5Y8H
Mycobacterium tuberculosis 3-Hydroxyisobutyrate dehydrogenase (MtHIBADH) + NAD+
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | NAD_binding_11 | e5y8hB1 | A: alpha arrays | X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | T: 6-phosphogluconate dehydrogenase C-terminal domain-like | F: NAD_binding_11 | ECOD (1.6) |
B | NAD_binding_2 | e5y8hB2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: NAD_binding_2 | ECOD (1.6) |
A | NAD_binding_11 | e5y8hA1 | A: alpha arrays | X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | T: 6-phosphogluconate dehydrogenase C-terminal domain-like | F: NAD_binding_11 | ECOD (1.6) |
A | NAD_binding_2 | e5y8hA2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: NAD_binding_2 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
B | 1.10.1040.10 | Mainly Alpha | Orthogonal Bundle | N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase | domain 2 | CATH (4.3.0) |
A | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
A | 1.10.1040.10 | Mainly Alpha | Orthogonal Bundle | N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase | domain 2 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF14833 | NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase (NAD_binding_11) | NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase | 3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidised to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. The reaction is NADP-dependent a ... | Domain | |
PF03446 | NAD binding domain of 6-phosphogluconate dehydrogenase (NAD_binding_2) | NAD binding domain of 6-phosphogluconate dehydrogenase | The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR006115 | 6-phosphogluconate dehydrogenase, NADP-binding | Domain | |
IPR029154 | 3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain | Domain | |
IPR008927 | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily | Homologous Superfamily | |
IPR011548 | 3-hydroxyisobutyrate dehydrogenase | Family | |
IPR015815 | 3-hydroxyisobutyrate dehydrogenase-related | Family | |
IPR036291 | NAD(P)-binding domain superfamily | Homologous Superfamily | |
IPR013328 | 6-phosphogluconate dehydrogenase, domain 2 | Homologous Superfamily | |
IPR002204 | 3-hydroxyisobutyrate dehydrogenase-related, conserved site | Conserved Site |