3ZNI

Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RING/U-box like	8079711	3000160	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	RING/U-box like	8079711	3000160	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	RING/U-box like	8079711	3000160	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	RING/U-box like	8079711	3000160	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	UBC-like	8040137	3000570	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	UBC-like	8040137	3000570	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	UBC-like	8040137	3000570	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	UBC-like	8040137	3000570	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ubiquitin-like	8043829	3000157	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Ubiquitin-like	8043829	3000157	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Ubiquitin-like	8043829	3000157	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Ubiquitin-like	8043829	3000157	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Cbl_N2	e3zniA7	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: Cbl_N2	ECOD (1.6)
A	Cbl_N	e3zniA5	A: alpha bundles	X: N-cbl like	H: N-terminal domain of cbl (N-cbl) (From Topology)	T: N-terminal domain of cbl (N-cbl)	F: Cbl_N	ECOD (1.6)
A	Cbl_N3	e3zniA6	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: Cbl_N3	ECOD (1.6)
A	zf-C3HC4_3	e3zniA8	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: zf-C3HC4_3	ECOD (1.6)
M	Cbl_N2	e3zniM1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: Cbl_N2	ECOD (1.6)
M	Cbl_N	e3zniM2	A: alpha bundles	X: N-cbl like	H: N-terminal domain of cbl (N-cbl) (From Topology)	T: N-terminal domain of cbl (N-cbl)	F: Cbl_N	ECOD (1.6)
M	Cbl_N3	e3zniM3	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: Cbl_N3	ECOD (1.6)
M	zf-C3HC4_3	e3zniM4	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: zf-C3HC4_3	ECOD (1.6)
E	Cbl_N2	e3zniE7	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: Cbl_N2	ECOD (1.6)
E	Cbl_N	e3zniE5	A: alpha bundles	X: N-cbl like	H: N-terminal domain of cbl (N-cbl) (From Topology)	T: N-terminal domain of cbl (N-cbl)	F: Cbl_N	ECOD (1.6)
E	Cbl_N3	e3zniE6	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: Cbl_N3	ECOD (1.6)
E	zf-C3HC4_3	e3zniE8	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: zf-C3HC4_3	ECOD (1.6)
I	Cbl_N2	e3zniI7	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: Cbl_N2	ECOD (1.6)
I	Cbl_N	e3zniI5	A: alpha bundles	X: N-cbl like	H: N-terminal domain of cbl (N-cbl) (From Topology)	T: N-terminal domain of cbl (N-cbl)	F: Cbl_N	ECOD (1.6)
I	Cbl_N3	e3zniI6	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: Cbl_N3	ECOD (1.6)
I	zf-C3HC4_3	e3zniI8	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: zf-C3HC4_3	ECOD (1.6)
G	UQ_con	e3zniG1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: UQ_con	ECOD (1.6)
O	UQ_con	e3zniO1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: UQ_con	ECOD (1.6)
C	UQ_con	e3zniC1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: UQ_con	ECOD (1.6)
K	UQ_con	e3zniK1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: UQ_con	ECOD (1.6)
D	ubiquitin_1	e3zniD1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: ubiquitin_1	ECOD (1.6)
H	ubiquitin_1	e3zniH1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: ubiquitin_1	ECOD (1.6)
P	ubiquitin_1	e3zniP1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: ubiquitin_1	ECOD (1.6)
L	ubiquitin_1	e3zniL1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: ubiquitin_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.930.20	Mainly Alpha	Up-down Bundle	Transcription Elongation Factor S-II	Chain A	CATH (4.3.0)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
A	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
A	3.30.40.10	Alpha Beta	2-Layer Sandwich	Herpes Virus-1	Zinc/RING finger domain, C3HC4 (zinc finger)	CATH (4.3.0)
M	1.20.930.20	Mainly Alpha	Up-down Bundle	Transcription Elongation Factor S-II	Chain A	CATH (4.3.0)
M	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
M	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
M	3.30.40.10	Alpha Beta	2-Layer Sandwich	Herpes Virus-1	Zinc/RING finger domain, C3HC4 (zinc finger)	CATH (4.3.0)
E	1.20.930.20	Mainly Alpha	Up-down Bundle	Transcription Elongation Factor S-II	Chain A	CATH (4.3.0)
E	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
E	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
E	3.30.40.10	Alpha Beta	2-Layer Sandwich	Herpes Virus-1	Zinc/RING finger domain, C3HC4 (zinc finger)	CATH (4.3.0)
I	1.20.930.20	Mainly Alpha	Up-down Bundle	Transcription Elongation Factor S-II	Chain A	CATH (4.3.0)
I	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
I	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
I	3.30.40.10	Alpha Beta	2-Layer Sandwich	Herpes Virus-1	Zinc/RING finger domain, C3HC4 (zinc finger)	CATH (4.3.0)
G	3.10.110.10	Alpha Beta	Roll	Ubiquitin Conjugating Enzyme	Ubiquitin Conjugating Enzyme	CATH (4.3.0)
O	3.10.110.10	Alpha Beta	Roll	Ubiquitin Conjugating Enzyme	Ubiquitin Conjugating Enzyme	CATH (4.3.0)
C	3.10.110.10	Alpha Beta	Roll	Ubiquitin Conjugating Enzyme	Ubiquitin Conjugating Enzyme	CATH (4.3.0)
K	3.10.110.10	Alpha Beta	Roll	Ubiquitin Conjugating Enzyme	Ubiquitin Conjugating Enzyme	CATH (4.3.0)
D	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
H	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
P	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
L	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E, I, M	PF02262	CBL proto-oncogene N-terminal domain 1 (Cbl_N)	CBL proto-oncogene N-terminal domain 1	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.	Domain
