4JON

Crystal structure of a centrosomal protein 170kDa, transcript variant beta (CEP170) from Homo sapiens at 2.15 A resolution (PSI Community Target, Sundstrom)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SMAD/FHA domain-like	8063041	3000137	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SMAD/FHA domain-like	8063041	3000137	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SMAD/FHA domain-like	8063041	3000137	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SMAD/FHA domain-like	8063041	3000137	SCOP2B (2022-06-29)
E	SCOP2 Family	FHA domain	8063040	4002605	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	SMAD/FHA domain-like	8063041	3000137	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FHA	e4jonA1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: FHA	ECOD (1.6)
B	FHA	e4jonB1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: FHA	ECOD (1.6)
C	FHA	e4jonC1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: FHA	ECOD (1.6)
D	FHA	e4jonD1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: FHA	ECOD (1.6)
E	FHA	e4jonE1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: FHA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.200.20	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
B	2.60.200.20	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
C	2.60.200.20	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
D	2.60.200.20	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
E	2.60.200.20	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF00498	FHA domain (FHA)	FHA domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Centrosomal protein of 170 kDa	-	-	intracellular organelle microtubule organizing center cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle centriole intracellular membraneless organelle microtubule cytoskeleton cytoplasm cytosol membrane-bounded organelle protein-containing complex intracellular organelle microtubule organizing center cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle centriole intracellular membraneless organelle microtubule cytoskeleton cytoplasm cytosol membrane-bounded organelle protein-containing complex cell projection cilium intracellular protein-containing complex centriolar subdistal appendage plasma membrane bounded cell projection spindle centrosome polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR029300	CEP170, C-terminal	Domain
A, B, C, D, E	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR000253	Forkhead-associated (FHA) domain	Domain
A, B, C, D, E	IPR051176	Centrosomal and Immune Signaling Modulators	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E	Pharos: Q5SW79	attention deficit hyperactivity disorder, inattentive type diabetes mellitus medulloblastoma psoriasis ulcerative colitis chronic kidney disease gastric carcinoma osteosarcoma Sjogren syndrome Crohn disease lung cancer primitive neuroectodermal tumor tuberculosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.