Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042528 3000503 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042533 3000526 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042523 3000503 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042531 3000526 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042523 3000503 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042528 3000503 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042531 3000526 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042533 3000526 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042528 3000503 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042533 3000526 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042523 3000503 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042531 3000526 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyOuter membrane efflux proteins (OEP) 8037933 3000246 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyOuter membrane efflux proteins (OEP) 8037933 3000246 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyOuter membrane efflux proteins (OEP) 8037933 3000246 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyAcrZ-like 8090988 3002474 SCOP2B (2022-06-29)
NSCOP2B SuperfamilyAcrZ-like 8090988 3002474 SCOP2B (2022-06-29)
OSCOP2B SuperfamilyAcrZ-like 8090988 3002474 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
KACR_tran_4the5o66K8 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
KACR_tran_1ste5o66K5 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
KACR_tran_5the5o66K1 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
KACR_tran_3rde5o66K7 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
KACR_tran_6the5o66K3 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
KACR_tran_2nde5o66K2 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
KACR_tran_6th_1e5o66K6 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
LACR_tran_4the5o66L6 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
LACR_tran_1ste5o66L5 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
LACR_tran_5the5o66L1 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
LACR_tran_3rde5o66L8 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
LACR_tran_6the5o66L7 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
LACR_tran_2nde5o66L3 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
LACR_tran_6th_1e5o66L2 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
JACR_tran_4the5o66J4 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
JACR_tran_1ste5o66J8 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
JACR_tran_5the5o66J1 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
JACR_tran_3rde5o66J2 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
JACR_tran_6the5o66J7 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
JACR_tran_2nde5o66J6 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
JACR_tran_6th_1e5o66J5 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
AOEPe5o66A1 A: a+b duplicates or obligate multimersX: Outer membrane efflux proteins (OEP) (From Topology)H: Outer membrane efflux proteins (OEP) (From Topology)T: Outer membrane efflux proteins (OEP)F: OEPECOD (1.6)
BOEPe5o66B1 A: a+b duplicates or obligate multimersX: Outer membrane efflux proteins (OEP) (From Topology)H: Outer membrane efflux proteins (OEP) (From Topology)T: Outer membrane efflux proteins (OEP)F: OEPECOD (1.6)
COEPe5o66C1 A: a+b duplicates or obligate multimersX: Outer membrane efflux proteins (OEP) (From Topology)H: Outer membrane efflux proteins (OEP) (From Topology)T: Outer membrane efflux proteins (OEP)F: OEPECOD (1.6)
DPRK15030_2nde5o66D1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
DHlyD_D23_C_1e5o66D4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
DHlyD_2nde5o66D3 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
DHlyD_1ste5o66D2 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
EPRK15030_2nde5o66E1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
EHlyD_D23_C_1e5o66E2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
EHlyD_2nde5o66E3 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
EHlyD_1ste5o66E4 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
GPRK15030_2nde5o66G4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
GHlyD_D23_C_1e5o66G1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
GHlyD_2nde5o66G2 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
GHlyD_1ste5o66G3 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
IPRK15030_2nde5o66I1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
IHlyD_D23_C_1e5o66I2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
IHlyD_2nde5o66I4 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
IHlyD_1ste5o66I3 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
FPRK15030_2nde5o66F4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
FHlyD_D23_C_1e5o66F3 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
FHlyD_2nde5o66F2 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
FHlyD_1ste5o66F1 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
HPRK15030_2nde5o66H4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
HHlyD_D23_C_1e5o66H2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
HHlyD_2nde5o66H1 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
HHlyD_1ste5o66H3 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
MAcrZe5o66M1 A: extended segmentsX: Multidrug efflux pump accessory protein AcrZ (From Topology)H: Multidrug efflux pump accessory protein AcrZ (From Topology)T: Multidrug efflux pump accessory protein AcrZF: AcrZECOD (1.6)
NAcrZe5o66N1 A: extended segmentsX: Multidrug efflux pump accessory protein AcrZ (From Topology)H: Multidrug efflux pump accessory protein AcrZ (From Topology)T: Multidrug efflux pump accessory protein AcrZF: AcrZECOD (1.6)
OAcrZe5o66O1 A: extended segmentsX: Multidrug efflux pump accessory protein AcrZ (From Topology)H: Multidrug efflux pump accessory protein AcrZ (From Topology)T: Multidrug efflux pump accessory protein AcrZF: AcrZECOD (1.6)