A, E, I, M	PF00097	Zinc finger, C3HC4 type (RING finger) (zf-C3HC4)	Zinc finger, C3HC4 type (RING finger)	The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid [1]. Many protein ...	The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid [1]. Many proteins containing a RING finger play a key role in the ubiquitination pathway [2].	Domain
A, E, I, M	PF02762	CBL proto-oncogene N-terminus, SH2-like domain (Cbl_N3)	CBL proto-oncogene N-terminus, SH2-like domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.	Domain
A, E, I, M	PF02761	CBL proto-oncogene N-terminus, EF hand-like domain (Cbl_N2)	CBL proto-oncogene N-terminus, EF hand-like domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.	Domain
C, G, K, O	PF00179	Ubiquitin-conjugating enzyme (UQ_con)	Ubiquitin-conjugating enzyme	Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cystein ...	Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine [4, 5].	Domain
D, H, L, P	PF00240	Ubiquitin family (ubiquitin)	Ubiquitin family	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E, I, M	E3 UBIQUITIN-PROTEIN LIGASE CBL-B	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoprotein binding phosphotyrosine residue binding protein binding protein phosphorylated amino acid binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoprotein binding phosphotyrosine residue binding protein binding protein phosphorylated amino acid binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity SH3 domain binding protein domain specific binding protein tyrosine kinase binding kinase binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding transition metal ion binding zinc ion binding	cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response biological regulation T cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response cellular process antigen receptor-mediated signaling pathway activation of immune response regulation protein catabolic process at synapse catabolic process metabolic process regulation of catabolic process regulation of metabolic process regulation protein catabolic process at postsynapse primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process regulation of protein modification process positive regulation of protein metabolic process regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process protein ubiquitination positive regulation of macromolecule metabolic process regulation of protein modification by small protein conjugation or removal protein modification process positive regulation of cellular process positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of post-translational protein modification regulation of protein metabolic process regulation of macromolecule metabolic process macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of protein catabolic process positive regulation of catabolic process regulation of protein catabolic process immune system development multicellular organismal process regulation of T cell anergy lymphocyte anergy regulation of lymphocyte anergy positive regulation of lymphocyte anergy positive regulation of T cell tolerance induction multicellular organism development positive regulation of T cell anergy anatomical structure development regulation of multicellular organismal process regulation of T cell tolerance induction T cell anergy system development developmental process T cell tolerance induction positive regulation of multicellular organismal process regulation of tolerance induction positive regulation of tolerance induction tolerance induction protein localization establishment of protein localization cellular localization NLS-bearing protein import into nucleus nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport negative regulation of signaling negative regulation of biological process regulation of signal transduction regulation of antigen receptor-mediated signaling pathway negative regulation of antigen receptor-mediated signaling pathway negative regulation of cell communication negative regulation of cellular process regulation of signaling negative regulation of response to stimulus regulation of T cell receptor signaling pathway negative regulation of signal transduction negative regulation of T cell receptor signaling pathway negative regulation of immune system process regulation of cell communication platelet-derived growth factor receptor-alpha signaling pathway platelet-derived growth factor receptor signaling pathway regulation of platelet-derived growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway regulation of platelet-derived growth factor receptor-alpha signaling pathway enzyme-linked receptor protein signaling pathway negative regulation of lymphocyte proliferation regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation alpha-beta T cell proliferation T cell activation lymphocyte proliferation alpha-beta T cell activation regulation of leukocyte proliferation cell population proliferation regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion mononuclear cell proliferation regulation of cell population proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation regulation of alpha-beta T cell proliferation cell adhesion cell-cell adhesion CD4-positive, alpha-beta T cell activation regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation CD4-positive, alpha-beta T cell proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of alpha-beta T cell proliferation regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell proliferation regulation of mononuclear