3S24 | pdb_00003s24

Crystal structure of human mRNA guanylyltransferase

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
G [auth F]	mRNA_cap_C	e3s24F4	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: mRNA_cap_C	ECOD (1.6)
G [auth F]	mRNA_cap_enzyme	e3s24F3	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: mRNA_cap_enzyme	ECOD (1.6)
F [auth G]	mRNA_cap_C	e3s24G4	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: mRNA_cap_C	ECOD (1.6)
F [auth G]	mRNA_cap_enzyme	e3s24G3	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: mRNA_cap_enzyme	ECOD (1.6)
E	mRNA_cap_C	e3s24E4	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: mRNA_cap_C	ECOD (1.6)
E	mRNA_cap_enzyme	e3s24E3	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: mRNA_cap_enzyme	ECOD (1.6)
D	mRNA_cap_C	e3s24D4	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: mRNA_cap_C	ECOD (1.6)
D	mRNA_cap_enzyme	e3s24D3	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: mRNA_cap_enzyme	ECOD (1.6)
C	mRNA_cap_C	e3s24C1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: mRNA_cap_C	ECOD (1.6)
C	mRNA_cap_enzyme	e3s24C2	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: mRNA_cap_enzyme	ECOD (1.6)
B	mRNA_cap_C	e3s24B1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: mRNA_cap_C	ECOD (1.6)
B	mRNA_cap_enzyme	e3s24B2	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: mRNA_cap_enzyme	ECOD (1.6)
A	mRNA_cap_C	e3s24A3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: mRNA_cap_C	ECOD (1.6)
A	mRNA_cap_enzyme	e3s24A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: mRNA_cap_enzyme	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
G [auth F]	3.30.470.30	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
G [auth F]	4.10.87.10	Few Secondary Structures	Irregular	mRNA Capping Enzyme	Chain	CATH (4.3.0)
G [auth F]	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
F [auth G]	3.30.470.30	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
F [auth G]	4.10.87.10	Few Secondary Structures	Irregular	mRNA Capping Enzyme	Chain	CATH (4.3.0)
F [auth G]	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
E	3.30.470.30	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
E	4.10.87.10	Few Secondary Structures	Irregular	mRNA Capping Enzyme	Chain	CATH (4.3.0)
E	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
D	3.30.470.30	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
D	4.10.87.10	Few Secondary Structures	Irregular	mRNA Capping Enzyme	Chain	CATH (4.3.0)
D	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
C	3.30.470.30	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
C	4.10.87.10	Few Secondary Structures	Irregular	mRNA Capping Enzyme	Chain	CATH (4.3.0)
C	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
B	3.30.470.30	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
B	4.10.87.10	Few Secondary Structures	Irregular	mRNA Capping Enzyme	Chain	CATH (4.3.0)
B	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
A	3.30.470.30	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
A	4.10.87.10	Few Secondary Structures	Irregular	mRNA Capping Enzyme	Chain	CATH (4.3.0)
A	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	PF03919	mRNA capping enzyme, C-terminal domain (mRNA_cap_C)	mRNA capping enzyme, C-terminal domain		Domain
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	PF01331	mRNA capping enzyme, catalytic domain (mRNA_cap_enzyme)	mRNA capping enzyme, catalytic domain	This family represents the ATP binding catalytic domain of the mRNA capping enzyme.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	mRNA-capping enzyme	guanylyltransferase activity RNA guanylyltransferase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid transferase activity catalytic activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding guanylyltransferase activity RNA guanylyltransferase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid transferase activity catalytic activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding mRNA guanylyltransferase activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds polynucleotide 5'-phosphatase activity phosphatase activity hydrolase activity pyrophosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides inorganic triphosphate phosphatase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein guanyl nucleotide binding GTP binding guanyl ribonucleotide binding mRNA 5'-triphosphate monophosphatase activity	7-methylguanosine mRNA capping RNA metabolic process primary metabolic process 7-methylguanosine RNA capping RNA capping gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process mRNA processing mRNA metabolic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process biosynthetic process 7-methylguanosine mRNA capping RNA metabolic process primary metabolic process 7-methylguanosine RNA capping RNA capping gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process mRNA processing mRNA metabolic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process biosynthetic process RNA 5'-end processing metabolic process cellular process RNA processing macromolecule metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	IPR001339	mRNA capping enzyme, adenylation domain	Domain
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	IPR051029	mRNA Capping Enzyme and RNA Phosphatase	Family
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	IPR017074	mRNA capping enzyme, bifunctional	Family
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	IPR020422	Dual specificity protein phosphatase domain	Domain
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	IPR000340	Dual specificity phosphatase, catalytic domain	Domain
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	IPR013846	mRNA capping enzyme, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E, A, B, C, D, E, F [auth G], G [auth F]	Pharos: O60942	astrocytic tumor large cell medulloblastoma medulloblastoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor lymphoplasmacytic lymphoma oligodendroglioma psoriasis glioblastoma malignant ependymoma osteosarcoma psychotic disorder