5OKN | pdb_00005okn

Crystal structure of human SHIP2 Phosphatase-C2 D607A mutant

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e5oknA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: UNK_F_TYPE	ECOD (1.6)
A	Exo_endo_phos	e5oknA1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)
B	ANAPC8	e5oknB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: ANAPC8	ECOD (1.6)
B	Exo_endo_phos	e5oknB1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)
C	UNK_F_TYPE	e5oknC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: UNK_F_TYPE	ECOD (1.6)
C	Exo_endo_phos	e5oknC1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)
D	ANAPC8	e5oknD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: ANAPC8	ECOD (1.6)
D	Exo_endo_phos	e5oknD2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)
E	ANAPC8	e5oknE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: ANAPC8	ECOD (1.6)
E	Exo_endo_phos	e5oknE2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)
F	ANAPC8	e5oknF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: ANAPC8	ECOD (1.6)
F	Exo_endo_phos	e5oknF2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)
G	ANAPC8	e5oknG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: ANAPC8	ECOD (1.6)
G	Exo_endo_phos	e5oknG2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)
H	ANAPC8	e5oknH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: ANAPC8	ECOD (1.6)
H	Exo_endo_phos	e5oknH2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (utative)
B	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (utative)
C	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (utative)
D	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (utative)
E	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (utative)
F	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (utative)
G	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (utative)
H	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF24147	SHIP1/2 second C2 domain (C2_SHIP1-2_2nd)	SHIP1/2 second C2 domain	This entry represents the second C2 domain of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatases 1/2 [1]. The C2 domains of these proteins modulate the activity of the phosphatase domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	inositol trisphosphate phosphatase activity phosphoric ester hydrolase activity inositol-polyphosphate 5-phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity protein binding binding SH2 domain binding protein domain specific binding SH3 domain binding phosphatidylinositol trisphosphate phosphatase activity inositol trisphosphate phosphatase activity phosphoric ester hydrolase activity inositol-polyphosphate 5-phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity protein binding binding SH2 domain binding protein domain specific binding SH3 domain binding phosphatidylinositol trisphosphate phosphatase activity phosphatidylinositol phosphate 5-phosphatase activity phosphatidylinositol phosphate phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity cytoskeletal protein binding actin binding	phosphatidylinositol metabolic process dephosphorylation glycerophospholipid metabolic process lipid modification primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphatidylinositol dephosphorylation phospholipid dephosphorylation phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process phosphorus metabolic process phosphatidylinositol metabolic process dephosphorylation glycerophospholipid metabolic process lipid modification primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphatidylinositol dephosphorylation phospholipid dephosphorylation phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication intracellular signaling cassette signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction localization import into cell transport endocytosis establishment of localization vesicle-mediated transport MAPK cascade ERK1 and ERK2 cascade apoptotic process cell death programmed cell death developmental process endochondral ossification multicellular organismal process replacement ossification animal organ development endochondral bone morphogenesis multicellular organism development anatomical structure morphogenesis skeletal system development ossification anatomical structure development skeletal system morphogenesis animal organ morphogenesis bone morphogenesis bone development system development regulation of response to stimulus immune response immune system process regulation of immune response regulation of immune system process regulation of cytoskeleton organization regulation of actin filament organization regulation of cellular component organization regulation of actin filament-based process actin cytoskeleton organization actin filament organization regulation of organelle organization cellular component organization organelle organization regulation of actin cytoskeleton organization actin filament-based process regulation of supramolecular fiber organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization glycerophospholipid biosynthetic process lipid biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate biosynthetic process monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process glucose metabolic process establishment of organelle localization cellular localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of cell polarity mitotic cell cycle process establishment of mitotic spindle orientation microtubule-based process macromolecule metabolic process gene expression macromolecule biosynthetic process plasma membrane bounded cell projection organization ruffle organization cell projection organization plasma membrane bounded cell projection assembly ruffle assembly cellular component biogenesis cellular component assembly cell projection assembly negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process regulation of localization regulation of protein localization macromolecule localization intracellular protein localization response to hormone response to chemical response to endogenous stimulus response to peptide hormone response to insulin response to oxygen-containing compound response to nitrogen compound cell adhesion negative regulation of signaling regulation of signal transduction negative regulation of cell communication cell surface receptor protein tyrosine kinase signaling pathway regulation of insulin-like growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus insulin-like growth factor receptor signaling pathway negative regulation of insulin-like growth factor receptor signaling pathway negative regulation of signal transduction regulation of cell communication regulation of biosynthetic process negative regulation of metabolic process regulation of macromolecule metabolic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process negative regulation of macromolecule metabolic process post-embryonic development	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck ribonucleoprotein granule nuclear body nucleoplasm organelle lumen supramolecular complex nuclear ribonucleoprotein granule nuclear lumen cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region cytoplasm cytosol Golgi apparatus endomembrane system actin-based cell projection filopodium

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR057509	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, second C2 domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000980	SH2 domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000300	Inositol polyphosphate-related phosphatase	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR057510	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, first C2 domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036691	Endonuclease/exonuclease/phosphatase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001660	Sterile alpha motif domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: O15357	opsismodysplasia metabolic syndrome X type 2 diabetes mellitus schneckenbecken dysplasia hypertensive disorder Liver Cirrhosis, Experimental acquired metabolic disease intellectual disability lung carcinoma ovarian cancer astrocytic tumor glioblastoma large cell medulloblastoma malignant ependymoma diabetes mellitus opsismodysplasia metabolic syndrome X type 2 diabetes mellitus schneckenbecken dysplasia hypertensive disorder Liver Cirrhosis, Experimental acquired metabolic disease intellectual disability lung carcinoma ovarian cancer astrocytic tumor glioblastoma large cell medulloblastoma malignant ependymoma diabetes mellitus medulloblastoma osteosarcoma subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.