cell proliferation negative regulation of alpha-beta T cell activation regulation of lymphocyte activation intracellular signal transduction import into cell regulation of localization regulation of cellular component organization receptor internalization postsynaptic neurotransmitter receptor internalization regulation of receptor internalization vesicle-mediated transport vesicle-mediated transport in synapse cellular component organization regulation of postsynaptic neurotransmitter receptor internalization regulation of biological quality cellular component organization or biogenesis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis endocytosis receptor-mediated endocytosis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane microdomain membrane raft membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane microdomain membrane raft membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen synapse cell junction glutamatergic synapse postsynapse
B, F, J, N	TYROSINE-PROTEIN KINASE ZAP-70	protein binding binding signaling receptor binding phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein binding binding signaling receptor binding phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding non-membrane spanning protein tyrosine kinase activity	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling regulation of cell communication cellular process positive regulation of signaling developmental process cellular developmental process cell differentiation thymic T cell selection multicellular organismal process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation immune system process negative thymic T cell selection anatomical structure development T cell differentiation negative T cell selection T cell selection leukocyte differentiation immune response-regulating cell surface receptor signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response T cell receptor signaling pathway regulation of immune response antigen receptor-mediated signaling pathway activation of immune response adaptive immune response beta selection alpha-beta T cell differentiation alpha-beta T cell activation positive regulation of cell population proliferation regulation of leukocyte activation regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell proliferation regulation of cell activation positive regulation of cell activation alpha-beta T cell proliferation lymphocyte proliferation positive regulation of leukocyte activation regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of alpha-beta T cell activation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process positive regulation of leukocyte cell-cell adhesion leukocyte proliferation leukocyte cell-cell adhesion positive regulation of cell-cell adhesion regulation of alpha-beta T cell proliferation positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation positive thymic T cell selection positive T cell selection leukocyte migration mononuclear cell migration lymphocyte migration cell migration T cell migration cell motility B cell activation biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus protein phosphorylation phosphorylation primary metabolic process peptidyl-tyrosine modification macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process peptidyl-tyrosine phosphorylation protein modification process phosphorus metabolic process T cell aggregation lymphocyte aggregation leukocyte aggregation cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway regulation of leukocyte differentiation regulation of cell differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development positive regulation of cell development positive regulation of alpha-beta T cell differentiation regulation of developmental process regulation of alpha-beta T cell differentiation regulation of T cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of lymphocyte differentiation regulation of multicellular organismal development regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation	cell-cell junction cellular anatomical structure anchoring junction cell junction cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex T cell receptor complex receptor complex intracellular anatomical structure cell-cell junction cellular anatomical structure anchoring junction cell junction cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex T cell receptor complex receptor complex intracellular anatomical structure cytoplasm cytosol immunological synapse extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane side of membrane
C, G, K, O	UBIQUITIN-CONJUGATING ENZYME E2 D2	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ubiquitin conjugating enzyme activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein conjugating enzyme activity transferase activity catalytic activity ubiquitin-protein transferase activity ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding ubiquitin-like protein ligase activity ubiquitin protein ligase activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein polyubiquitination catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein K48-linked ubiquitination protein autoubiquitination	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol nucleus extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex
