6QSX | pdb_00006qsx

Complement factor B protease domain in complex with the reversible inhibitor ((2S,4S)-1-((5,7-dimethyl-1H-indol-4-yl)methyl)-4-methoxypiperidin-2-yl)methanol.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth AAA]	SCOP2B Superfamily	Trypsin-like serine proteases	8042311	3000114	SCOP2B (2022-06-29)
B [auth BBB]	SCOP2B Superfamily	Trypsin-like serine proteases	8042311	3000114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth AAA]	Trypsin_1	e6qsxAAA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)
B [auth BBB]	Trypsin_1	e6qsxBBB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA], B [auth BBB]	PF00089	Trypsin (Trypsin)	Trypsin		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA], B [auth BBB]	Complement factor B	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding complement binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus humoral immune response positive regulation of biological process complement activation, alternative pathway positive regulation of response to stimulus complement activation positive regulation of immune response response to stress biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus humoral immune response positive regulation of biological process complement activation, alternative pathway positive regulation of response to stimulus complement activation positive regulation of immune response response to stress innate immune response regulation of immune system process positive regulation of immune system process regulation of biological process immune response defense response biological regulation defense response to symbiont immune effector process regulation of response to stimulus immune system process defense response to other organism regulation of immune response activation of immune response proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure extracellular region extracellular space blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA], B [auth BBB]	IPR011360	Complement B/C2	Family
A [auth AAA], B [auth BBB]	IPR028341	Complement factor B	Family
A [auth AAA], B [auth BBB]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR001314	Peptidase S1A, chymotrypsin family	Family
A [auth AAA], B [auth BBB]	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A [auth AAA], B [auth BBB]	IPR001254	Serine proteases, trypsin domain	Domain
A [auth AAA], B [auth BBB]	IPR002035	von Willebrand factor, type A	Domain
A [auth AAA], B [auth BBB]	IPR000436	Sushi/SCR/CCP domain	Domain
A [auth AAA], B [auth BBB]	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
A [auth AAA], B [auth BBB]	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AAA], B [auth BBB]	Pharos: P00751	age-related macular degeneration complement factor b deficiency atypical hemolytic-uremic syndrome myasthenia gravis atypical hemolytic-uremic syndrome with B factor anomaly systemic lupus erythematosus ulcerative colitis hemolytic-uremic syndrome Libman-Sacks Disease macular degeneration membranous glomerulonephritis ovarian cancer age related macular degeneration 14 retinal degeneration wet macular degeneration age-related macular degeneration complement factor b deficiency atypical hemolytic-uremic syndrome myasthenia gravis atypical hemolytic-uremic syndrome with B factor anomaly systemic lupus erythematosus ulcerative colitis hemolytic-uremic syndrome Libman-Sacks Disease macular degeneration membranous glomerulonephritis ovarian cancer age related macular degeneration 14 retinal degeneration wet macular degeneration cervical cancer Hashimoto thyroiditis hypertensive disorder lung carcinoma neuromyelitis optica psoriasis skin basal cell carcinoma autism spectrum disorder brain injury heart disease non-alcoholic fatty liver disease psoriatic arthritis squamous cell lung carcinoma vitiligo endometriosis hemolytic anemia hepatitis B virus infection

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.