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
J, K, L
ARO:3000216acrBProtein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter.CARD (3.3.0)
A, B, C
ARO:3000237TolCTolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
J, K, L
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpfluoroquinolone antibiotic, cephalosporin, glycylcycline, penam, tetracycline antibiotic, rifamycin antibiotic, phenicol antibiotic, disinfecting agents and antisepticsantibiotic effluxCARD (3.3.0)
J, K, L
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpfluoroquinolone antibiotic, cephalosporin, glycylcycline, penam, tetracycline antibiotic, rifamycin antibiotic, phenicol antibiotic, disinfecting agents and antisepticsantibiotic effluxCARD (3.3.0)
J, K, L
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpfluoroquinolone antibiotic, cephalosporin, glycylcycline, penam, tetracycline antibiotic, rifamycin antibiotic, phenicol antibiotic, disinfecting agents and antisepticsantibiotic effluxCARD (3.3.0)
A, B, C
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpmacrolide antibiotic, fluoroquinolone antibiotic, aminoglycoside antibiotic, carbapenem, cephalosporin, glycylcycline, cephamycin, penam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, rifamycin antibiotic, phenicol antibiotic, penem, disinfecting agents and antisepticsantibiotic effluxCARD (3.3.0)
A, B, C
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpmacrolide antibiotic, fluoroquinolone antibiotic, aminoglycoside antibiotic, carbapenem, cephalosporin, glycylcycline, cephamycin, penam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, rifamycin antibiotic, phenicol antibiotic, penem, disinfecting agents and antisepticsantibiotic effluxCARD (3.3.0)
A, B, C
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpmacrolide antibiotic, fluoroquinolone antibiotic, aminoglycoside antibiotic, carbapenem, cephalosporin, glycylcycline, cephamycin, penam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, rifamycin antibiotic, phenicol antibiotic, penem, disinfecting agents and antisepticsantibiotic effluxCARD (3.3.0)
D, E, F, G, H
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpfluoroquinolone antibiotic, cephalosporin, glycylcycline, penam, tetracycline antibiotic, rifamycin antibiotic, phenicol antibiotic, disinfecting agents and antisepticsantibiotic effluxCARD (3.3.0)
D, E, F, G, H
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpfluoroquinolone antibiotic, cephalosporin, glycylcycline, penam, tetracycline antibiotic, rifamycin antibiotic, phenicol antibiotic, disinfecting agents and antisepticsantibiotic effluxCARD (3.3.0)
D, E, F, G, H
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpfluoroquinolone antibiotic, cephalosporin, glycylcycline, penam, tetracycline antibiotic, rifamycin antibiotic, phenicol antibiotic, disinfecting agents and antisepticsantibiotic effluxCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
J, K, L
PF00873AcrB/AcrD/AcrF family (ACR_tran)AcrB/AcrD/AcrF family- Family
A, B, C
PF02321Outer membrane efflux protein (OEP)Outer membrane efflux protein- Family
D, E, F, G, H
PF16576Barrel-sandwich domain of CusB or HlyD membrane-fusion (HlyD_D23)Barrel-sandwich domain of CusB or HlyD membrane-fusionHlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole ...HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.
Domain
M, N, O
PF10766Multidrug efflux pump-associated protein AcrZ (AcrZ)Multidrug efflux pump-associated protein AcrZ- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
J, K, L
Multidrug efflux pump subunit AcrB
A, B, C
Outer membrane protein TolC
D, E, F, G, H
Multidrug efflux pump subunit AcrA
M, N, O
Multidrug efflux pump accessory protein AcrZ

Membrane Protein Annotation: OPM OPM Database Homepage

ChainsExternal LinkTypeClassSuperfamilyFamily
A, B, C, D, E
OPMTransmembraneAlpha-helical polytopicResistance-nodulation-cell divisionHydrophobe/amphiphile efflux-1 family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

ChainsExternal LinkComment
A, B, C, D, E
PDBTMAnnotated as membrane protein by PDBTM