715	Calponin homology domain	Domain
A	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A	IPR000048	IQ motif, EF-hand binding site	Binding Site
A	IPR001936	Ras GTPase-activating domain	Domain
A	IPR023152	Ras GTPase-activating protein, conserved site	Conserved Site
A	IPR000593	RasGAP protein, C-terminal	Domain
A	IPR036872	CH domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q86VI3	non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adrenal cortex carcinoma autism spectrum disorder breast carcinoma endometriosis invasive ductal breast carcinoma malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor atopic eczema Autism Spectrum Disorders non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adrenal cortex carcinoma autism spectrum disorder breast carcinoma endometriosis invasive ductal breast carcinoma malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor atopic eczema Autism Spectrum Disorders cystic fibrosis glioblastoma large cell medulloblastoma malignant glioma nasopharyngeal carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis atypical teratoid rhabdoid tumor breast cancer ductal breast carcinoma in situ hepatocellular carcinoma lung adenocarcinoma malignant pancreatic neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.