6C0L
Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d6c0lb_ | Multi-domain proteins (alpha and beta) | DNA/RNA polymerases | DNA/RNA polymerases | Reverse transcriptase | HIV-1 reverse transcriptase | isolate BH10 (Human immunodeficiency virus type 1 BH10 ) [TaxId: 11678 ], | SCOPe (2.08) |
A | d6c0la2 | Alpha and beta proteins (a/b) | Ribonuclease H-like motif | Ribonuclease H-like | automated matches | automated matches | isolate BH10 (Human immunodeficiency virus type 1 BH10 ) [TaxId: 11678 ], | SCOPe (2.08) |
A | d6c0la1 | Multi-domain proteins (alpha and beta) | DNA/RNA polymerases | DNA/RNA polymerases | Reverse transcriptase | HIV-1 reverse transcriptase | isolate BH10 (Human immunodeficiency virus type 1 BH10 ) [TaxId: 11678 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | RVT_thumb | e6c0lB2 | A: alpha bundles | X: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | H: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | T: helical bundle domain in reverse transcriptase-like polymerases | F: RVT_thumb | ECOD (1.6) |
B | RVT_1 | e6c0lB3 | A: a+b two layers | X: Alpha-beta plaits | H: Adenylyl and guanylyl cyclase catalytic domain-like | T: Adenylyl and guanylyl cyclase catalytic domain-like | F: RVT_1 | ECOD (1.6) |
B | RVT_connect | e6c0lB1 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: RNaseH-like domain in reverse transcriptase (From Topology) | T: RNaseH-like domain in reverse transcriptase | F: RVT_connect | ECOD (1.6) |
A | RVT_thumb | e6c0lA3 | A: alpha bundles | X: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | H: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | T: helical bundle domain in reverse transcriptase-like polymerases | F: RVT_thumb | ECOD (1.6) |
A | RVT_1 | e6c0lA2 | A: a+b two layers | X: Alpha-beta plaits | H: Adenylyl and guanylyl cyclase catalytic domain-like | T: Adenylyl and guanylyl cyclase catalytic domain-like | F: RVT_1 | ECOD (1.6) |
A | RNase_H | e6c0lA4 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: RNase_H | ECOD (1.6) |
A | RVT_connect | e6c0lA1 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: RNaseH-like domain in reverse transcriptase (From Topology) | T: RNaseH-like domain in reverse transcriptase | F: RVT_connect | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 3.10.10.10 | Alpha Beta | Roll | HIV Type 1 Reverse Transcriptase | Chain A, domain 1 | CATH (utative) |
B | 3.30.70.270 | Alpha Beta | 2-Layer Sandwich | Alpha-Beta Plaits | Reverse transcriptase/Diguanylate cyclase domain | CATH (utative) |
A | 3.10.10.10 | Alpha Beta | Roll | HIV Type 1 Reverse Transcriptase | Chain A, domain 1 | CATH (utative) |
A | 3.30.70.270 | Alpha Beta | 2-Layer Sandwich | Alpha-Beta Plaits | Reverse transcriptase/Diguanylate cyclase domain | CATH (utative) |
A | 3.30.420.10 | Alpha Beta | 2-Layer Sandwich | Nucleotidyltransferase | domain 5 | CATH (utative) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF06817 | Reverse transcriptase thumb domain (RVT_thumb) | Reverse transcriptase thumb domain | This domain is known as the thumb domain. It is composed of a four helix bundle [1]. | Domain | |
PF06815 | Reverse transcriptase connection domain (RVT_connect) | Reverse transcriptase connection domain | This domain is known as the connection domain. This domain lies between the thumb and palm domains [1]. | Domain | |
PF00078 | Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1) | Reverse transcriptase (RNA-dependent DNA polymerase) | A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ... | Domain | |
PF06817 | Reverse transcriptase thumb domain (RVT_thumb) | Reverse transcriptase thumb domain | This domain is known as the thumb domain. It is composed of a four helix bundle [1]. | Domain | |
PF06815 | Reverse transcriptase connection domain (RVT_connect) | Reverse transcriptase connection domain | This domain is known as the connection domain. This domain lies between the thumb and palm domains [1]. | Domain | |
PF00075 | RNase H (RNase_H) | RNase H | RNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers. | Domain | |
PF00078 | Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1) | Reverse transcriptase (RNA-dependent DNA polymerase) | A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ... | Domain |