5GPJ | pdb_00005gpj

Crystal Structure of Proton-Pumping Pyrophosphatase

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Membrane-integral pyrophosphatase-like	8092366	3002599	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Membrane-integral pyrophosphatase-like	8092366	3002599	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Membrane-integral pyrophosphatase-like	8092366	3002599	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Membrane-integral pyrophosphatase-like	8092366	3002599	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	H_PPase	e5gpjA1	A: alpha bundles	X: Na/H pumping membrane integral pyrophosphatase (From Topology)	H: Na/H pumping membrane integral pyrophosphatase (From Topology)	T: Na/H pumping membrane integral pyrophosphatase	F: H_PPase	ECOD (1.6)
B	H_PPase	e5gpjB1	A: alpha bundles	X: Na/H pumping membrane integral pyrophosphatase (From Topology)	H: Na/H pumping membrane integral pyrophosphatase (From Topology)	T: Na/H pumping membrane integral pyrophosphatase	F: H_PPase	ECOD (1.6)
C	H_PPase	e5gpjC1	A: alpha bundles	X: Na/H pumping membrane integral pyrophosphatase (From Topology)	H: Na/H pumping membrane integral pyrophosphatase (From Topology)	T: Na/H pumping membrane integral pyrophosphatase	F: H_PPase	ECOD (1.6)
D	H_PPase	e5gpjD1	A: alpha bundles	X: Na/H pumping membrane integral pyrophosphatase (From Topology)	H: Na/H pumping membrane integral pyrophosphatase (From Topology)	T: Na/H pumping membrane integral pyrophosphatase	F: H_PPase	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03030	Inorganic H+ pyrophosphatase (H_PPase)	Inorganic H+ pyrophosphatase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Pyrophosphate-energized vacuolar membrane proton pump	pyrophosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity inorganic diphosphate phosphatase activity hydrolase activity, acting on acid anhydrides catalytic activity monoatomic cation transmembrane transporter activity active monoatomic ion transmembrane transporter activity proton transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity pyrophosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity inorganic diphosphate phosphatase activity hydrolase activity, acting on acid anhydrides catalytic activity monoatomic cation transmembrane transporter activity active monoatomic ion transmembrane transporter activity proton transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity diphosphate hydrolysis-driven proton transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding	-	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane vacuole intracellular membrane-bounded organelle intracellular organelle bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR004131	Pyrophosphate-energised proton pump	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	Proton-translocating pyrophosphatase	Proton-translocating pyrophosphatase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Membrane-Integral Pyrophosphatases (M-PPases)	H⁺-translocating M-PPase

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.