3RPX | pdb_00003rpx

Crystal structure of complement component 1, q subcomponent binding protein, C1QBP

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	MAM33	e3rpxC1	A: a+b two layers	X: Acidic mitochondrial matrix protein p32-like	H: Acidic mitochondrial matrix protein p32 (From Topology)	T: Acidic mitochondrial matrix protein p32	F: MAM33	ECOD (1.6)
B	MAM33	e3rpxB1	A: a+b two layers	X: Acidic mitochondrial matrix protein p32-like	H: Acidic mitochondrial matrix protein p32 (From Topology)	T: Acidic mitochondrial matrix protein p32	F: MAM33	ECOD (1.6)
A	MAM33	e3rpxA1	A: a+b two layers	X: Acidic mitochondrial matrix protein p32-like	H: Acidic mitochondrial matrix protein p32 (From Topology)	T: Acidic mitochondrial matrix protein p32	F: MAM33	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.10.280.10	Alpha Beta	Roll	Mitochondrial Matrix Protein	Chain A	CATH (4.3.0)
B	3.10.280.10	Alpha Beta	Roll	Mitochondrial Matrix Protein	Chain A	CATH (4.3.0)
A	3.10.280.10	Alpha Beta	Roll	Mitochondrial Matrix Protein	Chain A	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Complement component 1 Q subcomponent-binding protein	complement component C1q complex binding opsonin binding protein-containing complex binding protein binding binding complement binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity nuclease inhibitor activity enzyme inhibitor activity deoxyribonuclease inhibitor activity adrenergic receptor binding signaling receptor binding complement component C1q complex binding opsonin binding protein-containing complex binding protein binding binding complement binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity nuclease inhibitor activity enzyme inhibitor activity deoxyribonuclease inhibitor activity adrenergic receptor binding signaling receptor binding G protein-coupled receptor binding transcription factor binding RNA binding nucleic acid binding mRNA binding protein-RNA adaptor activity protein-macromolecule adaptor activity C5-methylcytidine-containing RNA reader activity molecular adaptor activity kininogen binding ribonucleoprotein complex binding ribosome binding mitochondrial ribosome binding transcription corepressor activity transcription regulator activity transcription coregulator activity kinase binding protein kinase C binding enzyme binding protein kinase binding glycosaminoglycan binding carbohydrate derivative binding hyaluronic acid binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process negative regulation of biological process regulation of mRNA splicing, via spliceosome mRNA processing regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process negative regulation of mRNA splicing, via spliceosome cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process negative regulation of biological process regulation of mRNA splicing, via spliceosome mRNA processing regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process negative regulation of mRNA splicing, via spliceosome negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process RNA processing negative regulation of mRNA processing regulation of biological process negative regulation of metabolic process primary metabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process negative regulation of mRNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of mRNA processing RNA splicing biological regulation regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process regulation of RNA splicing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process negative regulation of RNA splicing RNA splicing, via transesterification reactions negative regulation of biosynthetic process mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of mRNA metabolic process regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress negative regulation of DNA repair regulation of response to stress negative regulation of double-strand break repair recombinational repair negative regulation of double-strand break repair via homologous recombination double-strand break repair via homologous recombination DNA repair double-strand break repair negative regulation of response to stimulus DNA recombination DNA metabolic process regulation of DNA repair regulation of double-strand break repair via homologous recombination negative regulation of DNA recombination regulation of response to stimulus negative regulation of DNA metabolic process regulation of DNA metabolic process positive regulation of response to biotic stimulus negative regulation of RIG-I signaling pathway pattern recognition receptor signaling pathway regulation of signal transduction response to biotic stimulus intracellular signal transduction cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus regulation of RIG-I signaling pathway RIG-I signaling pathway defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus intracellular receptor signaling pathway signaling negative regulation of signaling negative regulation of cytoplasmic pattern recognition receptor signaling pathway negative regulation of intracellular signal transduction positive regulation of biological process regulation of cytoplasmic pattern recognition receptor signaling pathway negative regulation of cell communication positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of intracellular signal transduction innate immune response response to external biotic stimulus regulation of signaling positive regulation of innate immune response defense response defense response to symbiont negative regulation of signal transduction negative regulation of immune system process immune system process regulation of cell communication adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response complement activation humoral immune