3JCF | pdb_00003jcf

Cryo-EM structure of the magnesium channel CorA in the closed symmetric magnesium-bound state

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	CorA soluble domain-like	8037836	3000209	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Magnesium transport protein CorA, transmembrane region	8042853	3000358	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Magnesium transport protein CorA, transmembrane region	8042853	3000358	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	CorA soluble domain-like	8037836	3000209	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	CorA soluble domain-like	8037836	3000209	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Magnesium transport protein CorA, transmembrane region	8042853	3000358	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	CorA soluble domain-like	8037836	3000209	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Magnesium transport protein CorA, transmembrane region	8042853	3000358	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	CorA soluble domain-like	8037836	3000209	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Magnesium transport protein CorA, transmembrane region	8042853	3000358	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CorA_N	e3jcfA2	A: a+b three layers	X: CorA soluble domain-like (From Topology)	H: CorA soluble domain-like (From Topology)	T: CorA soluble domain-like	F: CorA_N	ECOD (1.6)
A	CorA_C	e3jcfA1	A: extended segments	X: Magnesium transport protein CorA, transmembrane region (From Topology)	H: Magnesium transport protein CorA, transmembrane region (From Topology)	T: Magnesium transport protein CorA, transmembrane region	F: CorA_C	ECOD (1.6)
B	CorA_N	e3jcfB2	A: a+b three layers	X: CorA soluble domain-like (From Topology)	H: CorA soluble domain-like (From Topology)	T: CorA soluble domain-like	F: CorA_N	ECOD (1.6)
B	CorA_C	e3jcfB1	A: extended segments	X: Magnesium transport protein CorA, transmembrane region (From Topology)	H: Magnesium transport protein CorA, transmembrane region (From Topology)	T: Magnesium transport protein CorA, transmembrane region	F: CorA_C	ECOD (1.6)
C	CorA_N	e3jcfC1	A: a+b three layers	X: CorA soluble domain-like (From Topology)	H: CorA soluble domain-like (From Topology)	T: CorA soluble domain-like	F: CorA_N	ECOD (1.6)
C	CorA_C	e3jcfC2	A: extended segments	X: Magnesium transport protein CorA, transmembrane region (From Topology)	H: Magnesium transport protein CorA, transmembrane region (From Topology)	T: Magnesium transport protein CorA, transmembrane region	F: CorA_C	ECOD (1.6)
D	CorA_N	e3jcfD1	A: a+b three layers	X: CorA soluble domain-like (From Topology)	H: CorA soluble domain-like (From Topology)	T: CorA soluble domain-like	F: CorA_N	ECOD (1.6)
D	CorA_C	e3jcfD2	A: extended segments	X: Magnesium transport protein CorA, transmembrane region (From Topology)	H: Magnesium transport protein CorA, transmembrane region (From Topology)	T: Magnesium transport protein CorA, transmembrane region	F: CorA_C	ECOD (1.6)
E	CorA_N	e3jcfE2	A: a+b three layers	X: CorA soluble domain-like (From Topology)	H: CorA soluble domain-like (From Topology)	T: CorA soluble domain-like	F: CorA_N	ECOD (1.6)
E	CorA_C	e3jcfE1	A: extended segments	X: Magnesium transport protein CorA, transmembrane region (From Topology)	H: Magnesium transport protein CorA, transmembrane region (From Topology)	T: Magnesium transport protein CorA, transmembrane region	F: CorA_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.460.20	Alpha Beta	2-Layer Sandwich	Beta Polymerase	domain 2	CATH (4.3.0)
A	1.20.58.340	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	3.30.460.20	Alpha Beta	2-Layer Sandwich	Beta Polymerase	domain 2	CATH (4.3.0)
B	1.20.58.340	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
C	3.30.460.20	Alpha Beta	2-Layer Sandwich	Beta Polymerase	domain 2	CATH (4.3.0)
C	1.20.58.340	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D	3.30.460.20	Alpha Beta	2-Layer Sandwich	Beta Polymerase	domain 2	CATH (4.3.0)
D	1.20.58.340	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
E	3.30.460.20	Alpha Beta	2-Layer Sandwich	Beta Polymerase	domain 2	CATH (4.3.0)
E	1.20.58.340	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF01544	CorA-like Mg2+ transporter protein (CorA)	CorA-like Mg2+ transporter protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Magnesium transport protein CorA	cation binding transition metal ion binding ion binding binding metal ion binding cobalt ion binding small molecule binding magnesium ion binding cobalt ion transmembrane transporter activity monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity cation binding transition metal ion binding ion binding binding metal ion binding cobalt ion binding small molecule binding magnesium ion binding cobalt ion transmembrane transporter activity monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity transmembrane transporter activity magnesium ion transmembrane transporter activity identical protein binding protein binding	transport magnesium ion transport monoatomic ion transmembrane transport magnesium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport transport magnesium ion transport monoatomic ion transmembrane transport magnesium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis cobalt ion transport transition metal ion transport	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR002523	Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB	Family
A, B, C, D, E	IPR045863	CorA, transmembrane region	Homologous Superfamily
A, B, C, D, E	IPR004488	Magnesium/cobalt transport protein CorA	Family
A, B, C, D, E	IPR045861	CorA, cytoplasmic domain	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E	OPM				CorA metal ion transporters (MIT)

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	CorA Superfamily Ion Transporters	CorA Mg²⁺ Transporter, cryo-EM structure, closed state

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.