3PNT | pdb_00003pnt

Crystal Structure of the Streptococcus pyogenes NAD+ glycohydrolase SPN in complex with IFS, the Immunity Factor for SPN

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Protein immunity factor IFS-like	8052674	3002133	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Protein immunity factor IFS-like	8052674	3002133	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	IFS	e3pntD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Immunity Factor for SPN (From Topology)	T: Immunity Factor for SPN	F: IFS	ECOD (1.6)
B	IFS	e3pntB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Immunity Factor for SPN (From Topology)	T: Immunity Factor for SPN	F: IFS	ECOD (1.6)
C	NADase_NGA	e3pntC1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: NADase_NGA	ECOD (1.6)
A	NADase_NGA	e3pntA1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: NADase_NGA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	1.25.40.520	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
B	1.25.40.520	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
C	1.10.10.1660	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Nicotine adenine dinucleotide glycohydrolase, helical linker domain	CATH (4.3.0)
A	1.10.10.1660	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Nicotine adenine dinucleotide glycohydrolase, helical linker domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D	PF16718	Immunity factor for SPN (IFS)	Immunity factor for SPN	Immunity factor for SPN (IFS) binds to and inhibits the SPN toxin [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D	Immunity factor for SPN	-	-	-
A, C	NAD+-glycohydrolase	hydrolase activity catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D	IPR038509	IFS superfamily	Homologous Superfamily
B, D	IPR032002	Immunity factor for SPN	Family
A, C	IPR041934	NAD glycohydrolase, helical linker domain	Homologous Superfamily
A, C	IPR057561	NAD glycohydrolase, translocation F5/8 type C domain	Domain
A, C	IPR010900	Nicotine adenine dinucleotide glycohydrolase, catalytic domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.