4ERN | pdb_00004ern

Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein at 1.80 A

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Tandem AAA-ATPase domain	8045074	4000282	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RecA-like P-loop NTPases	8054245	3002019	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Helicase_C_1	e4ernA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Helicase_C_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	TFIIH basal transcription factor complex helicase XPB subunit	DNA binding binding damaged DNA binding nucleic acid binding chromatin binding promoter-specific chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding DNA binding binding damaged DNA binding nucleic acid binding chromatin binding promoter-specific chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity nucleic acid conformation isomerase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity 3'-5' DNA helicase activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA macromolecular conformation isomerase activity	developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular process system development localization macromolecule localization intracellular protein localization RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process macromolecule metabolic process apoptotic process cell death programmed cell death regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process chromosome organization DNA conformation change DNA metabolic process cellular component organization DNA topological change organelle organization cellular component organization or biogenesis cellular response to stimulus response to stimulus transcription-coupled nucleotide-excision repair cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair response to light stimulus response to radiation response to abiotic stimulus response to UV UV protection animal organ development embryonic organ development embryo development regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition mitotic cell cycle regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle mitotic cell cycle process cell cycle regulation of cell cycle mitotic cell cycle phase transition cell cycle process DNA-templated transcription initiation transcription initiation at RNA polymerase II promoter transcription elongation by RNA polymerase II DNA-templated transcription elongation response to oxidative stress	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle transcription preinitiation complex protein-DNA complex RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle transcription preinitiation complex protein-DNA complex RNA polymerase II, holoenzyme membrane-enclosed lumen transferase complex intracellular organelle lumen nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen protein kinase complex transcription factor TFIIH holo complex cyclin-dependent protein kinase holoenzyme complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex nuclear cyclin-dependent protein kinase holoenzyme complex nucleotide-excision repair factor 3 complex nucleotide-excision repair complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032830	Helicase XPB/Ssl2, N-terminal domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR006935	Helicase/UvrB, N-terminal	Domain
A	IPR001650	Helicase, C-terminal domain-like	Domain
A	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A	IPR032438	ERCC3/RAD25/XPB helicase, C-terminal domain	Domain
A	IPR001161	Helicase XPB/Ssl2	Family
A	IPR050615	ATP-dependent DNA Helicase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P19447	xeroderma pigmentosum trichothiodystrophy 2, photosensitive xeroderma pigmentosum group B trichothiodystrophy Cockayne syndrome peripheral nervous system disease peripheral neuropathy Arsenic Poisoning photosensitive trichothiodystrophy squamous cell carcinoma cutaneous melanoma lung cancer Pick disease xeroderma pigmentosum-Cockayne syndrome complex cataract xeroderma pigmentosum trichothiodystrophy 2, photosensitive xeroderma pigmentosum group B trichothiodystrophy Cockayne syndrome peripheral nervous system disease peripheral neuropathy Arsenic Poisoning photosensitive trichothiodystrophy squamous cell carcinoma cutaneous melanoma lung cancer Pick disease xeroderma pigmentosum-Cockayne syndrome complex cataract intellectual disability osteosarcoma skin basal cell carcinoma trichothiodystrophy 1, photosensitive leukodystrophy melanoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.