Annotations: 6PSX

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	E1-E2_ATPase_N	e6psxA3	A: beta sandwiches	X: jelly-roll	H: Calcium ATPase, transduction domain A (From Topology)	T: Calcium ATPase, transduction domain A	F: E1-E2_ATPase_N	ECOD (1.6)
A	UNK_F_TYPE	e6psxA4	A: alpha bundles	X: Calcium ATPase transmembrane domain-related (From Homology)	H: Calcium ATPase transmembrane domain-related	T: Calcium ATPase transmembrane domain M	F: UNK_F_TYPE	ECOD (1.6)
A	Cation_ATPase	e6psxA2	A: a+b complex topology	X: Metal cation-transporting ATPase, ATP-binding domain (From Topology)	H: Metal cation-transporting ATPase, ATP-binding domain (From Topology)	T: Metal cation-transporting ATPase, ATP-binding domain	F: Cation_ATPase	ECOD (1.6)
A	Hydrolase_3_1	e6psxA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Hydrolase_3_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth E]	PF03381	LEM3 (ligand-effect modulator 3) family / CDC50 family (CDC50)	LEM3 (ligand-effect modulator 3) family / CDC50 family	-	Family
A	PF16212	Phospholipid-translocating P-type ATPase C-terminal (PhoLip_ATPase_C)	Phospholipid-translocating P-type ATPase C-terminal	-	Family
A	PF13246	P-type ATPase, cytoplasmic domain N (Cation_ATPase)	P-type ATPase, cytoplasmic domain N	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth E]	Cell division control protein 50	-	cellular localization establishment of protein localization nitrogen compound transport transport intracellular transport establishment of localization localization protein transport establishment of localization in cell macromolecule localization cellular process intracellular protein localization intracellular protein transport membrane organization cellular localization establishment of protein localization nitrogen compound transport transport intracellular transport establishment of localization localization protein transport establishment of localization in cell macromolecule localization cellular process intracellular protein localization intracellular protein transport membrane organization phospholipid translocation biological regulation lipid localization phospholipid transport lipid transport lipid translocation regulation of membrane lipid distribution cellular component organization aminophospholipid translocation aminophospholipid transport cellular component organization or biogenesis regulation of biological quality organophosphate ester transport actin cortical patch localization vesicle-mediated transport endosomal transport cytosolic transport retrograde transport, endosome to Golgi import into cell endocytosis	membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle trans-Golgi network cytoplasm cytosol phospholipid-translocating ATPase complex membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle trans-Golgi network cytoplasm cytosol phospholipid-translocating ATPase complex Cdc50p-Drs2p complex protein-containing complex transporter complex cell periphery plasma membrane membrane endosome membrane endosome intracellular vesicle late endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane late endosome vesicle organelle membrane endoplasmic reticulum
A	Probable phospholipid-transporting ATPase DRS2	ATPase-coupled intramembrane lipid transporter activity lipid transporter activity intramembrane lipid transporter activity transporter activity ATP-dependent activity glycerophospholipid flippase activity phosphatidylserine flippase activity aminophospholipid flippase activity flippase activity phospholipid transporter activity phosphatidylcholine transporter activity phosphatidylcholine flippase activity cation binding magnesium ion binding ATPase-coupled intramembrane lipid transporter activity lipid transporter activity intramembrane lipid transporter activity transporter activity ATP-dependent activity glycerophospholipid flippase activity phosphatidylserine flippase activity aminophospholipid flippase activity flippase activity phospholipid transporter activity phosphatidylcholine transporter activity phosphatidylcholine flippase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding phosphatidylethanolamine flippase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding phosphatidylserine floppase activity floppase activity phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol-4-phosphate binding phosphatidylinositol binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	localization post-Golgi vesicle-mediated transport transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport import into cell endocytosis cellular localization intracellular transport localization within membrane endocytic recycling endosomal transport localization post-Golgi vesicle-mediated transport transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport import into cell endocytosis cellular localization intracellular transport localization within membrane endocytic recycling endosomal transport vesicle-mediated transport to the plasma membrane establishment of localization in cell membrane organization phospholipid translocation biological regulation lipid localization phospholipid transport lipid transport lipid translocation regulation of membrane lipid distribution cellular component organization macromolecule localization cellular component organization or biogenesis regulation of biological quality organophosphate ester transport	phospholipid-translocating ATPase complex Cdc50p-Drs2p complex protein-containing complex transporter complex cell periphery cellular anatomical structure plasma membrane membrane membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle phospholipid-translocating ATPase complex Cdc50p-Drs2p complex protein-containing complex transporter complex cell periphery cellular anatomical structure plasma membrane membrane membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle trans-Golgi network cytoplasm endosome membrane endosome intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle vesicle organelle membrane endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth E]	IPR005045	CDC50/LEM3 family	Family
A	IPR001757	P-type ATPase	Family
A	IPR044492	P-type ATPase, haloacid dehalogenase domain	Domain
A	IPR006539	P-type ATPase, subfamily IV	Family
A	IPR018303	P-type ATPase, phosphorylation site	PTM
A	IPR023298	P-type ATPase, transmembrane domain superfamily	Homologous Superfamily
A	IPR032631	P-type ATPase, N-terminal	Domain
A	IPR023214	HAD superfamily	Homologous Superfamily
A	IPR008250	P-type ATPase, A domain superfamily	Homologous Superfamily
A	IPR036412	HAD-like superfamily	Homologous Superfamily
A	IPR032630	P-type ATPase, C-terminal	Domain
A	IPR023299	P-type ATPase, cytoplasmic domain N	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth E]	OPM	Transmembrane	Alpha-helical polytopic	P-type ATPase (P-ATPase)	Phospholipid-translocating ATPase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth E]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B [auth E]	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.