5XFE

Luciferin-regenerating enzyme solved by SAD using XFEL (refined against 11,000 patterns)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5xfea_	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	automated matches	automated matches	Common eastern firefly (Photinus pyralis ) [TaxId: 7054 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8086690	3000504	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SGL	e5xfeA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: SGL	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08450	SMP-30/Gluconolactonase/LRE-like region (SGL)	SMP-30/Gluconolactonase/LRE-like region	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Luciferin regenerating enzyme	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity gluconolactonase activity catalytic activity	monosaccharide metabolic process oxoacid metabolic process vitamin biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process L-ascorbic acid metabolic process lactone biosynthetic process small molecule metabolic process water-soluble vitamin metabolic process carbohydrate metabolic process water-soluble vitamin biosynthetic process small molecule biosynthetic process carbohydrate biosynthetic process monosaccharide metabolic process oxoacid metabolic process vitamin biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process L-ascorbic acid metabolic process lactone biosynthetic process small molecule metabolic process water-soluble vitamin metabolic process carbohydrate metabolic process water-soluble vitamin biosynthetic process small molecule biosynthetic process carbohydrate biosynthetic process carboxylic acid metabolic process monosaccharide biosynthetic process primary metabolic process vitamin metabolic process biosynthetic process lactone metabolic process metabolic process cellular process L-ascorbic acid biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
A	IPR013658	SMP-30/Gluconolactonase/LRE-like region	Domain
A	IPR005511	Senescence marker protein-30 (SMP-30)	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.