D, H, L, P	POLYUBIQUITIN-C	protein tag activity molecular tag activity ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding RNA binding organic cyclic compound binding nucleic acid binding	catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis metabolic process cellular process protein metabolic process macromolecule metabolic process protein ubiquitination macromolecule modification catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis metabolic process cellular process protein metabolic process macromolecule metabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane cytoplasm membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane cytoplasm vesicle organelle membrane endocytic vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol endosome membrane endosome endomembrane system mitochondrial membrane mitochondrion organelle outer membrane organelle envelope mitochondrial envelope mitochondrial outer membrane outer membrane cell periphery plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E, I, M	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, E, I, M	IPR024159	Adaptor protein Cbl, PTB domain	Domain
A, E, I, M	IPR039520	E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass	Domain
A, E, I, M	IPR003153	Adaptor protein Cbl, N-terminal helical	Domain
A, E, I, M	IPR011992	EF-hand domain pair	Homologous Superfamily
A, E, I, M	IPR015940	Ubiquitin-associated domain	Domain
A, E, I, M	IPR018957	Zinc finger, C3HC4 RING-type	Domain
A, E, I, M	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
A, E, I, M	IPR024162	Adaptor protein Cbl	Family
A, E, I, M	IPR014741	Adaptor protein Cbl, EF hand-like	Domain
A, E, I, M	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, E, I, M	IPR014742	Adaptor protein Cbl, SH2-like domain	Domain
A, E, I, M	IPR036537	Adaptor protein Cbl, N-terminal domain superfamily	Homologous Superfamily
A, E, I, M	IPR001841	Zinc finger, RING-type	Domain
B, F, J, N	IPR017441	Protein kinase, ATP binding site	Binding Site
B, F, J, N	IPR036860	SH2 domain superfamily	Homologous Superfamily
B, F, J, N	IPR008266	Tyrosine-protein kinase, active site	Active Site
B, F, J, N	IPR023420	Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily	Homologous Superfamily
B, F, J, N	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
B, F, J, N	IPR000980	SH2 domain	Domain
B, F, J, N	IPR000719	Protein kinase domain	Domain
B, F, J, N	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
B, F, J, N	IPR012234	Tyrosine-protein kinase, non-receptor SYK/ZAP-70	Family
B, F, J, N	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B, F, J, N	IPR035838	SYK/ZAP-70, N-terminal SH2 domain	Domain
B, F, J, N	IPR050198	Non-receptor tyrosine kinases involved in cell signaling	Family
C, G, K, O	IPR000608	Ubiquitin-conjugating enzyme E2	Domain
C, G, K, O	IPR016135	Ubiquitin-conjugating enzyme/RWD-like	Homologous Superfamily
C, G, K, O	IPR023313	Ubiquitin-conjugating enzyme, active site	Active Site
D, H, L, P	IPR019954	Ubiquitin conserved site	Conserved Site
D, H, L, P	IPR000626	Ubiquitin-like domain	Domain
D, H, L, P	IPR019956	Ubiquitin domain	Domain
D, H, L, P	IPR050158	Ubiquitin and ubiquitin-like	Family
D, H, L, P	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, E, I, M	Pharos: Q13191	experimental autoimmune encephalomyelitis multiple sclerosis pancreatic intraductal papillary-mucinous carcinoma Pick disease acute myeloid leukemia Barrett esophagus dermatomyositis glioblastoma malignant pancreatic neoplasm Multiple Sclerosis, Acute Fulminating ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor adrenoleukodystrophy congenital anemia experimental autoimmune encephalomyelitis multiple sclerosis pancreatic intraductal papillary-mucinous carcinoma Pick disease acute myeloid leukemia Barrett esophagus dermatomyositis glioblastoma malignant pancreatic neoplasm Multiple Sclerosis, Acute Fulminating ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor adrenoleukodystrophy congenital anemia esophageal adenocarcinoma juvenile dermatomyositis medulloblastoma myopathy pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma astrocytic tumor lung cancer oligodendroglioma
B, F, J, N	Pharos: P43403	severe combined immunodeficiency autoimmune disease, multisystem, infantile-onset, 2 combined immunodeficiency due to ZAP70 deficiency primary immunodeficiency disease T cell immunodeficiency primary cancer cutaneous lupus erythematosus interstitial cystitis Omenn syndrome colorectal cancer hematologic disease lymphatic system disease osteosarcoma thrombocytopenia due to immune destruction MHC class II deficiency severe combined immunodeficiency autoimmune disease, multisystem, infantile-onset, 2 combined immunodeficiency due to ZAP70 deficiency primary immunodeficiency disease T cell immunodeficiency primary cancer cutaneous lupus erythematosus interstitial cystitis Omenn syndrome colorectal cancer hematologic disease lymphatic system disease osteosarcoma thrombocytopenia due to immune destruction MHC class II deficiency ovarian cancer susceptibility to respiratory infections associated with CD8alpha chain mutation
C, G, K, O	Pharos: P62837	astrocytic tumor esophageal squamous cell carcinoma malignant ependymoma osteosarcoma atypical teratoid rhabdoid tumor glioblastoma malignant glioma ovarian cancer breast cancer large cell medulloblastoma malignant mesothelioma plasma cell myeloma
D, H, L, P	Pharos: P0CG48	acute myeloid leukemia heart disease myocardial infarction pancreatic ductal adenocarcinoma astrocytic tumor lung cancer osteosarcoma renal cell carcinoma glioblastoma malignant pancreatic neoplasm ovarian cancer

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, E, I, M	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048
B, F, J, N	PTR	Parent Component: TYR RESID: AA0039 , AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048 , O4'-phospho-L-tyrosine MOD:00048