3SJQ

Crystal structure of a small conductance potassium channel splice variant complexed with calcium-calmodulin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3sjqa_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d3sjqb_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d3sjqc1	Membrane and cell surface proteins and peptides	Small-conductance potassium channel	Small-conductance potassium channel	Small-conductance potassium channel	Small-conductance potassium channel	rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d3sjqc2	Artifacts	Tags	Tags	Tags	C-terminal Tags	rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d3sjqd1	Membrane and cell surface proteins and peptides	Small-conductance potassium channel	Small-conductance potassium channel	Small-conductance potassium channel	Small-conductance potassium channel	rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d3sjqd2	Artifacts	Tags	Tags	Tags	C-terminal Tags	rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Calmodulin binding domain (CaMBD)-like	8038298	3002034	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Calmodulin binding domain (CaMBD)-like	8038298	3002034	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EF-hand_7_8	e3sjqA2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
A	EF-hand_7_5	e3sjqA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
B	EF-hand_7_8	e3sjqB2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
B	EF-hand_7_5	e3sjqB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
C	CaMBD	e3sjqC1	A: extended segments	X: Small-conductance potassium channel (From Topology)	H: Small-conductance potassium channel (From Topology)	T: Small-conductance potassium channel	F: CaMBD	ECOD (1.6)
D	CaMBD	e3sjqD1	A: extended segments	X: Small-conductance potassium channel (From Topology)	H: Small-conductance potassium channel (From Topology)	T: Small-conductance potassium channel	F: CaMBD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	1.10.287.70	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
D	1.10.287.70	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Calmodulin	cytoskeletal protein binding titin binding protein binding binding enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity enzyme binding adenylate cyclase binding cytoskeletal protein binding titin binding protein binding binding enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity enzyme binding adenylate cyclase binding phosphatidylinositol 3-kinase binding channel regulator activity ion channel regulator activity calcium channel regulator activity transporter regulator activity nitric-oxide synthase regulator activity molecular function inhibitor activity transporter inhibitor activity calcium channel inhibitor activity ion channel inhibitor activity channel inhibitor activity cyclase regulator activity cyclase activator activity adenylate cyclase regulator activity adenylate cyclase activator activity protein serine/threonine kinase activator activity kinase activator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity nitric-oxide synthase binding cation binding ion binding calcium ion binding metal ion binding small molecule binding protein domain specific binding signaling receptor binding type 3 metabotropic glutamate receptor binding glutamate receptor binding G protein-coupled receptor binding G protein-coupled glutamate receptor binding transmembrane transporter binding kinase binding protein kinase binding calcium-dependent protein binding	organelle localization by membrane tethering localization organelle localization cellular process membrane docking heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation organelle localization by membrane tethering localization organelle localization cellular process membrane docking heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of localization regulation of cellular process negative regulation of ion transmembrane transporter activity negative regulation of calcium ion transmembrane transporter activity intracellular calcium ion homeostasis negative regulation of biological process negative regulation of ryanodine-sensitive calcium-release channel activity negative regulation of transport calcium ion transport negative regulation of cation transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization regulation of cation channel activity inorganic cation transmembrane transport maintenance of location transmembrane transport regulation of molecular function release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis negative regulation of calcium ion transmembrane transport cellular localization inorganic ion homeostasis transport negative regulation of cation channel activity homeostatic process monoatomic ion transmembrane transport negative regulation of monoatomic ion transport positive regulation of biological process regulation of transmembrane transporter activity calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport negative regulation of transmembrane transport regulation of transporter activity maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport positive regulation of sequestering of calcium ion negative regulation of monoatomic ion transmembrane transport negative regulation of release of sequestered calcium ion into cytosol intracellular monoatomic cation homeostasis negative regulation of cellular process monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion positive regulation of cellular process regulation of monoatomic ion transmembrane transporter activity calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion negative regulation of transporter activity negative regulation of molecular function negative regulation of calcium ion transport cellular homeostasis regulation of ryanodine-sensitive calcium-release channel activity regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport response to stimulus response to metal ion response to chemical response to calcium ion protein localization establishment of protein localization establishment of protein localization to mitochondrial membrane mitochondrial membrane organization cellular component organization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis mitochondrion organization membrane organization establishment of protein localization to membrane localization within membrane protein localization to membrane organelle organization establishment of protein localization to organelle macromolecule localization protein localization to organelle protein localization to mitochondrion establishment of protein localization to mitochondrion sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum cellular component disassembly catabolic process macroautophagy protein-containing complex organization autophagy protein-containing complex disassembly autophagosome maturation autophagosome membrane docking metabolic process process utilizing autophagic mechanism import into cell regulation of cellular component organization synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling regulation of synaptic vesicle endocytosis regulation of endocytosis synaptic vesicle endocytosis regulation of vesicle-mediated transport endocytosis cellular response to interferon-beta response to peptide response to interferon-beta response to cytokine cellular response to cytokine stimulus regulation of cytokinesis regulation of cell cycle process cytokinesis regulation of cell division cell division cell cycle regulation of cell cycle cell cycle process mitochondrion-endoplasmic reticulum membrane tethering cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition mitotic cell cycle