response mediated by circulating immunoglobulin leukocyte mediated immunity complement activation, classical pathway immunoglobulin mediated immune response adaptive immune response immune effector process B cell mediated immunity apoptotic process cell death programmed cell death positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process negative regulation of response to biotic stimulus regulation of defense response to virus response to virus defense response to virus negative regulation of response to external stimulus negative regulation of defense response negative regulation of defense response to virus positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading multicellular organismal process regulation of type II interferon production type II interferon production cytokine production regulation of cytokine production regulation of multicellular organismal process negative regulation of type II interferon production negative regulation of cytokine production negative regulation of multicellular organismal process multi-multicellular organism process positive regulation of locomotion regulation of cell motility regulation of developmental process regulation of trophoblast cell migration regulation of reproductive process reproductive process positive regulation of cell migration positive regulation of developmental process multicellular organism development ameboidal-type cell migration positive regulation of cell motility anatomical structure development regulation of cell migration cell migration cell motility female pregnancy embryo implantation locomotion positive regulation of reproductive process trophoblast cell migration developmental process positive regulation of trophoblast cell migration regulation of locomotion positive regulation of multicellular organismal process multi-organism reproductive process negative regulation of RNA biosynthetic process DNA-templated transcription transcription by RNA polymerase II regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of humoral immune response regulation of immune effector process regulation of complement activation catabolic process macromolecule catabolic process nucleobase-containing compound catabolic process nucleic acid catabolic process mitochondrial RNA metabolic process mitochondrial RNA catabolic process RNA catabolic process intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of dendritic cell chemotaxis dendritic cell chemotaxis positive regulation of chemotaxis taxis positive regulation of mononuclear cell migration regulation of mononuclear cell migration cell chemotaxis chemotaxis regulation of dendritic cell chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration positive regulation of leukocyte migration positive regulation of leukocyte chemotaxis regulation of chemotaxis leukocyte migration dendritic cell migration cellular response to chemical stimulus response to chemical mononuclear cell migration leukocyte chemotaxis ribonucleoprotein complex biogenesis organelle assembly membraneless organelle assembly cellular component biogenesis cellular component organization ribosome biogenesis organelle organization cellular component assembly cytosolic ribosome assembly cellular component organization or biogenesis ribosome assembly positive regulation of neutrophil chemotaxis neutrophil migration granulocyte migration positive regulation of granulocyte chemotaxis regulation of neutrophil chemotaxis regulation of neutrophil migration neutrophil chemotaxis regulation of granulocyte chemotaxis myeloid leukocyte migration positive regulation of neutrophil migration granulocyte chemotaxis positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling MDA-5 signaling pathway regulation of MDA-5 signaling pathway negative regulation of MDA-5 signaling pathway mitochondrial translation positive regulation of protein metabolic process regulation of mitochondrial gene expression positive regulation of translation mitochondrial gene expression protein biosynthetic process positive regulation of macromolecule biosynthetic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process regulation of protein metabolic process translation positive regulation of gene expression regulation of mitochondrial translation regulation of translation positive regulation of mitochondrial translation regulation of interleukin-12 production negative regulation of interleukin-12 production interleukin-12 production	presynapse cellular anatomical structure synapse cell junction presynaptic active zone membrane intracellular anatomical structure cytoplasm cytosol glutamatergic synapse extracellular region extracellular space membrane-bounded organelle intracellular organelle presynapse cellular anatomical structure synapse cell junction presynaptic active zone membrane intracellular anatomical structure cytoplasm cytosol glutamatergic synapse extracellular region extracellular space membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle nucleolus intracellular organelle lumen organelle lumen membraneless organelle nuclear lumen cell surface cell periphery plasma membrane GABA-ergic synapse mitochondrial matrix

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR036561	Mitochondrial glycoprotein superfamily	Homologous Superfamily
A, B, C	IPR003428	Mitochondrial glycoprotein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q07021	breast carcinoma combined oxidative phosphorylation deficiency 33 breast cancer glioblastoma lymphoplasmacytic lymphoma Mammary Neoplasms, Human ovarian cancer psoriasis lung adenocarcinoma pancreatic ductal adenocarcinoma rheumatoid arthritis lung cancer nasopharyngeal carcinoma plasma cell myeloma Sjogren syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.