5B4P | pdb_00005b4p

Complex structure of human C5a and its binding repebody

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Anaphylotoxins (complement system)	8037606	3000387	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Anaphylotoxins (complement system)	8037606	3000387	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	LRR_8_1	e5b4pC1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)
C	Internalin_N	e5b4pC2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: Internalin_N	ECOD (1.6)
A	LRR_8_1	e5b4pA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)
A	Internalin_N	e5b4pA2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: Internalin_N	ECOD (1.6)
D	ANATO	e5b4pD1	A: few secondary structure elements	X: Anaphylotoxins (complement system) (From Topology)	H: Anaphylotoxins (complement system) (From Topology)	T: Anaphylotoxins (complement system)	F: ANATO	ECOD (1.6)
B	ANATO	e5b4pB1	A: few secondary structure elements	X: Anaphylotoxins (complement system) (From Topology)	H: Anaphylotoxins (complement system) (From Topology)	T: Anaphylotoxins (complement system)	F: ANATO	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
A	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
D	1.20.91.20	Mainly Alpha	Up-down Bundle	Influenza Virus Matrix Protein	Chain A, domain 1	CATH (4.3.0)
B	1.20.91.20	Mainly Alpha	Up-down Bundle	Influenza Virus Matrix Protein	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D	PF01821	Anaphylotoxin-like domain (ANATO)	Anaphylotoxin-like domain	C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins. ...	C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	repebody	-	-	-
B, D	C5a anaphylatoxin	protein binding binding signaling receptor binding molecular function activator activity G protein-coupled receptor binding signaling receptor activator activity cytokine receptor binding chemokine activity molecular function regulator activity cytokine activity signaling receptor regulator activity chemokine receptor binding receptor ligand activity enzyme regulator activity protein binding binding signaling receptor binding molecular function activator activity G protein-coupled receptor binding signaling receptor activator activity cytokine receptor binding chemokine activity molecular function regulator activity cytokine activity signaling receptor regulator activity chemokine receptor binding receptor ligand activity enzyme regulator activity molecular function inhibitor activity peptidase regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process immune response biological regulation immunoglobulin mediated immune response adaptive immune response immune effector process regulation of response to stimulus immune system process B cell mediated immunity regulation of immune response activation of immune response cellular response to stimulus negative regulation of mononuclear cell migration negative regulation of locomotion regulation of cell motility regulation of cellular process negative regulation of biological process negative regulation of chemotaxis macrophage migration taxis negative regulation of macrophage chemotaxis cell migration regulation of mononuclear cell migration negative regulation of macrophage migration negative regulation of cell migration chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration response to external stimulus leukocyte migration negative regulation of leukocyte migration regulation of locomotion response to chemical negative regulation of response to external stimulus negative regulation of cell motility negative regulation of leukocyte chemotaxis regulation of response to external stimulus macrophage chemotaxis regulation of macrophage migration negative regulation of cellular process regulation of cell migration myeloid leukocyte migration cell motility locomotion cell chemotaxis regulation of macrophage chemotaxis negative regulation of response to stimulus regulation of chemotaxis cellular response to chemical stimulus negative regulation of immune system process mononuclear cell migration cellular process leukocyte chemotaxis multicellular organismal process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of vascular endothelial growth factor production regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression vascular endothelial growth factor production biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of vascular endothelial growth factor production regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process regulation of chemokine production chemokine production positive regulation of chemokine production cell surface receptor signaling pathway signaling signal transduction cell communication biological process involved in interspecies interaction between organisms disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing defense response response to stress inflammatory response G protein-coupled receptor signaling pathway complement activation, alternative pathway response to biotic stimulus innate immune response response to external biotic stimulus response to other organism defense response to symbiont defense response to other organism	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery protein-containing complex plasma membrane protein complex membrane extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex pore complex membrane attack complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D	IPR009048	Alpha-macroglobulin, receptor-binding	Domain
B, D	IPR041555	Macroglobulin domain MG3	Domain
B, D	IPR001599	Alpha-2-macroglobulin	Domain
B, D	IPR048843	Complement component 5, CUB domain	Domain
B, D	IPR018081	Anaphylatoxin, complement system	Homologous Superfamily
B, D	IPR018933	Netrin module, non-TIMP type	Domain
B, D	IPR001840	Anaphylatoxin, complement system domain	Domain
B, D	IPR041425	Complement C3/4/5, macroglobulin domain MG1	Domain
B, D	IPR011625	Alpha-2-macroglobulin, bait region domain	Domain
B, D	IPR001134	Netrin domain	Domain
B, D	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold	Homologous Superfamily
B, D	IPR011626	Alpha-macroglobulin-like, TED domain	Domain
B, D	IPR000020	Anaphylatoxin/fibulin	Domain
B, D	IPR036595	Alpha-macroglobulin, receptor-binding domain superfamily	Homologous Superfamily
B, D	IPR002890	Macroglobulin domain	Domain
B, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, D	IPR050473	Alpha-2-macroglobulin/Complement system	Family
B, D	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Homologous Superfamily
B, D	IPR040839	Macroglobulin domain MG4	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D	Pharos: P01031	complement component 5 deficiency rheumatoid arthritis peritonitis primary immunodeficiency disease pancreatic intraductal papillary-mucinous neoplasm psoriasis Secondary Peritonitis acquired paroxysmal nocturnal hemoglobinuria lung cancer malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis allergic rhinitis complement component 5 deficiency rheumatoid arthritis peritonitis primary immunodeficiency disease pancreatic intraductal papillary-mucinous neoplasm psoriasis Secondary Peritonitis acquired paroxysmal nocturnal hemoglobinuria lung cancer malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis allergic rhinitis atypical hemolytic-uremic syndrome malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor seborrheic infantile dermatitis atypical teratoid rhabdoid tumor glioblastoma malignant mesothelioma neuromyelitis optica ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.