mitotic cell cycle phase transition regulated exocytosis modulation of chemical synaptic transmission signaling synaptic vesicle exocytosis cell communication regulation of regulated secretory pathway synaptic signaling regulation of secretion by cell secretion by cell signal release trans-synaptic signaling regulation of signaling neurotransmitter secretion secretion regulation of neurotransmitter transport regulation of synaptic vesicle exocytosis export from cell cell-cell signaling neurotransmitter transport regulation of secretion chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling exocytosis regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of exocytosis regulation of cell communication regulation of cardiac muscle contraction cardiac muscle contraction muscle contraction muscle system process regulation of muscle system process striated muscle contraction regulation of striated muscle contraction regulation of muscle contraction biological process involved in interspecies interaction between organisms immune response response to other organism defense response response to type II interferon defense response to symbiont response to external stimulus cellular response to type II interferon response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus cellular response to stimulus positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction positive regulation of receptor signaling pathway via STAT regulation of signal transduction positive regulation of receptor signaling pathway via JAK-STAT positive regulation of response to stimulus regulation of receptor signaling pathway via JAK-STAT signal transduction cell surface receptor signaling pathway regulation of response to stimulus regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT positive regulation of signaling regulation of action potential regulation of cardiac muscle cell action potential action potential cardiac muscle cell action potential regulation of membrane potential response to amine response to nitrogen compound response to amphetamine detection of stimulus detection of chemical stimulus detection of calcium ion	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton cytoplasm cytosol membrane-bounded organelle cell projection intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton cytoplasm cytosol membrane-bounded organelle cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection protein-containing complex transmembrane transporter complex membrane membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex axon synapse neuron projection axon terminus presynapse distal axon calyx of Held cell junction neuron projection terminus sarcomere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex mitochondrion intracellular membrane-bounded organelle myelin sheath centrosome microtubule organizing center cytosolic region presynaptic cytosol catalytic complex growth cone site of polarized growth nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen voltage-gated potassium channel complex plasma membrane protein complex plasma membrane potassium channel complex cell periphery Schaffer collateral - CA1 synapse polymeric cytoskeletal fiber spindle microtubule microtubule postsynapse postsynaptic cytosol
C, D	Small conductance calcium-activated potassium channel protein 2	protein binding binding protein domain specific binding cytoskeletal protein binding alpha-actinin binding actinin binding monoatomic cation transmembrane transporter activity calcium-activated cation channel activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity potassium channel activity monoatomic ion-gated channel activity calcium-activated potassium channel activity protein binding binding protein domain specific binding cytoskeletal protein binding alpha-actinin binding actinin binding monoatomic cation transmembrane transporter activity calcium-activated cation channel activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity potassium channel activity monoatomic ion-gated channel activity calcium-activated potassium channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ligand-gated monoatomic cation channel activity metal ion transmembrane transporter activity transmembrane transporter activity small conductance calcium-activated potassium channel activity identical protein binding protein homodimerization activity protein dimerization activity calmodulin binding inward rectifier potassium channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity voltage-gated potassium channel activity	transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport cardiac muscle cell membrane repolarization heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction membrane repolarization signaling atrial cardiac muscle cell to AV node cell signaling regulation of heart contraction membrane repolarization during cardiac muscle cell action potential regulation of system process cell-cell signaling involved in cardiac conduction cardiac muscle contraction striated muscle contraction cell communication circulatory system process membrane repolarization during atrial cardiac muscle cell action potential actin filament-based process regulation of multicellular organismal process regulation of biological quality atrial cardiac muscle cell to AV node cell communication cell communication involved in cardiac conduction blood circulation cardiac muscle cell contraction regulation of biological process atrial cardiac muscle cell action potential biological regulation cell-cell signaling action potential actin filament-based movement muscle contraction muscle system process membrane repolarization during action potential regulation of blood circulation cardiac conduction atrial cardiac muscle cell membrane repolarization cardiac muscle cell action potential actin-mediated cell contraction heart contraction regulation of membrane potential trans-synaptic signaling regulation of signaling regulation of cellular process modulation of chemical synaptic transmission chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of localization regulation of potassium ion transport regulation of transport regulation of monoatomic ion transport positive regulation of biological process positive regulation of potassium ion transport positive regulation of transport positive regulation of monoatomic ion transport regulation of metal ion transport regulation of neuronal synaptic plasticity regulation of synaptic plasticity regulation of monoatomic ion transmembrane transport regulation of potassium ion transmembrane transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane sarcolemma T-tubule intracellular anatomical structure intracellular membraneless organelle cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane sarcolemma T-tubule intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex cell surface membrane-bounded organelle endoplasmic reticulum smooth endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system glutamatergic synapse neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection dendrite dendritic tree cell body neuronal cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR050145	Centrin/CML-like	Family
A, B	IPR002048	EF-hand domain	Domain
A, B	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, B	IPR011992	EF-hand domain pair	Homologous Superfamily
C, D	IPR015449	Potassium channel, calcium-activated, SK	Family
C, D	IPR013099	Potassium channel domain	Domain
C, D	IPR036122	SK, calmodulin-binding domain superfamily	Homologous Superfamily
C, D	IPR004178	Calmodulin-binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.