Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyGalpha insert domain-like 8056792 3000669 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyRas-like P-loop GTPases 8056791 3002022 SCOP2B (2022-06-29)
D [auth R]SCOP2B SuperfamilyG protein-coupled receptor-like 8091150 3000473 SCOP2B (2022-06-29)
D [auth R]SCOP2B SuperfamilyLysozyme-like 8033861 3001879 SCOP2B (2022-06-29)
C [auth G]SCOP2B SuperfamilyTransducin (heterotrimeric G protein), gamma chain 8070796 3001771 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AG-alphae3sn6A1 A: alpha arraysX: Transducin (alpha subunit), insertion domain (From Topology)H: Transducin (alpha subunit), insertion domain (From Topology)T: Transducin (alpha subunit), insertion domainF: G-alphaECOD (1.6)
ARase3sn6A2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
D [auth R]7tm_1_3e3sn6R4 A: alpha bundlesX: Family A G protein-coupled receptor-like (From Topology)H: Family A G protein-coupled receptor-like (From Topology)T: Family A G protein-coupled receptor-likeF: 7tm_1_3ECOD (1.6)
D [auth R]Phage_lysozyme_2e3sn6R1 A: a+b complex topologyX: Lysozyme-like (From Homology)H: Lysozyme-likeT: Lysozyme-likeF: Phage_lysozyme_2ECOD (1.6)
BANAPC4_WD40_3e3sn6B1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_3ECOD (1.6)
C [auth G]G-gammae3sn6G1 A: extended segmentsX: Transducin (heterotrimeric G protein), gamma chain (From Topology)H: Transducin (heterotrimeric G protein), gamma chain (From Topology)T: Transducin (heterotrimeric G protein), gamma chainF: G-gammaECOD (1.6)
E [auth N]V-set_12e3sn6N1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
E [auth N]Llama heavy chain VH domain VH Lama glama (llama) IGHV3S6*01, IGHV3S2*01, IGHJ3*01 V-DOMAIN VH IG (VH) IMGT (202449-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
E [auth N]Heavy ChainIGHV1 -guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SAbDab (2024-12-13)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00503G-protein alpha subunit (G-alpha)G-protein alpha subunitG proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like ...G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site [3]. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA [3].
Domain
D [auth R]PF00959Phage lysozyme (Phage_lysozyme)Phage lysozymeThis family includes lambda phage lysozyme and E. coli endolysin.Domain
D [auth R]PF000017 transmembrane receptor (rhodopsin family) (7tm_1)7 transmembrane receptor (rhodopsin family)- Family
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
C [auth G]PF00631GGL domain (G-gamma)GGL domainG-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins [1]. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA [2] ...G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins [1]. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA [2]. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta [2]. All organisms that posses a G-beta possess a G-gamma [2].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
D [auth R]Endolysin,Beta-2 adrenergic receptor
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
C [auth G]Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
E [auth N]Camelid antibody VHH fragment---

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
D [auth R]PharosP07550